Exercise Increases Age-Related Penetrance and Arrhythmic Risk in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy–Associated Desmosomal Mutation Carriers

• Published in: Journal of the American College of Cardiology Vol. 62; no. 14; pp. 1290 - 1297
• Main Authors: James, Cynthia A., Bhonsale, Aditya, Tichnell, Crystal, Murray, Brittney, Russell, Stuart D., Tandri, Harikrishna, Tedford, Ryan J., Judge, Daniel P., Calkins, Hugh
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - genetics; Arrhythmias, Cardiac - physiopathology; arrhythmogenic right ventricular dysplasia; Arrhythmogenic Right Ventricular Dysplasia - complications; Arrhythmogenic Right Ventricular Dysplasia - genetics; Arrhythmogenic Right Ventricular Dysplasia - physiopathology; Biological and medical sciences; Cardiac arrhythmia; Cardiac dysrhythmias; Cardiology; Cardiology. Vascular system; cardiomyopathy; Cardiovascular; Defibrillators; Desmosomes - genetics; Electrocardiography; exercise; Exercise - physiology; Female; Follow-Up Studies; General aspects. Genetic counseling; Heart; Heart attacks; heart failure; Humans; Male; Medical genetics; Medical sciences; Mutation; Penetrance; Prospective Studies; Risk Factors; ventricular arrhythmias; heart failure; OR; VT/VF; RV; ARVD/C; CI; penetrance; ECG; exercise; ICD; IQR; TFC; ventricular arrhythmias; arrhythmogenic right ventricular dysplasia; cardiomyopathy; HF; 2010 Revised Task Force Criteria; (stage C) heart failure; interquartile range; odds ratio; ventricular tachycardia/ventricular fibrillation; electrocardiogram; implantable cardioverter-defibrillator; right ventricular; arrhythmogenic right ventricular dysplasia/cardiomyopathy; confidence interval; Physical exercise; Arrhythmia; Cardiovascular disease; Risk; Increase; Genetic disease; Genetic counseling; Arrhythmogenic right ventricular dysplasia; Heart disease; Gene penetrance; Risk factor; Exercise tolerance test; Circulatory system; Mutation; Carrier; Cardiology; Age

This study sought to determine how exercise influences penetrance of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) among patients with desmosomal mutations. Although animal models and anecdotal evidence suggest that exercise is a risk factor for ARVD/C, there have been no system...