Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment

• Published in: Thrombosis and haemostasis Vol. 99; no. 1; p. 121
• Main Authors: Sibbing, Dirk, Braun, Siegmund, Jawansky, Stefan, Vogt, Wolfgang, Mehilli, Julinda, Schömig, Albert, Kastrati, Adnan, von Beckerath, Nicolas
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2008
• Subjects: Adenosine Diphosphate; Aged; Electrodes; Female; Humans; Light; Male; Middle Aged; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; Platelet Function Tests - instrumentation; Platelet Function Tests - methods; Platelet Function Tests - standards; Reproducibility of Results; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology; Ticlopidine - therapeutic use; Time Factors

The level of platelet aggregation, measured with light transmission aggregometry (LTA) in platelet rich plasma (PRP), has been shown to predict outcomes after percutaneous coronary intervention (PCI). However, measuring parameters of platelet function with LTA is time consuming and weakly standardiz...