Effects of a Vegetarian Diet on Cardiometabolic Risk Factors, Gut Microbiota, and Plasma Metabolome in Subjects With Ischemic Heart Disease: A Randomized, Crossover Study

• Published in: Journal of the American Heart Association Vol. 9; no. 18; p. e016518
• Main Authors: Djekic, Demir, Shi, Lin, Brolin, Harald, Carlsson, Frida, Särnqvist, Charlotte, Savolainen, Otto, Cao, Yang, Bäckhed, Fredrik, Tremaroli, Valentina, Landberg, Rikard, Frøbert, Ole
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 15.09.2020; Wiley
• Subjects: acid-metabolism; Aged; barriers; benefits; Cardiology and Cardiovascular Disease; Cardiometabolic Risk Factors; Cardiovascular System & Cardiology; Cholesterol, LDL - blood; consumption; controlled trial; Coronary artery disease; Cross-Over Studies; Diet, Vegetarian; Fatty Acids - metabolism; Female; Gastrointestinal Microbiome; gut microbiota; Humans; intestinal microbiota; Kardiologi och kardiovaskulära sjukdomar; ldl; Male; Metabolome; Middle Aged; mortality; Myocardial Ischemia - blood; Myocardial Ischemia - diet therapy; Original Research; oxidized; plasma metabolome; randomized; randomized controlled trial; term changes; trimethylamine N-oxide; vegetarian diet; weight; coronary artery disease; vegetarian diet; plasma metabolome; trimethylamine N-oxide; gut microbiota; randomized controlled trial
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.120.016518

Background A vegetarian diet (VD) may reduce future cardiovascular risk in patients with ischemic heart disease. Methods and Results A randomized crossover study was conducted in subjects with ischemic heart disease, assigned to 4-week intervention periods of isocaloric VD and meat diet (MD) with in...