Intrathecal Disposition of ARTCEREB® Irrigation and Perfusion Solution for Cerebrospinal Surgery in Rats
We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35 ml/kg/h, taking into consideration the clinical perfu...
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| Published in | Biological & Pharmaceutical Bulletin Vol. 34; no. 5; pp. 688 - 692 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Japanese |
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Japan
The Pharmaceutical Society of Japan
2011
Pharmaceutical Society of Japan Japan Science and Technology Agency |
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| Abstract | We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35 ml/kg/h, taking into consideration the clinical perfusion rate (500 ml/60 kg/d). The influence of Artcereb on electrolytes in cerebrospinal fluid (CSF) and blood were then investigated. After 24 h of ventriculocisternal perfusion with Artcereb using the push-pull method, output of K+, Na+ and Cl− to the cistern magna was very similar to input of these electrolytes in Artcereb infused intraventricularly. Recovery rates of K+, Na+ and Cl− after perfusion were 102%, 105% and 100% when calculated using the recovered perfusion solution. In addition, concentrations of K+, Na+ and Cl− in blood remained almost constant at near baseline levels throughout perfusion. Thus, intrathecally perfused Artcereb did not affect electrolyte balance in the CSF and blood. To confirm the dynamics of Artcereb distribution, a whole body autoradiography study was performed at 1 and 6 h after perfusion with 14C-inulin-added Artcereb. Radioactivity was detected in the entire CSF space of the brain, and the cribriform plate in the nasal cavity, and the cerebrospinal cavity. Radioactivity was observed in the bladder, thus suggesting that some 14C-inulin was transferred to the bloodstream via a physiological route, and was excreted renally. |
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| AbstractList | We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35 ml/kg/h, taking into consideration the clinical perfusion rate (500 ml/60 kg/d). The influence of Artcereb on electrolytes in cerebrospinal fluid (CSF) and blood were then investigated. After 24 h of ventriculocisternal perfusion with Artcereb using the push-pull method, output of K(+), Na(+) and Cl(-) to the cistern magna was very similar to input of these electrolytes in Artcereb infused intraventricularly. Recovery rates of K(+), Na(+) and Cl(-) after perfusion were 102%, 105% and 100% when calculated using the recovered perfusion solution. In addition, concentrations of K(+), Na(+) and Cl(-) in blood remained almost constant at near baseline levels throughout perfusion. Thus, intrathecally perfused Artcereb did not affect electrolyte balance in the CSF and blood. To confirm the dynamics of Artcereb distribution, a whole body autoradiography study was performed at 1 and 6 h after perfusion with ¹⁴C-inulin-added Artcereb. Radioactivity was detected in the entire CSF space of the brain, and the cribriform plate in the nasal cavity, and the cerebrospinal cavity. Radioactivity was observed in the bladder, thus suggesting that some ¹⁴C-inulin was transferred to the bloodstream via a physiological route, and was excreted renally. We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35 ml/kg/h, taking into consideration the clinical perfusion rate (500 ml/60 kg/d). The influence of Artcereb on electrolytes in cerebrospinal fluid (CSF) and blood were then investigated. After 24 h of ventriculocisternal perfusion with Artcereb using the push-pull method, output of K+, Na+ and Cl- to the cistern magna was very similar to input of these electrolytes in Artcereb infused intraventricularly. Recovery rates of K+, Na+ and Cl- after perfusion were 102%, 105% and 100% when calculated using the recovered perfusion solution. In addition, concentrations of K+, Na+ and Cl- in blood remained almost constant at near baseline levels throughout perfusion. Thus, intrathecally perfused Artcereb did not affect electrolyte balance in the CSF and blood. To confirm the dynamics of Artcereb distribution, a whole body autoradiography study was performed at 1 and 6 h after perfusion with 14C-inulin-added Artcereb. Radioactivity was detected in the entire CSF space of the brain, and the cribriform plate in the nasal cavity, and the cerebrospinal cavity. Radioactivity was observed in the bladder, thus suggesting that some 14C-inulin was transferred to the bloodstream via a physiological route, and was excreted renally. We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35 ml/kg/h, taking into consideration the clinical perfusion rate (500 ml/60 kg/d). The influence of Artcereb on electrolytes in cerebrospinal fluid (CSF) and blood were then investigated. After 24 h of ventriculocisternal perfusion with Artcereb using the push-pull method, output of K+, Na+ and Cl− to the cistern magna was very similar to input of these electrolytes in Artcereb infused intraventricularly. Recovery rates of K+, Na+ and Cl− after perfusion were 102%, 105% and 100% when calculated using the recovered perfusion solution. In addition, concentrations of K+, Na+ and Cl− in blood remained almost constant at near baseline levels throughout perfusion. Thus, intrathecally perfused Artcereb did not affect electrolyte balance in the CSF and blood. To confirm the dynamics of Artcereb distribution, a whole body autoradiography study was performed at 1 and 6 h after perfusion with 14C-inulin-added Artcereb. Radioactivity was detected in the entire CSF space of the brain, and the cribriform plate in the nasal cavity, and the cerebrospinal cavity. Radioactivity was observed in the bladder, thus suggesting that some 14C-inulin was transferred to the bloodstream via a physiological route, and was excreted renally. We investigated the disposition of ARTCEREB(R) irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal perfusion model in conscious rats. In this perfusion model, the perfusion rate was set at 0.35ml/kg/h, taking into consideration the clinical perfusion rate (500 ml/60kg/d). The influence of Artcereb on electrolytes in cerebrospinal fluid (CSF) and blood were then investigated. After 24 h of ventriculocisternal perfusion with Artcereb using the push-pull method, output of K+, Na+ and Cl- to the cistern magna was very similar to input of these electrolytes in Artcereb infused intraventricularly. Recovery rates of K+, Na+ and Cl- after perfusion were 102%, 105% and 100% when calculated using the recovered perfusion solution. In addition, concentrations of K+, Na+ and Cl- in blood remained almost constant at near baseline levels throughout perfusion. Thus, intrathecally perfused Artcereb did not affect electrolyte balance in the CSF and blood. To confirm the dynamics of Artcereb distribution, a whole body autoradiography study was performed at 1 and 6 h after perfusion with 14C-inulin-added Artcereb. Radioactivity was detected in the entire CSF space of the brain, and the cribriform plate in the nasal cavity, and the cerebrospinal cavity. Radioactivity was observed in the bladder, thus suggesting that some 14C-inulin was transferred to the bloodstream via a physiological route, and was excreted renally. |
| Author | Takehara, Hiroaki Yamauchi, Aiko Morioka, Yujiro Doi, Kazuhisa Naito, Shinsaku Nishimura, Masuhiro |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21532158$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_wneu_2024_01_119 crossref_primary_10_1080_01616412_2019_1672383 crossref_primary_10_3390_biomedicines11051461 crossref_primary_10_1016_j_wneu_2020_07_017 crossref_primary_10_3389_fneur_2024_1376216 crossref_primary_10_1111_ases_12162 |
| Cites_doi | 10.1016/S0197-0186(03)00175-X 10.3109/02688699008992706 10.2131/jts.35.447 10.1227/00006123-199604000-00019 10.1248/yakushi.130.127 10.1007/BF01978633 10.1111/j.1748-1716.1963.tb02652.x 10.1016/S0304-3940(01)02526-5 10.1152/ajplegacy.1970.219.5.1528 10.1007/978-3-7091-6995-7_1 10.1248/yakushi.129.1121 10.2131/jts.34.511 10.1016/j.brainres.2008.10.044 10.1161/01.HYP.10.6.635 10.1016/j.surneu.2006.06.058 |
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| Snippet | We investigated the disposition of ARTCEREB® irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal... We investigated the disposition of ARTCEREB(R) irrigation and perfusion solution (Artcereb) during intrathecal perfusion in a lateral ventricle-cisternal... |
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| SubjectTerms | Animals ARTCEREB artificial cerebrospinal fluid Central Nervous System - surgery intrathecal perfusion Male Perfusion rat Rats Rats, Sprague-Dawley Spine - surgery Therapeutic Irrigation |
| Title | Intrathecal Disposition of ARTCEREB® Irrigation and Perfusion Solution for Cerebrospinal Surgery in Rats |
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