The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 - Skjesol, Astrid; Yurchenko, Mariia; Bösl, Korbinian; Gravastrand, Caroline; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Kumar Sharma, Aditya; et al. (PLoS pathogens, 2019)
Keywords: Actin; Activation; Adapters; Adaptor Proteins, Signal Transducing - metabolism; Adaptor Proteins, Signal Transducing - physiology; Animals; Bacteria; Biology and Life Sciences; Cancer; Carrier Proteins - metabolism; Carrier Proteins - physiology; cdc42 GTP-Binding Protein; Cdc42 protein; Cellular signal transduction; Cytological research; E coli; Endocytosis; Endosomes; Escherichia coli; Escherichia coli - pathogenicity; Funding; G proteins; Gram-negative bacteria; HEK293 Cells; Hospitals; Humans; Immune system; Immunology; Inflammation; Interferon Regulatory Factor-3; Light rail transit; Lipopolysaccharides; Macrophages; Macrophages - immunology; Macrophages - metabolism; Medical research; Medicine; Medicine and Health Sciences; Membrane Proteins - metabolism; Membrane Proteins - physiology; Mice; Mice, Inbred C57BL; Microorganisms; Monocytes; Myeloid Differentiation Factor 88; Phagocytes; Phagocytosis; Phagocytosis - physiology; Physiological aspects; Primary Cell Culture; Protein Transport; Protein-protein interactions; Proteins; rab GTP-Binding Proteins; rac1 GTP-Binding Protein; Rac1 protein; Research and Analysis Methods; Signal Transduction; Software; Staphylococcus aureus; Staphylococcus aureus - pathogenicity; Staphylococcus aureus infections; THP-1 Cells; TLR4; TLR4 protein; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Norway; Italy