Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

• Published in: Journal of allergy and clinical immunology Vol. 129; no. 5; pp. 1387 - 1396.e7
• Main Authors: Kagalwalla, Amir F., Akhtar, Noorain, Woodruff, Samantha A., Rea, Bryan A., Masterson, Joanne C., Mukkada, Vincent, Parashette, Kalyan R., Du, Jian, Fillon, Sophie, Protheroe, Cheryl A., Lee, James J., Amsden, Katie, Melin-Aldana, Hector, Capocelli, Kelley E., Furuta, Glenn T., Ackerman, Steven J.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.2012; Elsevier; Elsevier Limited
• Subjects: Adolescent; adrenal cortex hormones; Adrenal Cortex Hormones - therapeutic use; Allergy and Immunology; Biological and medical sciences; biomarkers; Biopsy; Cell culture; Child; Child, Preschool; Children; Children & youth; Corticoids; Cytokeratin; diet; Diet Therapy; Diets; Disease Progression; Elemental diet; Eosinophil; Eosinophilic Esophagitis - pathology; Eosinophilic Esophagitis - physiopathology; Eosinophilic Esophagitis - therapy; eosinophils; Eosinophils - metabolism; Eosinophils - pathology; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelial-Mesenchymal Transition - drug effects; epithelium; Esophagitis; Esophagus; Esophagus - drug effects; Esophagus - pathology; Female; Fibronectin; fibronectins; Fibrosis; Food; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Gastroesophageal reflux; Gene expression; gene expression regulation; genes; Humans; Immunohistochemistry; Immunopathology; Infant; Inflammation; Keratins - metabolism; Leukocytes (eosinophilic); Male; Medical sciences; mesenchymal; Mesenchyme; Microscopy; N-Cadherin; Other diseases. Semiology; Pediatrics; Peroxidase; Remission; Remission Induction; remodeling; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Transforming Growth Factor beta - metabolism; Transforming growth factor- beta; Transforming growth factor- beta 1; Vimentin; Vimentin - metabolism; remodeling; esophagitis; PPI; vimentin; cytokeratin; EPX; EMT; Eosinophil; TC; GERD; SFED; mesenchymal; RT-Q-PCR; epithelium; fibrosis; EoE; ED; hpf; Eosinophil peroxidase; Elemental diet; Proton pump inhibitor; Topical corticosteroid; Six-food elimination diet; Reverse-transcriptase quantitative polymerase chain reaction; Eosinophilic esophagitis; High-power field; Gastroesophageal reflux disease; Epithelial mesenchymal transition; Vimentin; Cytokeratin; Immunopathology; Digestive system; Esophageal disease; Granulocyte; Mesenchyma; Esophagitis; Mesenchymal cell; Epithelium; Cell transformation; Remodeling; Esophagus; Immunology; Treatment; Fibrosis; Digestive diseases; Reversibility

Mechanisms underlying esophageal remodeling with subepithelial fibrosis in subjects with eosinophilic esophagitis (EoE) have not been delineated. We sought to explore a role for epithelial mesenchymal transition (EMT) in subjects with EoE and determine whether EMT resolves with treatment. Esophageal...