Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

• Published in: Nature genetics Vol. 41; no. 7; pp. 776 - 782
• Main Authors: De Jager, Philip L, Jia, Xiaoming, Wang, Joanne, de Bakker, Paul I W, Ottoboni, Linda, Aggarwal, Neelum T, Piccio, Laura, Raychaudhuri, Soumya, Tran, Dong, Aubin, Cristin, Briskin, Rebeccah, Romano, Susan, Baranzini, Sergio E, McCauley, Jacob L, Pericak-Vance, Margaret A, Haines, Jonathan L, Gibson, Rachel A, Naeglin, Yvonne, Uitdehaag, Bernard, Matthews, Paul M, Kappos, Ludwig, Polman, Chris, McArdle, Wendy L, Strachan, David P, Evans, Denis, Cross, Anne H, Daly, Mark J, Compston, Alastair, Sawcer, Stephen J, Weiner, Howard L, Hauser, Stephen L, Hafler, David A, Oksenberg, Jorge R
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2009; Nature Publishing Group
• Subjects: Agriculture; Animal Genetics and Genomics; Antigens, CD - genetics; Antigens, Differentiation, T-Lymphocyte - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Care and treatment; Case-Control Studies; Data base management; DNA replication; Fundamental and applied biological sciences. Psychology; Gene Function; Gene loci; Genetic aspects; Genetic Predisposition to Disease; Genetic susceptibility; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Heart attacks; Human Genetics; Humans; Inflammatory diseases; Inflation; Interferon Regulatory Factors - genetics; Medical sciences; Meta-analysis; Methods; Molecular and cellular biology; Molecular genetics; Multiple sclerosis; Multiple Sclerosis - genetics; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurological disorders; Neurology; Oligonucleotide Array Sequence Analysis; Physiological aspects; Receptors, Tumor Necrosis Factor, Type I - genetics; Regression analysis; Replication; Risk factors; Stratigraphy; United States; United Kingdom; Nervous system diseases; Multiple sclerosis; Central nervous system disease; Replication; Identification; Genome; Locus; Inflammatory disease; Metaanalysis

Philip De Jager and colleagues report results of a large genome-wide association and replication study for multiple sclerosis. The work uncovers three new susceptibility loci for MS, including common and rare variants at TNFRSF1A and common variants at IRF8 and CD6 . We report the results of a meta-...