Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-naïve subjects - Frey, Sharon E.; Wald, Anna; Edupuganti, Srilatha; Jackson, Lisa A.; Stapleton, Jack T.; Sahly, Hana El; El-Kamary, Samer S.; Edwards, Kathryn; Keyserling, Harry; Winokur, Patricia; Keitel, Wendy; Hill, Heather; et al. (Vaccine, 2015)
Keywords: Adolescent; Adult; Allergy and Immunology; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Antigens; Chemistry, Pharmaceutical; Confidence intervals; Discoloration; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; ELISA; erythema; Female; freeze drying; geometry; Heart attacks; Humans; immune response; Immunization; Immunogenicity; IMVAMUNE; injection site; Injections, Intradermal; Injections, Subcutaneous; Intradermal; Lyophilized; Male; MVA; NCT00914732; Neutralization; Plaque reduction neutralizing antibody; seroprevalence; shelf life; Smallpox; Smallpox Vaccine - administration & dosage; Smallpox Vaccine - adverse effects; Smallpox Vaccine - immunology; Subcutaneous; United States; vaccination; Vaccines; Vaccinia-naïve; Variola; Variola virus; Young Adult; United States; IMVAMUNE; Plaque reduction neutralizing antibody; Smallpox; Vaccinia-naïve; Subcutaneous; Intradermal; NCT00914732; Variola; MVA; Lyophilized; ELISA