TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α and RANKL expression - Tenshin, Hirofumi; Teramachi, Jumpei; Ashtar, Mohannad; Hiasa, Masahiro; Inoue, Yusuke; Oda, Asuka; Tanimoto, Kotaro; Shimizu, So; Higa, Yoshiki; Harada, Takeshi; Oura, Masahiro; Sogabe, Kimiko; et al. (Clinical & translational immunology, 2022)
Keywords: Animal models; Antibodies; Bone marrow; Collagen; Cytokines; Enzyme inhibitors; Fibroblasts; Hypertrophy; Inflammasomes; Inflammation; Joint diseases; Kinases; Lipopolysaccharides; LL‐Z1640‐2; macrophage; Macrophages; NLRP3 inflammasome; Original; osteoclast; Osteoclasts; Phosphorylation; Proteinase; Proteins; Rheumatoid arthritis; synovial fibroblasts; TAK1; TAK1 protein; TRANCE protein; Tumor necrosis factor; TAK1; macrophage; synovial fibroblasts; NLRP3 inflammasome; osteoclast; LL‐Z1640‐2; rheumatoid arthritis