Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects

• Published in: Vaccine Vol. 33; no. 39; pp. 5225 - 5234
• Main Authors: Frey, Sharon E., Wald, Anna, Edupuganti, Srilatha, Jackson, Lisa A., Stapleton, Jack T., Sahly, Hana El, El-Kamary, Samer S., Edwards, Kathryn, Keyserling, Harry, Winokur, Patricia, Keitel, Wendy, Hill, Heather, Goll, Johannes B., Anderson, Edwin L., Graham, Irene L., Johnston, Christine, Mulligan, Mark, Rouphael, Nadine, Atmar, Robert, Patel, Shital, Chen, Wilbur, Kotloff, Karen, Creech, C. Buddy, Chaplin, Paul, Belshe, Robert B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 22.09.2015; Elsevier Limited
• Subjects: Adolescent; Adult; Allergy and Immunology; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Antigens; Chemistry, Pharmaceutical; Confidence intervals; Discoloration; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; ELISA; erythema; Female; freeze drying; geometry; Heart attacks; Humans; immune response; Immunization; Immunogenicity; IMVAMUNE; injection site; Injections, Intradermal; Injections, Subcutaneous; Intradermal; Lyophilized; Male; MVA; NCT00914732; Neutralization; Plaque reduction neutralizing antibody; seroprevalence; shelf life; Smallpox; Smallpox Vaccine - administration & dosage; Smallpox Vaccine - adverse effects; Smallpox Vaccine - immunology; Subcutaneous; United States; vaccination; Vaccines; Vaccinia-naïve; Variola; Variola virus; Young Adult; United States; IMVAMUNE; Plaque reduction neutralizing antibody; Smallpox; Vaccinia-naïve; Subcutaneous; Intradermal; NCT00914732; Variola; MVA; Lyophilized; ELISA

•Lyophilized MVA was more immunogenic than the current liquid formulation of MVA.•The lower ID dose of MVA was immunologically non-inferior to the standard SC dose.•The ID route resulted in more erythema and/or induration than the SC route.•The ID route may increase the number of available doses in...