Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls

• Published in: Journal of psychiatric research Vol. 44; no. 15; pp. 1075 - 1081
• Main Authors: Mercedes Perez-Rodriguez, M., Weinstein, Shauna, New, Antonia S., Bevilacqua, Laura, Yuan, Qiaoping, Zhou, Zhifeng, Hodgkinson, Colin, Goodman, Marianne, Koenigsberg, Harold W., Goldman, David, Siever, Larry J.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.11.2010; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Affective instability; Aggression; Aggression - psychology; Biological and medical sciences; Borderline personality disorder; Borderline Personality Disorder - ethnology; Borderline Personality Disorder - genetics; Borderline Personality Disorder - psychology; Ethnicity - genetics; Female; Gene Frequency; Genes; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study - methods; Haplotypes; Humans; Impulsive aggression; Impulsivity; Indexing in process; Male; Medical sciences; Middle Aged; Personality disorders; Polymorphism, Single Nucleotide - genetics; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Sex Factors; Suicidal behavior; Suicidal behaviour; Suicide; Suicide, Attempted - psychology; Surveys and Questionnaires; TPH2; Tryptophan Hydroxylase - genetics; White People - ethnology; Affective instability; TPH2; Suicidal behavior; Impulsive aggression; Borderline personality disorder; Human; Impulsivity; Borderline; Enzyme; Aggression; Emotional disorder; Suicide; Genetic determinism; Personality disorder; Suicide attempt; Tryptophan 5-monooxygenase; Genetics; Oxidoreductases; Haplotype

There is a decreased serotonergic function in impulsive aggression and borderline personality disorder (BPD), and genetic association studies suggest a role of serotonergic genes in impulsive aggression and BPD. Only one study has analyzed the association between the tryptophan-hydroxylase 2 (TPH2)...