Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment - Kagalwalla, Amir F.; Akhtar, Noorain; Woodruff, Samantha A.; Rea, Bryan A.; Masterson, Joanne C.; Mukkada, Vincent; Parashette, Kalyan R.; Du, Jian; Fillon, Sophie; Protheroe, Cheryl A.; Lee, James J.; Amsden, Katie; et al. (Journal of allergy and clinical immunology, 2012)
Keywords: Adolescent; adrenal cortex hormones; Adrenal Cortex Hormones - therapeutic use; Allergy and Immunology; Biological and medical sciences; biomarkers; Biopsy; Cell culture; Child; Child, Preschool; Children; Children & youth; Corticoids; Cytokeratin; diet; Diet Therapy; Diets; Disease Progression; Elemental diet; Eosinophil; Eosinophilic Esophagitis - pathology; Eosinophilic Esophagitis - physiopathology; Eosinophilic Esophagitis - therapy; eosinophils; Eosinophils - metabolism; Eosinophils - pathology; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelial-Mesenchymal Transition - drug effects; epithelium; Esophagitis; Esophagus; Esophagus - drug effects; Esophagus - pathology; Female; Fibronectin; fibronectins; Fibrosis; Food; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Gastroesophageal reflux; Gene expression; gene expression regulation; genes; Humans; Immunohistochemistry; Immunopathology; Infant; Inflammation; Keratins - metabolism; Leukocytes (eosinophilic); Male; Medical sciences; mesenchymal; Mesenchyme; Microscopy; N-Cadherin; Other diseases. Semiology; Pediatrics; Peroxidase; Remission; Remission Induction; remodeling; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Transforming Growth Factor beta - metabolism; Transforming growth factor- beta; Transforming growth factor- beta 1; Vimentin; Vimentin - metabolism; remodeling; esophagitis; PPI; vimentin; cytokeratin; EPX; EMT; Eosinophil; TC; GERD; SFED; mesenchymal; RT-Q-PCR; epithelium; fibrosis; EoE; ED; hpf; Eosinophil peroxidase; Elemental diet; Proton pump inhibitor; Topical corticosteroid; Six-food elimination diet; Reverse-transcriptase quantitative polymerase chain reaction; Eosinophilic esophagitis; High-power field; Gastroesophageal reflux disease; Epithelial mesenchymal transition