Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers

Background Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before havi...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 18; no. 10; p. e0292118
Main Authors Sasano, Tetsuo, Ihara, Kensuke, Tanaka, Toshihiro, Furukawa, Tetsushi
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 12.10.2023
Public Library of Science (PLoS)
Subjects
Analysis
Arrhythmia
Atrial fibrillation
Biological markers
Biology and Life Sciences
Biomarkers
Cardiac arrhythmia
Chromosomes
Congenital diseases
Diagnosis
Disease
Electrocardiography
Ethylenediaminetetraacetic acid
Evaluation
Fibrillation
Genetic analysis
Genetic aspects
Genetic diversity
Genotyping
Health risk assessment
Health risks
Heart failure
Medicine and Health Sciences
MicroRNA
MicroRNAs
miRNA
Nucleotides
Peripheral blood
Plasma
Polymorphism
Risk factors
Scientific equipment and supplies industry
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical significance
Stroke
Stroke (Disease)
Thoracic surgery
Japan
United States
Taiwan
United States > US
Online AccessGet full text

Cover

Abstract Background Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers. Materials and methods A total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR. Results Genotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke. Conclusion The risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.
AbstractList BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers.Materials and methodsA total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR.ResultsGenotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke.ConclusionThe risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.
Background Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers. Materials and methods A total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR. Results Genotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke. Conclusion The risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.
Background Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers. Materials and methods A total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR. Results Genotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke. Conclusion The risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.
Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers.BACKGROUNDAtrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers.A total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR.MATERIALS AND METHODSA total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR.Genotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke.RESULTSGenotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke.The risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.CONCLUSIONThe risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.
Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers. A total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR-342-5p) were quantified in serum using quantitative RT-PCR. Genotyping identified 4 single nucleotide polymorphisms (SNPs) that were significantly associated with AF (rs6817105, rs3807989, rs10824026, and rs2106261), and the genetic risk score using 4 SNPs showed the area under the curve (AUC) of 0.631. Circulating miRNAs and cfDNA did not show significant differences between PAF and control groups. The concentration of cfDNA was significantly higher in patients with a history of stroke, and the AUC was 0.950 to estimate the association with stroke. The risk of AF could be assessed by genetic risk score. Furthermore, the risk of stroke might be evaluated by plasma cfDNA level.
Audience Academic
Author Tanaka, Toshihiro
Ihara, Kensuke
Sasano, Tetsuo
Furukawa, Tetsushi
AuthorAffiliation 3 Bioresourse Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Keio University - Shinanomachi Campus: Keio Gijuku Daigaku - Shinanomachi Campus, JAPAN
4 Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
2 Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
1 Department of Cardiovascular Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
AuthorAffiliation_xml – name: 1 Department of Cardiovascular Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
– name: Keio University - Shinanomachi Campus: Keio Gijuku Daigaku - Shinanomachi Campus, JAPAN
– name: 3 Bioresourse Research Center, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
– name: 4 Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
– name: 2 Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Author_xml – sequence: 1
  givenname: Tetsuo
  orcidid: 0000-0003-3582-6104
  surname: Sasano
  fullname: Sasano, Tetsuo
– sequence: 2
  givenname: Kensuke
  surname: Ihara
  fullname: Ihara, Kensuke
– sequence: 3
  givenname: Toshihiro
  orcidid: 0000-0001-6201-9784
  surname: Tanaka
  fullname: Tanaka, Toshihiro
– sequence: 4
  givenname: Tetsushi
  surname: Furukawa
  fullname: Furukawa, Tetsushi
BookMark eNqNk9tq3DAQhk1Jocm2b1CooVDSi93qZMm-KiH0sBAIpIdbIcnSrnZlaSvZpXn7yrtuiUsuikAy42_-0YxmLoozH7wuipcQrCBm8N0uDNELtzpk8wqgBkFYPynOYYPRkiKAzx58PysuUtoBUOGa0vNiuLNpX6Y-it4aq_IefBlMKfpohSuNldE6dzIL345k2OtySNZvynFzuvSDcjr0ttXlIbj7LsTD1qbuyCsb1TD6Z1za0Im41zE9L54a4ZJ-MZ2L4tvHD1-vPy9vbj-tr69ulorWVb-UUiNEYGUwwNBQWIOKSigIEYZSSYGBkmGDtYGsMswoLIHAhGKWeSZrgBfFq5PuwYXEpzIljmpGCSGgQZlYn4g2iB0_RJtveM-DsPxoCHHDRextTpDnOBpVsEKMCWKokUwRDQFApAFSCpq13k_RBtnpVmmfy-pmovM_3m75JvzkMOfVVPlJFsXlpBDDj0Gnnnc2KZ0fwOswHC_OcA0gbjL6-h_08fQmaiNyBtabkAOrUZRfMZo7oAF4DLt6hMqr1Z1VuamMzfaZw9uZQ2Z6_avfiCElvv5y9__s7fc5--YBu9XC9dsU3DC2X5qD5ASqGFKK2vytMgR8nIk_1eDjTPBpJvBv3X8CUg
Cites_doi 10.1253/circj.CJ-17-1194
10.1161/CIRCULATIONAHA.121.055176
10.1016/j.tcm.2021.12.001
10.1373/49.10.1733
10.1097/FJC.0000000000001066
10.1073/pnas.0912585107
10.1038/s41598-021-85204-7
10.1371/journal.pone.0101318
10.1038/ng.416
10.1016/j.hrthm.2020.01.006
10.21037/apm-21-3518
10.1161/CIRCRESAHA.107.161182
10.1056/NEJM199809033391003
10.1016/j.cjca.2016.10.029
10.1371/journal.pone.0160577
10.2196/23440
10.1016/S0140-6736(19)31721-0
10.1161/CIRCULATIONAHA.112.001207
10.1016/j.ydbio.2008.12.028
10.1016/j.yjmcc.2007.01.008
10.1097/MD.0000000000028980
10.1038/ng.3843
10.3389/fcvm.2021.650667
10.1152/ajpheart.2000.278.4.H1153
10.1038/ng.2261
10.1056/NEJMoa2019422
10.1161/STROKEAHA.108.528752
10.1016/j.hrthm.2014.09.050
10.1001/jama.285.22.2864
10.1161/CIRCEP.115.003396
10.1038/s41588-018-0133-9
ContentType Journal Article
Copyright COPYRIGHT 2023 Public Library of Science
2023 Sasano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright: © 2023 Sasano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
2023 Sasano et al 2023 Sasano et al
2023 Sasano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: COPYRIGHT 2023 Public Library of Science
– notice: 2023 Sasano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright: © 2023 Sasano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
– notice: 2023 Sasano et al 2023 Sasano et al
– notice: 2023 Sasano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID AAYXX
CITATION
IOV
ISR
3V.
7QG
7QL
7QO
7RV
7SN
7SS
7T5
7TG
7TM
7U9
7X2
7X7
7XB
88E
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M7N
M7P
M7S
NAPCQ
P5Z
P62
P64
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PTHSS
PYCSY
RC3
7X8
5PM
DOA
DOI 10.1371/journal.pone.0292118
DatabaseName CrossRef
Gale in Context: Opposing Viewpoints
Gale in Context: Science
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Nursing & Allied Health Database (ProQuest)
Ecology Abstracts
Entomology Abstracts (Full archive)
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database (Proquest)
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agricultural Science Database
Health & Medical Collection (Alumni)
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
ProQuest Engineering Database
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
Engineering Collection
Environmental Science Collection
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Agricultural Science Database
Publicly Available Content Database
ProQuest Central Student
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList


MEDLINE - Academic

Agricultural Science Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
DocumentTitleAlternate Risk stratification of atrial fibrillation and stroke
EISSN 1932-6203
ExternalDocumentID 2876444092
oai_doaj_org_article_3efe2515277a4f6fb7c4e1002490bba6
PMC10569505
A768669035
10_1371_journal_pone_0292118
GeographicLocations Japan
United States
Taiwan
United States--US
GeographicLocations_xml – name: Japan
– name: Taiwan
– name: United States
– name: United States--US
GrantInformation_xml – fundername: ;
GroupedDBID ---
123
29O
2WC
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFKRA
AFPKN
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
EMOBN
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IGS
IHR
IHW
INH
INR
IOV
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
O5R
O5S
OK1
OVT
P2P
P62
PATMY
PDBOC
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
BBORY
PMFND
3V.
7QG
7QL
7QO
7SN
7SS
7T5
7TG
7TM
7U9
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
KL.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
RC3
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c685t-bbe22415f3031f618056b1a44af66b60f1b73f3ef175f7fc3b0a346373037b803
IEDL.DBID M48
ISSN 1932-6203
IngestDate Wed Aug 13 01:17:31 EDT 2025
Wed Aug 27 01:27:40 EDT 2025
Thu Aug 21 18:35:40 EDT 2025
Fri Jul 11 04:45:47 EDT 2025
Fri Jul 25 11:23:58 EDT 2025
Tue Jun 17 22:18:03 EDT 2025
Tue Jun 10 21:25:15 EDT 2025
Fri Jun 27 05:53:54 EDT 2025
Fri Jun 27 05:49:52 EDT 2025
Thu May 22 21:18:12 EDT 2025
Tue Jul 01 01:01:56 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 10
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Creative Commons Attribution License
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c685t-bbe22415f3031f618056b1a44af66b60f1b73f3ef175f7fc3b0a346373037b803
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: NO authors have competing interests.
ORCID 0000-0001-6201-9784
0000-0003-3582-6104
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0292118
PQID 2876444092
PQPubID 1436336
PageCount e0292118
ParticipantIDs plos_journals_2876444092
doaj_primary_oai_doaj_org_article_3efe2515277a4f6fb7c4e1002490bba6
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10569505
proquest_miscellaneous_2877380139
proquest_journals_2876444092
gale_infotracmisc_A768669035
gale_infotracacademiconefile_A768669035
gale_incontextgauss_ISR_A768669035
gale_incontextgauss_IOV_A768669035
gale_healthsolutions_A768669035
crossref_primary_10_1371_journal_pone_0292118
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-10-12
PublicationDateYYYYMMDD 2023-10-12
PublicationDate_xml – month: 10
  year: 2023
  text: 2023-10-12
  day: 12
PublicationDecade 2020
PublicationPlace San Francisco
PublicationPlace_xml – name: San Francisco
– name: San Francisco, CA USA
PublicationTitle PloS one
PublicationYear 2023
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References B Benito (pone.0292118.ref009) 2022
EJ Benjamin (pone.0292118.ref022) 2009; 41
RA Espinoza-Lewis (pone.0292118.ref020) 2009; 327
H Chen (pone.0292118.ref011) 2021; 10
BF Gage (pone.0292118.ref016) 2001; 285
J Wang (pone.0292118.ref021) 2010; 107
NHH Heegaard (pone.0292118.ref029) 2016; 11
K Dawson (pone.0292118.ref010) 2013; 127
I Escudero-Martínez (pone.0292118.ref001) 2023; 33
MC Bahit (pone.0292118.ref008) 2021; 144
M Haissaguerre (pone.0292118.ref019) 1998; 339
IE Christophersen (pone.0292118.ref004) 2017; 49
DD McManus (pone.0292118.ref012) 2015; 12
AK Chow (pone.0292118.ref026) 2007; 42
ZI Attia (pone.0292118.ref007) 2019; 394
Z Huang (pone.0292118.ref025) 2016; 9
L Liu (pone.0292118.ref005) 2017; 33
W Whiteley (pone.0292118.ref032) 2009; 40
H Huang (pone.0292118.ref013) 2022; 101
PT Ellinor (pone.0292118.ref003) 2012; 44
Y Natsume (pone.0292118.ref014) 2018; 82
M Yamazoe (pone.0292118.ref015) 2021; 11
L Liu (pone.0292118.ref024) 2000; 278
M Zhang (pone.0292118.ref027) 2021; 78
AG Clausen (pone.0292118.ref028) 2021; 8
Y Okubo (pone.0292118.ref006) 2020; 17
MA Reynolds (pone.0292118.ref031) 2003; 49
MTM Mommersteeg (pone.0292118.ref018) 2007; 101
Y Liu (pone.0292118.ref023) 2014; 9
EM Alanazi (pone.0292118.ref030) 2021; 5
P Kirchhof (pone.0292118.ref002) 2020; 383
C Roselli (pone.0292118.ref017) 2018; 50
References_xml – volume: 82
  start-page: 965
  issue: 4
  year: 2018
  ident: pone.0292118.ref014
  article-title: Combined analysis of human and experimental murine samples identified novel circulating microRNAs as biomarkers for atrial fibrillation.
  publication-title: Circ J
  doi: 10.1253/circj.CJ-17-1194
– volume: 144
  start-page: 1738
  issue: 22
  year: 2021
  ident: pone.0292118.ref008
  article-title: Predictors of Atrial Fibrillation Development in Patients With Embolic Stroke of Undetermined Source: An Analysis of the RE-SPECT ESUS Trial
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.121.055176
– volume: 33
  start-page: 23
  issue: 1
  year: 2023
  ident: pone.0292118.ref001
  article-title: Atrial fibrillation and stroke: A review and new insights
  publication-title: Trends Cardiovasc Med
  doi: 10.1016/j.tcm.2021.12.001
– volume: 49
  start-page: 1733
  issue: 10
  year: 2003
  ident: pone.0292118.ref031
  article-title: Early Biomarkers of Stroke.
  publication-title: Clin Chem
  doi: 10.1373/49.10.1733
– volume: 78
  start-page: 175
  issue: 2
  year: 2021
  ident: pone.0292118.ref027
  article-title: Caveolin-1 Deficiency Induces Atrial Fibrosis and Increases Susceptibility to Atrial Fibrillation by the STAT3 Signaling Pathway
  publication-title: J Cardiovasc Pharmacol
  doi: 10.1097/FJC.0000000000001066
– volume: 107
  start-page: 9753
  issue: 21
  year: 2010
  ident: pone.0292118.ref021
  article-title: Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.0912585107
– volume: 11
  start-page: 5837
  issue: 1
  year: 2021
  ident: pone.0292118.ref015
  article-title: Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation
  publication-title: Sci Rep
  doi: 10.1038/s41598-021-85204-7
– volume: 9
  start-page: e101318
  issue: 7
  year: 2014
  ident: pone.0292118.ref023
  article-title: Genetic Polymorphisms in ZFHX3 Are Associated with Atrial Fibrillation in a Chinese Han Population.
  publication-title: PLoS One.
  doi: 10.1371/journal.pone.0101318
– volume: 41
  start-page: 879
  issue: 8
  year: 2009
  ident: pone.0292118.ref022
  article-title: Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
  publication-title: Nat Genet
  doi: 10.1038/ng.416
– volume: 17
  start-page: 699
  issue: 5, Part A
  year: 2020
  ident: pone.0292118.ref006
  article-title: Predicting atrial fibrillation using a combination of genetic risk score and clinical risk factors
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2020.01.006
– volume: 10
  start-page: 12742
  issue: 12
  year: 2021
  ident: pone.0292118.ref011
  article-title: Relationship between circulating miRNA-21, atrial fibrosis, and atrial fibrillation in patients with atrial enlargement.
  publication-title: Annals of Palliative Medicine
  doi: 10.21037/apm-21-3518
– volume: 101
  start-page: 902
  issue: 9
  year: 2007
  ident: pone.0292118.ref018
  article-title: Pitx2c and Nkx2-5 Are Required for the Formation and Identity of the Pulmonary Myocardium
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.107.161182
– volume: 339
  start-page: 659
  issue: 10
  year: 1998
  ident: pone.0292118.ref019
  article-title: Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199809033391003
– volume: 33
  start-page: 443
  issue: 4
  year: 2017
  ident: pone.0292118.ref005
  article-title: Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population
  publication-title: Can J Cardiol
  doi: 10.1016/j.cjca.2016.10.029
– volume: 11
  start-page: e0160577
  issue: 8
  year: 2016
  ident: pone.0292118.ref029
  article-title: Diurnal Variations of Human Circulating Cell-Free Micro-RNA.
  publication-title: PLoS One.
  doi: 10.1371/journal.pone.0160577
– volume: 5
  start-page: e23440
  issue: 12
  year: 2021
  ident: pone.0292118.ref030
  article-title: Predicting Risk of Stroke From Lab Tests Using Machine Learning Algorithms: Development and Evaluation of Prediction Models.
  publication-title: JMIR Form Res
  doi: 10.2196/23440
– year: 2022
  ident: pone.0292118.ref009
  article-title: Plasma levels of miRNA-1-3p are associated with subclinical atrial fibrillation in patients with cryptogenic stroke
  publication-title: Revista Española de Cardiología (English Edition).
– volume: 394
  start-page: 861
  issue: 10201
  year: 2019
  ident: pone.0292118.ref007
  article-title: An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction
  publication-title: The Lancet
  doi: 10.1016/S0140-6736(19)31721-0
– volume: 127
  start-page: 1466
  issue: 14
  year: 2013
  ident: pone.0292118.ref010
  article-title: MicroRNA29: A Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.112.001207
– volume: 327
  start-page: 376
  issue: 2
  year: 2009
  ident: pone.0292118.ref020
  article-title: Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2008.12.028
– volume: 42
  start-page: 896
  issue: 4
  year: 2007
  ident: pone.0292118.ref026
  article-title: Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2007.01.008
– volume: 101
  start-page: e28980
  issue: 9
  year: 2022
  ident: pone.0292118.ref013
  article-title: Upregulated miR-328-3p and its high risk in atrial fibrillation: A systematic review and meta-analysis with meta-regression.
  publication-title: Medicine
  doi: 10.1097/MD.0000000000028980
– volume: 49
  start-page: 946
  issue: 6
  year: 2017
  ident: pone.0292118.ref004
  article-title: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
  publication-title: Nat Genet
  doi: 10.1038/ng.3843
– volume: 8
  year: 2021
  ident: pone.0292118.ref028
  article-title: Loss-of-Function Variants in the SYNPO2L Gene Are Associated With Atrial Fibrillation.
  publication-title: Frontiers in Cardiovascular Medicine
  doi: 10.3389/fcvm.2021.650667
– volume: 278
  start-page: H1153
  issue: 4
  year: 2000
  ident: pone.0292118.ref024
  article-title: Regulation of DHP receptor expression by elements in the 5′-flanking sequence.
  publication-title: American Journal of Physiology-Heart and Circulatory Physiology.
  doi: 10.1152/ajpheart.2000.278.4.H1153
– volume: 44
  start-page: 670
  issue: 6
  year: 2012
  ident: pone.0292118.ref003
  article-title: Meta-analysis identifies six new susceptibility loci for atrial fibrillation
  publication-title: Nat Genet
  doi: 10.1038/ng.2261
– volume: 383
  start-page: 1305
  issue: 14
  year: 2020
  ident: pone.0292118.ref002
  article-title: Early Rhythm-Control Therapy in Patients with Atrial Fibrillation
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2019422
– volume: 40
  start-page: e380
  issue: 5
  year: 2009
  ident: pone.0292118.ref032
  article-title: Blood Markers for the Prognosis of Ischemic Stroke
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.528752
– volume: 12
  start-page: 3
  issue: 1
  year: 2015
  ident: pone.0292118.ref012
  article-title: Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study).
  publication-title: Heart Rhythm
  doi: 10.1016/j.hrthm.2014.09.050
– volume: 285
  start-page: 2864
  issue: 22
  year: 2001
  ident: pone.0292118.ref016
  article-title: Validation of Clinical Classification Schemes for Predicting StrokeResults From the National Registry of Atrial Fibrillation
  publication-title: JAMA
  doi: 10.1001/jama.285.22.2864
– volume: 9
  start-page: e003396
  issue: 7
  year: 2016
  ident: pone.0292118.ref025
  article-title: Signal Transducer and Activator of Transcription 3/MicroRNA-21 Feedback Loop Contributes to Atrial Fibrillation by Promoting Atrial Fibrosis in a Rat Sterile Pericarditis Model
  publication-title: Circulation Arrhythmia and electrophysiology
  doi: 10.1161/CIRCEP.115.003396
– volume: 50
  start-page: 1225
  issue: 9
  year: 2018
  ident: pone.0292118.ref017
  article-title: Multi-ethnic genome-wide association study for atrial fibrillation
  publication-title: Nat Genet
  doi: 10.1038/s41588-018-0133-9
SSID ssj0053866
Score 2.430791
Snippet Background Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF...
Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as...
BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF...
Background Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF...
SourceID plos
doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e0292118
SubjectTerms Analysis
Arrhythmia
Atrial fibrillation
Biological markers
Biology and Life Sciences
Biomarkers
Cardiac arrhythmia
Chromosomes
Congenital diseases
Diagnosis
Disease
Electrocardiography
Ethylenediaminetetraacetic acid
Evaluation
Fibrillation
Genetic analysis
Genetic aspects
Genetic diversity
Genotyping
Health risk assessment
Health risks
Heart failure
Medicine and Health Sciences
MicroRNA
MicroRNAs
miRNA
Nucleotides
Peripheral blood
Plasma
Polymorphism
Risk factors
Scientific equipment and supplies industry
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical significance
Stroke
Stroke (Disease)
Thoracic surgery
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELXQnrggyoe6UMAgJOCQNom_kmNBVAUJkApFvVm2Y7dRt8lqs3vg3zPjeFeNhAQHLnuI30abmbHnTXb8TMhrJ2ppChkyaUqZ8bopMlsLkTmuXJC-4Y3HVwNfvsrTc_75QlzcOuoLe8JGeeDRcEfMBw85WJRKGR5ksMpxX0Slu9xaE8W2Iedti6lxDYZZLGXaKMdUcZT8crjsO3-YlzVUPdUkEUW9_t2qPFsu-mFCOacNk7cy0Ml9ci9RR3o8_uQ9csd3D8hempwDfZsUpN89JJuzdrimoyJuSC_laB-oiWd00IBt_ouxCY6arkFkf-0p9sBfUvxYeNqh0HG_bhtPl_3i100PDmmHm4h37crFY78Ajvv3scVnNTwi5ycff3w4zdL5CpmTlVhn1vqYwAOksSLIogIyZAvDuQlSWpmHwioWwAFAMYIKjtncMC4ZLApM2Spnj8msA4vuE1oVJq-MEAYIJ1fSAG-zjW9yEQwvrajnJNsaWy9HGQ0d_0tTUH6M5tPoHJ2cMyfv0SM7LIpgxwsQGjqFhv5baMzJC_SnHneU7qayPoYSS8o6Z2JOXkUECmF02GlzaTbDoD99-_kPoO9nE9CbBAo9eNeZtLsBngkFtibIgwkSprObDO9j9G2tMmgoaYGzQhlewje3Efnn4Ze7Ybwpds91vt9EjGIVkv05qSaRPDHwdKRrr6LaOBBwWQNPfvI_XPKU3C2BJWaxJeiAzNarjX8GrG5tn8cJ_BtNZU1-
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lj9MwELagXLggloe2ywIGIQGH7ObhR3JCC6IsSIC0sGhvke3YJdpuXJr2wL9nxnELkRDi0kP8NU1nPDOfnfEMIc8Mr4TKhEuEykXCqiZLdMV5Ypg0TtiGNRa3Bj5-Eqfn7MMFv4gbbn1Mq9z6xOCoG29wj_wYmD2EbliN5K-WPxLsGoVvV2MLjevkRgaRBlO6ytm7rScGWxYiHpcrZHYctXO09J09SvMK1j7lKByFqv073zxZLnw_Ip7jtMk_4tDsNrkVCSQ9GTS-R67Z7g7Ziyba0xexjvTLu2Rz1vaXdKiL6-LWHPWOqtCpgzpM9l8MqXBUdQ0i_aWlmAk_p_ixsLTDcsd-3TaWLv3i55UHtbT9VcCbdmVC8y-A4yl-TPRZ9ffI-ezt1zenSeyykBhR8nWitQ1h3EEwy5zISqBEOlOMKSeEFqnLtCxcYR0QDSedKXSqCiYKcA2F1GVa3CeTDiS6T2iZqbRUnCugnUwKBexNN7ZJuVMs17yakmQr7Ho5FNOowxs1CYuQQXw1KqeOypmS16iRHRZLYYcLfjWvo2XV8GQWSBrPpVTMCaelYTYLpRBTrZWYkseoz3o4V7oz6PoEFlpCVGnBp-RpQGA5jA7zbeZq0_f1-8_f_gP05WwEeh5BzoN2jYpnHOA_YZmtEfJwhASjNqPhfZx9W6n09e_pD9_czsi_Dz_ZDeNNMYeus34TMLIokfJPSTmaySMBj0e69nuoOQ40XFTAlg_-_esPyM0cWGASUn4OyWS92tiHwNrW-lEwzV-Ks0UE
  priority: 102
  providerName: ProQuest
Title Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers
URI https://www.proquest.com/docview/2876444092
https://www.proquest.com/docview/2877380139
https://pubmed.ncbi.nlm.nih.gov/PMC10569505
https://doaj.org/article/3efe2515277a4f6fb7c4e1002490bba6
http://dx.doi.org/10.1371/journal.pone.0292118
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELe27oUXxPjQCqMYhAQ8pMqHP5IHhLapZSBtoEJR3yI7sUu0LilNK7EX_nbunLQi0pD24of6F6u588W_s893hLzOeCJUIKwnVCg8luSBpxPOvYzJzAqTs9zg1sDFpTifss8zPtsj25qtrQDrW107rCc1XS2Gv3_dfACDf--qNshg-9BwWZVm6IcJ-DTxPjmAtUliTYMLtjtXAOt2p5fIWjwR-lF7me5_o3QWK5fTf_fl7i0XVd2hpd2gyn9WqfEDcr-ll_SkmQ-HZM-UD8lha8A1fdtmmX73iGwmRX1Fm6y5tt24o5WlytXxoBavAiyaQDmqyhyR1ZWhGCc_p9gsDC0xGXK1LnJDl9Xi5roCpRX1tcNnxSpzpcEAjnf8MQxoVT8m0_Ho-9m519Zg8DIR87WntXGLvIWlLrAiiIEw6UAxpqwQWvg20DKykbFAQ6y0WaR9FTERwYcjkjr2oyekV4JEjwiNA-XHinMFpJRJoYDb6dzkPreKhZonfeJthZ0um1QbqTtvk-CiNOJLUTlpq5w-OUWN7LCYKNv9UK3maWt3KfwzAxSOh1IqZoXVMmMmcIkSfa2V6JMXqM-0uXW6M_f0BNwwIRI_4n3yyiEwWUaJ0Thztanr9NOXH3cAfZt0QG9akK1Au5lqb0DAO2ESrg7yuIMEk8863Uc4-7ZSqVNwe4HXgqsewpPbGXl798tdNw6KEXalqTYOI6MYHYI-iTszuSPgbk9Z_HQZyYGkiwS49NM7DP-M3AuBKHouKuiY9NarjXkOxG6tB2RfziS08VmA7fjjgBycji6_TgZuq2TgbBnbP6O_a4dVDw
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VcIALojzUQKELAgEHt7b3YfuAUHmEhD6QSlv1Znbt3RA1tUOcCPVP8RuZWdsBSwhx6SUH72cnmZmdx3oehDzLRCJVIK0nVSg9nuSBpxMhvIxHmZUm57nBo4GDQzk84Z_OxNka-dnWwmBaZasTnaLOywzPyHfAswfTDdFI-Gb23cOpUfh2tR2hUYvFnrn8ASFb9Xr0Hvj7PAwHH47fDb1mqoCXyVgsPK2NM1sWlHdgZRCDC6ADxbmyUmrp20BHzDJjwbDayGZM-4pxyWArsEjHPoPnXiPXOQNLjpXpg4-t5gfdIWVTnseiYKeRhu1ZWZhtP0wg1oo75s9NCVjZgt5sWlYdR7ebpvmH3RvcJrcah5Xu1hK2TtZMcYesNyqhoi-bvtWv7pLl0aQ6p3UfXtscBdLSUuUmg1CLxQXTOvWOqiJHZHluKGbejyl-TA0tsL1yuZjkhs7K6eVFCWIwqS4cPpvMMzdsDODYNQATi-bVPXJyJfS_T3oFUHSD0DhQfqyEUODm8kgq8BZ1bnJfWMVDLZI-8Vpip7O6eUfq3uBFEPTU5EuROWnDnD55ixxZYbH1trtQzsdps5NT-GUGnEIRRpHiVlodZdwErvWir7WSfbKF_EzrOtaVAkl3IbCTMvGZ6JOnDoHtNwrM7xmrZVWlo8-n_wH6ctQBvWhAtgTuZqqpqYD_hG29OsjNDhKUSNZZ3kDpa6lSpb-3G9zZSuTfl5-slvGhmLNXmHLpMBGLMcTok7gjyR0Cd1eKyTfX4xzcfpmAd_7g39--RW4Mjw_20_3R4d5DcjMED9Rz6UabpLeYL80j8BgX-rHbppR8vWq98Au53IBm
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VICEuiPJQQwtdEAg4uPFjvWsfECotUUOhoEJRb2bX3k2jpnaIE6H-NX4dM-t1wBJCXHrJwfvZSWZm57GeByFP8zjlMuDG4zLkHkuLwFNpHHs5E7nhumCFxqOBD0f84IS9O41P18jPthYG0ypbnWgVdVHleEY-AM8eTDdEI-HAuLSIT_vD17PvHk6Qwjet7TiNRkQO9eUPCN_qV6N94PWzMBy-_bJ34LkJA17Ok3jhKaWtCTOgyAPDgwTcARVIxqThXHHfBEpEJtIGjKwRJo-ULyPGI9gWkVCJH8Fzr5HrIhIJ7rFkb5VeAnqEc1eqF4lg4CRjZ1aVescPU4i7ko4ptBMDVnahN5tWdcfp7aZs_mEDh7fJLee80t1G2tbJmi7vkHWnHmr6wvWwfnmXLI8n9TltevIadyxIK0OlnRJCDRYaTJs0PCrLApHVuaaYhT-m-DHVtMRWy9ViUmg6q6aXFxWIxKS-sPh8Ms_t4DGAYwcBTDKa1_fIyZXQ_z7plUDRDUKTQPqJjGMJLi8TXILnqApd-LGRLFRx2ideS-xs1jTyyOzbPAEBUEO-DJmTOeb0yRvkyAqLbbjthWo-ztyuzuCXaXAQ41AIyQw3SuRMB7YNo6-U5H2yjfzMmprWlTLJdiHI4zz1o7hPnlgEtuIoUajHclnX2ejj1_8AfT7ugJ47kKmAu7l09RXwn7DFVwe51UGCQsk7yxsofS1V6uz31oM7W4n8-_Lj1TI-FPP3Sl0tLUZECYYbfZJ0JLlD4O5KOTmz_c4hBOApeOoP_v3t2-QGaITs_ejocJPcDMEZ9Wzm0RbpLeZL_RCcx4V6ZHcpJd-uWi38AiYwhGc
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Risk+stratification+of+atrial+fibrillation+and+stroke+using+single+nucleotide+polymorphism+and+circulating+biomarkers&rft.jtitle=PloS+one&rft.au=Sasano%2C+Tetsuo&rft.au=Ihara%2C+Kensuke&rft.au=Tanaka%2C+Toshihiro&rft.au=Furukawa%2C+Tetsushi&rft.date=2023-10-12&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=18&rft.issue=10&rft.spage=e0292118&rft_id=info:doi/10.1371%2Fjournal.pone.0292118&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon