Reference Intervals of Serum Non-Cholesterol Sterols by Gender in Healthy Japanese Individuals

• Published in: Journal of Atherosclerosis and Thrombosis Vol. 27; no. 5; pp. 409 - 417
• Main Authors: Yoshida, Hiroshi, Tada, Hayato, Ito, Kumie, Kishimoto, Yoshimi, Yanai, Hidekatsu, Okamura, Tomonori, Ikewaki, Katsunori, Inagaki, Kyoko, Shoji, Tetsuo, Bujo, Hideaki, Miida, Takashi, Yoshida, Masayuki, Kuzuya, Masafumi, Yamashita, Shizuya
• Format: Journal Article
• Language: English
• Published: Japan Japan Atherosclerosis Society 01.05.2020
• Subjects: ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics; ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics; Cholesterol - analogs & derivatives; Cholesterol - blood; Cholesterol, Dietary - metabolism; Chromatography, Gas - methods; Chromatography, Gas - standards; Female; Gas chromatography; Humans; Hypercholesterolemia - diagnosis; Hypercholesterolemia - epidemiology; Hypercholesterolemia - genetics; Hypercholesterolemia - therapy; Intestinal Diseases - diagnosis; Intestinal Diseases - epidemiology; Intestinal Diseases - genetics; Intestinal Diseases - therapy; Japan - epidemiology; Lipid Metabolism, Inborn Errors - diagnosis; Lipid Metabolism, Inborn Errors - epidemiology; Lipid Metabolism, Inborn Errors - genetics; Lipid Metabolism, Inborn Errors - therapy; Lipoproteins - genetics; Male; Middle Aged; Non-cholesterol sterol; Original; Phytosterols - adverse effects; Phytosterols - blood; Phytosterols - genetics; Reference interval; Reference Values; Reproducibility of Results; Sex Factors; Sitosterolemia; Sitosterols - blood; Japan; Gas chromatography; Non-cholesterol sterol; Reference interval; Sitosterolemia

Aims: The present study was conducted to establish a practical method for measuring non-cholesterol sterols and reference intervals of serum levels.Methods: Healthy subjects (109 men and 151 women), four patients with sitosterolemia, and 10 heterozygous mutation carriers of ABCG5/ABCG8 genes were in...