An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects

Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that so...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of clinical nutrition Vol. 65; no. 5; pp. 648 - 656
Main Authors Alavi, A, Fraser, O, Tarelli, E, Bland, M, Axford, J
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2011
Nature Publishing Group
Subjects
631/45/72/1201
631/92/436
692/700/459/1994
Adult
Biological and medical sciences
Biopolymers
blood proteins
blood serum
Carbohydrates
Clinical Nutrition
dietary carbohydrate
Dietary Carbohydrates - administration & dosage
Dietary fiber
Dietary supplements
Dietary Supplements - adverse effects
dose response
Dose-Response Relationship, Drug
Epidemiology
Feeding. Feeding behavior
Female
Flowers & plants
Fluctuations
Food safety
Fundamental and applied biological sciences. Psychology
Glycoproteins
Glycoproteins - blood
Glycosylation
Health aspects
Humans
immunomodulators
Ingestion
Internal Medicine
Male
Mass spectrometry
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Nutrition research
Original
original-article
Physiological aspects
Pilot Projects
Plants - chemistry
Polysaccharides
Polysaccharides - administration & dosage
Polysaccharides - blood
Public Health
Regression analysis
Saccharides
Safety
Vertebrates: anatomy and physiology, studies on body, several organs or systems
United Kingdom
Serum glycosylation
sialylation
glycans
dietary fiber
dietary plant polysaccharides
glycomodifications
Healthy subject
Toxicity
Glycoprotein
Label
Metabolic diseases
Glycosylation
N-glycans
Posology
Feeding
Plant
Diet
Serum
Supplementation
Dietary fiber
Polysaccharide
Food supplement
Dietary plant polysaccharides
Glycomodifications
Sialylation
Online AccessGet full text
ISSN0954-3007
1476-5640
1476-5640
DOI10.1038/ejcn.2010.263

Cover

Abstract Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Objective: Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N- glycosylation status of serum glycoproteins in a cohort of healthy individuals. Design: An open-label study was carried out. This study was in two phases: pilot study ( n =6 individuals) to assess safety and dose, and a larger study ( n =12) to evaluate specific glycosylation changes. Serum N- glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3–5.2 g/day). Results: No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N- glycans ( P <0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient −0.130 decrease/week: P =0.02 and −0.690: P =0.005), and a concomitant increase in disialylated glycans ( × 1.083: P <0.05). Conclusions: Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N- glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.
AbstractList The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals. An open-label study was carried out. This study was in two phases: pilot study (n=6 individuals) to assess safety and dose, and a larger study (n=12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3-5.2 g/day). No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (P<0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient -0.130 decrease/week: P=0.02 and -0.690: P=0.005), and a concomitant increase in disialylated glycans ( × 1.083: P<0.05). Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.
European Journal of Clinical Nutrition (2011) 65, 648-656; doi: 10.1038/ejcn.2010.263; published online 12 January 2011
Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and / immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Objective: Examine the impact of oral ingestion of a standardized dietary plant derived polydisperse polysaccharide supplement (AA) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals. Design: An open label study was used. The study was in two phases; pilot study (n=6 individuals) to assess safety and dose, and a larger study (n=12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for seven weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further seven weeks, during which time increasing doses of AA were ingested (1.3-5.2 g/day). Results: No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (p<0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose dependent decrease in mono- and di-galactosylated structures (coefficient −0.130 decrease/week: p=0.02 and −0.690: p=0.005), and a concomitant increase in disilaylated glycans (x1.083: p<0.05). Conclusions: Supplementation with the dietary plant derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.
Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Objective: Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals. Design: An open-label study was carried out. This study was in two phases: pilot study (n = 6 individuals) to assess safety and dose, and a larger study (n = 12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3-5.2 g/day). Results: No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (P<0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient -0.130 decrease/week: P = 0.02 and - 0.690: P = 0.005), and a concomitant increase in disialylated glycans (x 1.083: P<0.05). Conclusions: Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated. European Journal of Clinical Nutrition (2011) 65, 648-656; doi: 10.1038/ejcn.2010.263; published online 12 January 2011 Keywords: dietary plant polysaccharides; Serum glycosylation; N-glycans; dietary fiber; glycomodifications; sialylation
Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Objective: Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals. Design: An open-label study was carried out. This study was in two phases: pilot study (n=6 individuals) to assess safety and dose, and a larger study (n=12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3–5.2g/day). Results: No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (P<0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient −0.130 decrease/week: P=0.02 and −0.690: P=0.005), and a concomitant increase in disialylated glycans (× 1.083: P<0.05). Conclusions: Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.
Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Objective: Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N- glycosylation status of serum glycoproteins in a cohort of healthy individuals. Design: An open-label study was carried out. This study was in two phases: pilot study ( n =6 individuals) to assess safety and dose, and a larger study ( n =12) to evaluate specific glycosylation changes. Serum N- glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3–5.2 g/day). Results: No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N- glycans ( P <0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient −0.130 decrease/week: P =0.02 and −0.690: P =0.005), and a concomitant increase in disialylated glycans ( × 1.083: P <0.05). Conclusions: Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N- glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.
Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation. Objective: Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals. Design: An open-label study was carried out. This study was in two phases: pilot study (n 6 individuals) to assess safety and dose, and a larger study (n 12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.35.2 g/day). Results: No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (Po0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient 0.130 decrease/week: P 0.02 and 0.690: P 0.005), and a concomitant increase in disialylated glycans ( 1.083: Po0.05). Conclusions: Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated. [PUBLICATION ABSTRACT]
The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation.BACKGROUNDThe functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and in-vivo studies suggest that certain dietary saccharide biopolymers can have bifidogenic and or immunomodulatory effects, and that some could represent preferential substrates or precursors that can impact cellular glycosylation.Examine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals.OBJECTIVEExamine the impact of oral ingestion of a standardized dietary plant-derived polydisperse polysaccharide supplement (Advanced Ambrotose powder (AA)) on the N-glycosylation status of serum glycoproteins in a cohort of healthy individuals.An open-label study was carried out. This study was in two phases: pilot study (n=6 individuals) to assess safety and dose, and a larger study (n=12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3-5.2 g/day).DESIGNAn open-label study was carried out. This study was in two phases: pilot study (n=6 individuals) to assess safety and dose, and a larger study (n=12) to evaluate specific glycosylation changes. Serum N-glycosylation profiles, using mass spectrometry, were monitored at weekly intervals, for 7 weeks, to evaluate baseline levels and normal fluctuations. The individuals were then monitored for a further 7 weeks, during which time increasing doses of AA were ingested (1.3-5.2 g/day).No adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (P<0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient -0.130 decrease/week: P=0.02 and -0.690: P=0.005), and a concomitant increase in disialylated glycans ( × 1.083: P<0.05).RESULTSNo adverse events were encountered. AA supplementation resulted in distinct changes in the relative intensities of seven biantennary N-glycans (P<0.001), and a significant overall shift towards increased sialylation. Regression analysis revealed a dose-dependent decrease in mono- and di-galactosylated structures (coefficient -0.130 decrease/week: P=0.02 and -0.690: P=0.005), and a concomitant increase in disialylated glycans ( × 1.083: P<0.05).Supplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.CONCLUSIONSSupplementation with the dietary plant-derived polysaccharides in AA resulted in significant changes in serum protein N-glycosylation in healthy individuals. How this occurs and whether it has biological significance remains to be evaluated.
Audience Professional
Academic
Author Tarelli, E
Fraser, O
Axford, J
Bland, M
Alavi, A
Author_xml – sequence: 1
  givenname: A
  surname: Alavi
  fullname: Alavi, A
  email: aalavi@sgul.ac.uk
  organization: Division of Cellular and Molecular Medicine, The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London
– sequence: 2
  givenname: O
  surname: Fraser
  fullname: Fraser, O
  organization: Division of Cellular and Molecular Medicine, The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London
– sequence: 3
  givenname: E
  surname: Tarelli
  fullname: Tarelli, E
  organization: Division of Bi- Medical Sciences, The Biomics Centre, St George's University of London
– sequence: 4
  givenname: M
  surname: Bland
  fullname: Bland, M
  organization: Department of Health Sciences, University of York
– sequence: 5
  givenname: J
  surname: Axford
  fullname: Axford, J
  organization: Division of Cellular and Molecular Medicine, The Sir Joseph Hotung Centre for Musculoskeletal Disorders, St George's University of London
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24108595$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/21224866$$D View this record in MEDLINE/PubMed
https://hal.science/hal-00608019$$DView record in HAL
BookMark eNp9k8uO0zAUhiM0iJkpLNkiC8RtkcG5OckGqRoBgzSCDawt1zluXbl2sJ1KeTZejpO2zE0FeRHl-Pt_-1x8npxYZyFJnmf0IqNF8wHW0l7kFH9zVjxKzrKyZmnFSnqSnNG2KtOC0vo0OQ9hTSlu1vmT5DTP8rxsGDtLfs8tcT3Y1IgFGNK5oO2ShDh0I4mOwFaYQUQgcQUkCAVxJMJ2BJQCGQNxigjSaYjCj6Q3wsa0A6-30JHemTEIKVfC6w7FQ98b2ICNxNmd3bd0aUbpwmhE1BgLUcRhZxnADxuy2-29i6BtINqSFQgTVyNaLdbT6U-Tx0qYAM8O31ny8_OnH5dX6fX3L18v59epZE0V07Ysi7JWeBWgC9ZmuaSVzKGsFOBSQqm6a0HKXIqFEEVb0GYhy7pqOshQCcUs-bj37YfFBjqJOXhheO_1BtPmTmh-f8fqFV-6LUenumkrNHi_N1g9kF3Nr_kUo5TRhmbtNkP27eEw734NECLf6CDBYG3BDYE3rGwZK5rJ9d1_yZxOtrTEuZglLx-gazd4i0Wb_FiRtVmD0Ks9tBQGuLbKYTJy8uTzHCeqqllDkUqPUEuwgJnjaCqN4Xv8xREeVwcbLY8K3twR7HsenBmmGQn3wRd323JT2L_DjcDrAyCCFEZ5YaUOt1yZ0abateeQkvQuBA_qBskonx4Znx4Znx4Zx2IiXzzgpY67GcbUtPmn6lCIgO52Cf62B8cFfwCKXTyb
CitedBy_id crossref_primary_10_1007_s10482_012_9821_0
crossref_primary_10_1016_S1875_5364_17_30042_0
crossref_primary_10_3168_jds_2020_19297
crossref_primary_10_1179_1476830513Y_0000000101
crossref_primary_10_1007_s11482_011_9158_2
crossref_primary_10_1093_glycob_cwx024
crossref_primary_10_3390_nu12061751
crossref_primary_10_1152_ajpcell_00244_2019
crossref_primary_10_1186_s12970_019_0281_z
Cites_doi 10.1093/ajcn/84.5.1062
10.1016/j.jacl.2009.04.054
10.2174/138161209788489159
10.1016/j.nutres.2009.03.005
10.1016/S0192-0561(99)00085-5
10.1016/j.sbi.2009.06.003
10.1002/jps.21684
10.1172/JCI118777
10.1254/jphs.08204FP
10.1615/CritRevImmunol.v27.i2.10
10.1017/S0007114508055608
10.1016/j.intimp.2005.10.005
10.1007/s10620-009-0848-7
10.1016/j.intimp.2009.07.015
10.2147/VHRM.S3512
10.1016/j.imlet.2006.01.009
10.1111/j.1574-6941.2007.00314.x
10.1016/j.nut.2008.04.005
10.1016/j.mib.2009.04.007
10.1002/ptr.2723
10.2466/pms.108.1.259-270
10.1093/rheumatology/ken081
10.1271/bbb.90326
10.1093/jn/138.1.123
10.2174/138920009787048383
10.1136/jech.2008.082214
10.1016/j.fsi.2008.04.008
10.1093/jn/138.3.439
10.2174/138161209788168182
10.1016/j.imlet.2007.10.016
10.1002/mnfr.200700121
10.1093/glycob/cwm014
10.1096/fj.08-106617
10.2174/157489209788452858
10.1016/S0300-9084(03)00039-7
10.1126/science.1154315
10.1007/s11010-006-9409-y
10.1016/j.mrfmmm.2009.07.011
10.1186/1472-6882-9-49
10.1186/1756-8722-2-25
10.1016/j.fct.2007.09.103
10.1016/j.mehy.2009.04.027
10.1016/j.clnu.2009.01.008
10.1002/jcp.21050
ContentType Journal Article
Copyright The Author(s) 2011
2015 INIST-CNRS
COPYRIGHT 2011 Nature Publishing Group
Copyright Nature Publishing Group May 2011
Distributed under a Creative Commons Attribution 4.0 International License
Copyright © 2011 Macmillan Publishers Limited 2011 Macmillan Publishers Limited
Copyright_xml – notice: The Author(s) 2011
– notice: 2015 INIST-CNRS
– notice: COPYRIGHT 2011 Nature Publishing Group
– notice: Copyright Nature Publishing Group May 2011
– notice: Distributed under a Creative Commons Attribution 4.0 International License
– notice: Copyright © 2011 Macmillan Publishers Limited 2011 Macmillan Publishers Limited
DBID C6C
AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QP
7RV
7TK
7X2
7X7
7XB
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AEUYN
AFKRA
AN0
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
HCIFZ
K9.
KB0
LK8
M0K
M0S
M1P
M2O
M7P
MBDVC
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7S9
L.6
7X8
1XC
VOOES
5PM
DOI 10.1038/ejcn.2010.263
DatabaseName Springer Nature OA Free Journals
CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Nursing & Allied Health Database
Neurosciences Abstracts
Agricultural Science Collection
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
British Nursing Database
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Biological Sciences
Agriculture Science Database
ProQuest Health & Medical Collection
Medical Database
Research Library
Biological Science Database
Research Library (Corporate)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
SciTech Premium Collection
ProQuest Central China
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Agricultural & Environmental Science Collection
ProQuest Research Library
ProQuest Public Health
ProQuest Central Basic
British Nursing Index with Full Text
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Central (Alumni)
AGRICOLA
AGRICOLA - Academic
MEDLINE - Academic
DatabaseTitleList MEDLINE




AGRICOLA

Agricultural Science Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Public Health
Anatomy & Physiology
Diet & Clinical Nutrition
DocumentTitleAlternate Dietary plant-derived polysaccharide supplement
EISSN 1476-5640
EndPage 656
ExternalDocumentID PMC3087895
oai_HAL_hal_00608019v1
2336676271
A256457680
21224866
24108595
10_1038_ejcn_2010_263
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United Kingdom
GeographicLocations_xml – name: United Kingdom
GroupedDBID ---
-ET
-Q-
.GJ
0R~
29G
2WC
36B
39C
4.4
406
53G
5GY
5RE
6PF
70F
7RV
7X2
7X7
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8R4
8R5
A8Z
AACDK
AAHBH
AAIKC
AAMNW
AANZL
AASML
AATNV
AAWTL
AAYZH
ABAKF
ABAWZ
ABBRH
ABCQX
ABDBE
ABDBF
ABFSG
ABJNI
ABLJU
ABOCM
ABRTQ
ABUWG
ABZZP
ACAOD
ACGFO
ACGFS
ACKTT
ACMJI
ACPRK
ACRQY
ACSTC
ACUHS
ACZOJ
ADBBV
ADFRT
ADHUB
AEFQL
AEJRE
AEMSY
AENEX
AEUYN
AEVLU
AEXYK
AEZWR
AFBBN
AFDZB
AFHIU
AFKRA
AFRAH
AFSHS
AGAYW
AGHAI
AGQEE
AHMBA
AHSBF
AHWEU
AI.
AIGIU
AILAN
AIXLP
AJRNO
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMYLF
AN0
APEBS
ATCPS
ATHPR
AXYYD
AYFIA
AZQEC
B0M
BAWUL
BBNVY
BENPR
BHPHI
BKEYQ
BKKNO
BKOMP
BNQBC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DNIVK
DPUIP
DU5
DWQXO
E.L
E3Z
EAD
EAP
EAS
EBC
EBD
EBLON
EBO
EBS
ECGQY
EE.
EHN
EIHBH
EIOEI
EJD
EMB
EMK
EMOBN
EPL
EPT
ESX
EX3
F5P
FDQFY
FERAY
FIGPU
FIZPM
FSGXE
FYUFA
GNUQQ
GUQSH
HCIFZ
HMCUK
HZ~
IAG
IAO
ICU
IEA
IHR
IHT
IHW
INH
INR
IOF
ITC
IWAJR
JSO
JZLTJ
KQ8
LGEZI
LOTEE
M0K
M1P
M2O
M7P
NADUK
NAPCQ
NQJWS
NXXTH
O9-
OK1
OVD
P2P
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
Q2X
Q~Q
RNS
RNT
RNTTT
ROL
RXW
SNX
SNYQT
SOHCF
SOJ
SRMVM
SV3
SWTZT
TAE
TAOOD
TBHMF
TDRGL
TEORI
TH9
TR2
TSG
TUS
UKHRP
VH1
WH7
WOW
XOL
ZXP
~02
~8M
~KM
AAYXX
ACMFV
CITATION
IQODW
3V.
AAZLF
ADHDB
CGR
CUY
CVF
ECM
EIF
NAO
NPM
AEIIB
PMFND
7QP
7TK
7XB
8FK
K9.
LK8
MBDVC
PKEHL
PQEST
PQUKI
PRINS
Q9U
7S9
L.6
7X8
1XC
VOOES
5PM
ID FETCH-LOGICAL-c685t-944347facce0b6912c05c2e45fefeffaff7d9ecc2cabaa39308bc4758de1434e3
IEDL.DBID C6C
ISSN 0954-3007
1476-5640
IngestDate Thu Aug 21 18:22:44 EDT 2025
Fri May 09 12:14:08 EDT 2025
Mon Jul 21 09:49:34 EDT 2025
Fri Jul 11 09:40:29 EDT 2025
Fri Aug 15 19:12:42 EDT 2025
Tue Jun 17 22:06:51 EDT 2025
Fri Jun 13 00:04:09 EDT 2025
Tue Jun 10 21:07:25 EDT 2025
Thu May 22 21:24:33 EDT 2025
Wed Feb 19 01:48:23 EST 2025
Mon Jul 21 09:15:44 EDT 2025
Tue Jul 01 03:15:15 EDT 2025
Thu Apr 24 23:04:00 EDT 2025
Mon Jul 21 06:06:56 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Serum glycosylation
sialylation
glycans
dietary fiber
dietary plant polysaccharides
glycomodifications
Healthy subject
Toxicity
Glycoprotein
Label
Metabolic diseases
Glycosylation
N-glycans
Posology
Feeding
Plant
Diet
Serum
Supplementation
Dietary fiber
Polysaccharide
Food supplement
Dietary plant polysaccharides
Glycomodifications
Sialylation
Language English
License http://www.springer.com/tdm
CC BY 4.0
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c685t-944347facce0b6912c05c2e45fefeffaff7d9ecc2cabaa39308bc4758de1434e3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.nature.com/articles/ejcn.2010.263
PMID 21224866
PQID 864631918
PQPubID 33883
PageCount 9
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3087895
hal_primary_oai_HAL_hal_00608019v1
proquest_miscellaneous_864966385
proquest_miscellaneous_2000600426
proquest_journals_864631918
gale_infotracmisc_A256457680
gale_infotracgeneralonefile_A256457680
gale_infotracacademiconefile_A256457680
gale_healthsolutions_A256457680
pubmed_primary_21224866
pascalfrancis_primary_24108595
crossref_primary_10_1038_ejcn_2010_263
crossref_citationtrail_10_1038_ejcn_2010_263
springer_journals_10_1038_ejcn_2010_263
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2011-05-01
PublicationDateYYYYMMDD 2011-05-01
PublicationDate_xml – month: 05
  year: 2011
  text: 2011-05-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: Basingstoke
– name: England
PublicationTitle European journal of clinical nutrition
PublicationTitleAbbrev Eur J Clin Nutr
PublicationTitleAlternate Eur J Clin Nutr
PublicationYear 2011
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Tuohy, Gougoulias, Shen, Walton, Fava, Ramnani (CR42) 2009; 15
Ma, Hebert, Li, Bertone-Johnson, Olendzki, Pagoto (CR30) 2008; 24
Weickert, Pfeiffer (CR47) 2008; 138
Rideout, Harding, Jones, Fan (CR35) 2008; 4
Hua, Hsu, Chao, Chen, Yang, Hsu (CR21) 2007; 212
Benyacoub, Rochat, Saudan, Rochat, Antille, Cherbut (CR4) 2008; 138
Chassard, Goumy, Leclerc, Del′homme, Bernalier-Donadille (CR11) 2007; 61
Lefkowitz, Stuart, Gnade, Roberts, Lefkowitz (CR26) 2000; 22
Bork, Horstkorte, Weidemann (CR7) 2009; 98
Kim, Joo (CR24) 2008; 115
Schiffrin, Morley, Donnet-Hughes, Guigoz (CR38) 2010; 690
Chan, Chan, Sze (CR10) 2009; 2
Trinchero, Ponce, Cordoba, Flores, Pampuro, Stortz (CR41) 2009; 23
Koetzner, Grover, Boulet, Jacoby (CR25) 2010; 55
van den Broek, Hinz, Beldman, Vincken, Voragen (CR43) 2008; 52
Estruch, Martinez-Gonzalez, Corella, Basora-Gallisa, Ruiz-Gutierrez, Covas (CR17) 2009; 63
Courtois (CR13) 2009; 12
van den Heuvel, Muijs, Brouns, Hendriks (CR44) 2009; 29
Vetvicka, Thornton, Ross (CR45) 1996; 98
Burrows, Assundani, Celis, Tufaro, Tanaka, Bradley (CR9) 2009; 9
Mizuno, Nishitani, Hashimoto, Kanazawa (CR32) 2009; 73
Schauer (CR36) 2009; 19
Alavi, Axford (CR1) 2008; 47
Graff, Kimmel, Freedman, Schepetkin, Holderness, Quinn (CR18) 2009; 9
Liu, Gunn, Hansen, Yan (CR28) 2009; 4
Biol-N′garagba, Louisot (CR5) 2003; 85
Vos, M′Rabet, Stahl, Boehm, Garssen (CR46) 2007; 27
Macfarlane, Steed, Macfarlane (CR31) 2008; 104
Lomax, Calder (CR29) 2009; 101
Schepetkin, Quinn (CR37) 2006; 6
Gunning, Bongaerts, Morris (CR19) 2009; 23
Bruzzese, Volpicelli, Squeglia, Bruzzese, Salvini, Bisceglia (CR8) 2009; 28
Cumashi, Ushakova, Preobrazhenskaya, D′Incecco, Piccoli, Totani (CR14) 2007; 17
de Vrese, Schrezenmeir (CR16) 2008; 111
Ho, Yeung, Chiu, Tang, Lin, Man (CR20) 2007; 301
Yoshino, Tabata, Hazama, Iizuka, Yamamoto, Hirayama (CR48) 2000; 20
Chen, Huang (CR12) 2009; 3
Jettanacheawchankit, Sasithanasate, Sangvanich, Banlunara, Thunyakitpisal (CR23) 2009; 109
Paur, Austenaa, Blomhoff (CR33) 2008; 46
Possemiers, Grootaert, Vermeiren, Gross, Marzorati, Verstraete (CR34) 2009; 15
Dalmo, Bogwald (CR15) 2008; 25
Anthony, Nimmerjahn, Ashline, Reinhold, Paulson, Ravetch (CR2) 2008; 320
Leung, Liu, Koon, Fung (CR27) 2006; 105
Sinnott, Ramberg, Kirchner, Oubre, Duncan, Boyd (CR39) 2007; 2
Stancil, Hicks (CR40) 2009; 108
Bo, Durazzo, Guidi, Carello, Sacerdote, Silli (CR6) 2006; 84
Jacobs, Gaudier, van Duynhoven, Vaughan (CR22) 2009; 10
Arasaradnam, Pharaoh, Williams, Nwokolo, Bardhan, Kumar (CR3) 2009; 73
MH Kim (BFejcn2010263_CR24) 2008; 115
AR Lomax (BFejcn2010263_CR29) 2009; 101
S Possemiers (BFejcn2010263_CR34) 2009; 15
R Schauer (BFejcn2010263_CR36) 2009; 19
K Bork (BFejcn2010263_CR7) 2009; 98
J Trinchero (BFejcn2010263_CR41) 2009; 23
AP Vos (BFejcn2010263_CR46) 2007; 27
A Alavi (BFejcn2010263_CR1) 2008; 47
J Chen (BFejcn2010263_CR12) 2009; 3
V Vetvicka (BFejcn2010263_CR45) 1996; 98
RM Anthony (BFejcn2010263_CR2) 2008; 320
AP Gunning (BFejcn2010263_CR19) 2009; 23
S Jettanacheawchankit (BFejcn2010263_CR23) 2009; 109
GT Macfarlane (BFejcn2010263_CR31) 2008; 104
TC Rideout (BFejcn2010263_CR35) 2008; 4
J Benyacoub (BFejcn2010263_CR4) 2008; 138
GC Chan (BFejcn2010263_CR10) 2009; 2
JC Graff (BFejcn2010263_CR18) 2009; 9
L Koetzner (BFejcn2010263_CR25) 2010; 55
J Courtois (BFejcn2010263_CR13) 2009; 12
DM Jacobs (BFejcn2010263_CR22) 2009; 10
DL Lefkowitz (BFejcn2010263_CR26) 2000; 22
M Mizuno (BFejcn2010263_CR32) 2009; 73
S Yoshino (BFejcn2010263_CR48) 2000; 20
IA Schepetkin (BFejcn2010263_CR37) 2006; 6
MY Leung (BFejcn2010263_CR27) 2006; 105
J Liu (BFejcn2010263_CR28) 2009; 4
KM Tuohy (BFejcn2010263_CR42) 2009; 15
A Cumashi (BFejcn2010263_CR14) 2007; 17
EG van den Heuvel (BFejcn2010263_CR44) 2009; 29
YW Ho (BFejcn2010263_CR20) 2007; 301
MO Weickert (BFejcn2010263_CR47) 2008; 138
RA Dalmo (BFejcn2010263_CR15) 2008; 25
E Bruzzese (BFejcn2010263_CR8) 2009; 28
M Burrows (BFejcn2010263_CR9) 2009; 9
S Bo (BFejcn2010263_CR6) 2006; 84
C Chassard (BFejcn2010263_CR11) 2007; 61
Y Ma (BFejcn2010263_CR30) 2008; 24
AN Stancil (BFejcn2010263_CR40) 2009; 108
MC Biol-N′garagba (BFejcn2010263_CR5) 2003; 85
R Estruch (BFejcn2010263_CR17) 2009; 63
I Paur (BFejcn2010263_CR33) 2008; 46
M de Vrese (BFejcn2010263_CR16) 2008; 111
RA Sinnott (BFejcn2010263_CR39) 2007; 2
LA van den Broek (BFejcn2010263_CR43) 2008; 52
EJ Schiffrin (BFejcn2010263_CR38) 2010; 690
RP Arasaradnam (BFejcn2010263_CR3) 2009; 73
KF Hua (BFejcn2010263_CR21) 2007; 212
18215222 - J Appl Microbiol. 2008 Feb;104(2):305-44
19372635 - J Pharmacol Sci. 2009 Apr;109(4):525-31
11205205 - Anticancer Res. 2000 Nov-Dec;20(6C):4707-11
19289389 - J Epidemiol Community Health. 2009 Jul;63(7):582-8
18562168 - Nutrition. 2008 Oct;24(10):941-9
18814803 - Br J Nutr. 2009 Mar;101(5):633-58
19666034 - Mutat Res. 2010 Aug 7;690(1-2):50-6
18420934 - Science. 2008 Apr 18;320(5874):373-6
17093158 - Am J Clin Nutr. 2006 Nov;84(5):1062-9
21291810 - J Clin Lipidol. 2009 May-Jun;3(3):154-8
18077003 - Immunol Lett. 2008 Jan 29;115(2):138-43
17391327 - FEMS Microbiol Ecol. 2007 Jul;61(1):121-31
19519533 - Recent Pat Anticancer Drug Discov. 2009 Jun;4(2):101-9
19473773 - Med Hypotheses. 2009 Nov;73(5):753-6
19425467 - Percept Mot Skills. 2009 Feb;108(1):259-70
19199295 - J Pharm Sci. 2009 Oct;98(10):3499-508
12770772 - Biochimie. 2003 Mar-Apr;85(3-4):331-52
17474083 - J Cell Physiol. 2007 Aug;212(2):537-50
17296677 - Glycobiology. 2007 May;17(5):541-52
19231042 - Clin Nutr. 2009 Apr;28(2):156-61
18040988 - Mol Nutr Food Res. 2008 Jan;52(1):146-63
16554097 - Immunol Lett. 2006 Jun 15;105(2):101-14
16428067 - Int Immunopharmacol. 2006 Mar;6(3):317-33
19515245 - J Hematol Oncol. 2009;2:25
19809164 - Biosci Biotechnol Biochem. 2009 Oct;73(10):2324-5
19671448 - Int Immunopharmacol. 2009 Oct;9(11):1313-22
19183750 - Vasc Health Risk Manag. 2008;4(5):1023-33
19519443 - Curr Pharm Des. 2009;15(18):2051-65
18375404 - Rheumatology (Oxford). 2008 Jun;47(6):760-70
18832596 - FASEB J. 2009 Feb;23(2):415-24
10689103 - Int J Immunopharmacol. 2000 Apr;22(4):299-308
19149512 - Curr Drug Metab. 2009 Jan;10(1):41-54
19948039 - BMC Complement Altern Med. 2009;9:49
18287346 - J Nutr. 2008 Mar;138(3):439-42
17980947 - Food Chem Toxicol. 2008 Apr;46(4):1288-97
19107862 - Phytother Res. 2009 May;23(5):707-12
19410973 - Nutr Res. 2009 Apr;29(4):229-37
18156414 - J Nutr. 2008 Jan;138(1):123-9
18461293 - Adv Biochem Eng Biotechnol. 2008;111:1-66
17219061 - Mol Cell Biochem. 2007 Jul;301(1-2):173-9
19513840 - Dig Dis Sci. 2010 May;55(5):1278-85
8690804 - J Clin Invest. 1996 Jul 1;98(1):50-61
18606550 - Fish Shellfish Immunol. 2008 Oct;25(4):384-96
19442166 - Curr Pharm Des. 2009;15(13):1415-27
19699080 - Curr Opin Struct Biol. 2009 Oct;19(5):507-14
17725499 - Crit Rev Immunol. 2007;27(2):97-140
19467920 - Curr Opin Microbiol. 2009 Jun;12(3):261-73
References_xml – volume: 84
  start-page: 1062
  year: 2006
  end-page: 1069
  ident: CR6
  article-title: Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn/84.5.1062
– volume: 104
  start-page: 305
  year: 2008
  end-page: 344
  ident: CR31
  article-title: Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
  publication-title: J Appl Microbiol
– volume: 3
  start-page: 154
  year: 2009
  end-page: 158
  ident: CR12
  article-title: The effects of diets enriched in beta-glucans on blood lipoprotein concentrations
  publication-title: J Clin Lipidol
  doi: 10.1016/j.jacl.2009.04.054
– volume: 2
  start-page: 97
  year: 2007
  end-page: 104
  ident: CR39
  article-title: Utilization of arabinogalactan, aloe vera gel polysaccharides, and a mixed saccharide dietary supplement by human colonic bacteria
  publication-title: Int J Probiotics Prebiotics
– volume: 15
  start-page: 2051
  year: 2009
  end-page: 2065
  ident: CR34
  article-title: The intestinal environment in health and disease - recent insights on the potential of intestinal bacteria to influence human health
  publication-title: Curr Pharm Des
  doi: 10.2174/138161209788489159
– volume: 29
  start-page: 229
  year: 2009
  end-page: 237
  ident: CR44
  article-title: Short-chain fructo-oligosaccharides improve magnesium absorption in adolescent girls with a low calcium intake
  publication-title: Nutr Res
  doi: 10.1016/j.nutres.2009.03.005
– volume: 22
  start-page: 299
  year: 2000
  end-page: 308
  ident: CR26
  article-title: Effects of a glyconutrient on macrophage functions
  publication-title: Int J Immunopharmacol
  doi: 10.1016/S0192-0561(99)00085-5
– volume: 19
  start-page: 507
  year: 2009
  end-page: 514
  ident: CR36
  article-title: Sialic acids as regulators of molecular and cellular interactions
  publication-title: Curr Opin Struct Biol
  doi: 10.1016/j.sbi.2009.06.003
– volume: 98
  start-page: 3499
  year: 2009
  end-page: 3508
  ident: CR7
  article-title: Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway
  publication-title: J Pharm Sci
  doi: 10.1002/jps.21684
– volume: 98
  start-page: 50
  year: 1996
  end-page: 61
  ident: CR45
  article-title: Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells
  publication-title: J Clin Invest
  doi: 10.1172/JCI118777
– volume: 109
  start-page: 525
  year: 2009
  end-page: 531
  ident: CR23
  article-title: Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing
  publication-title: J Pharmacol Sci
  doi: 10.1254/jphs.08204FP
– volume: 27
  start-page: 97
  year: 2007
  end-page: 140
  ident: CR46
  article-title: Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates
  publication-title: Crit Rev Immunol
  doi: 10.1615/CritRevImmunol.v27.i2.10
– volume: 101
  start-page: 633
  year: 2009
  end-page: 658
  ident: CR29
  article-title: Prebiotics, immune function, infection and inflammation: a review of the evidence
  publication-title: Br J Nutr
  doi: 10.1017/S0007114508055608
– volume: 6
  start-page: 317
  year: 2006
  end-page: 333
  ident: CR37
  article-title: Botanical polysaccharides: macrophage immunomodulation and therapeutic potential
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2005.10.005
– volume: 55
  start-page: 1278
  year: 2010
  end-page: 1285
  ident: CR25
  article-title: Plant-derived polysaccharide supplements inhibit dextran sulfate sodium-induced colitis in the rat
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-009-0848-7
– volume: 9
  start-page: 1313
  year: 2009
  end-page: 1322
  ident: CR18
  article-title: Polysaccharides derived from Yamoa (Funtumia elastica) prime gammadelta T cells and enhance innate immune responses
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2009.07.015
– volume: 4
  start-page: 1023
  year: 2008
  end-page: 1033
  ident: CR35
  article-title: Guar gum and similar soluble fibers in the regulation of cholesterol metabolism: current understandings and future research priorities
  publication-title: Vasc Health Risk Manag
  doi: 10.2147/VHRM.S3512
– volume: 105
  start-page: 101
  year: 2006
  end-page: 114
  ident: CR27
  article-title: Polysaccharide biological response modifiers
  publication-title: Immunol Lett
  doi: 10.1016/j.imlet.2006.01.009
– volume: 61
  start-page: 121
  year: 2007
  end-page: 131
  ident: CR11
  article-title: Characterization of the xylan-degrading microbial community from human faeces
  publication-title: FEMS Microbiol Ecol
  doi: 10.1111/j.1574-6941.2007.00314.x
– volume: 24
  start-page: 941
  year: 2008
  end-page: 949
  ident: CR30
  article-title: Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study
  publication-title: Nutrition
  doi: 10.1016/j.nut.2008.04.005
– volume: 12
  start-page: 261
  year: 2009
  end-page: 273
  ident: CR13
  article-title: Oligosaccharides from land plants and algae: production and applications in therapeutics and biotechnology
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2009.04.007
– volume: 23
  start-page: 707
  year: 2009
  end-page: 712
  ident: CR41
  article-title: Antiretroviral activity of fucoidans extracted from the brown seaweed Adenocystis utricularis
  publication-title: Phytother Res
  doi: 10.1002/ptr.2723
– volume: 108
  start-page: 259
  year: 2009
  end-page: 270
  ident: CR40
  article-title: Glyconutrients and perception, cognition, and memory
  publication-title: Percept Mot Skills
  doi: 10.2466/pms.108.1.259-270
– volume: 47
  start-page: 760
  year: 2008
  end-page: 770
  ident: CR1
  article-title: Sweet and sour: the impact of sugars on disease
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ken081
– volume: 73
  start-page: 2324
  year: 2009
  end-page: 2325
  ident: CR32
  article-title: Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in gut inflammation
  publication-title: Biosci Biotechnol Biochem
  doi: 10.1271/bbb.90326
– volume: 138
  start-page: 123
  year: 2008
  end-page: 129
  ident: CR4
  article-title: Feeding a diet containing a fructooligosaccharide mix can enhance Salmonella vaccine efficacy in mice
  publication-title: J Nutr
  doi: 10.1093/jn/138.1.123
– volume: 10
  start-page: 41
  year: 2009
  end-page: 54
  ident: CR22
  article-title: Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics
  publication-title: Curr Drug Metab
  doi: 10.2174/138920009787048383
– volume: 63
  start-page: 582
  year: 2009
  end-page: 588
  ident: CR17
  article-title: Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
  publication-title: J Epidemiol Community Health
  doi: 10.1136/jech.2008.082214
– volume: 25
  start-page: 384
  year: 2008
  end-page: 396
  ident: CR15
  article-title: Beta-glucans as conductors of immune symphonies
  publication-title: Fish Shellfish Immunol
  doi: 10.1016/j.fsi.2008.04.008
– volume: 138
  start-page: 439
  year: 2008
  end-page: 442
  ident: CR47
  article-title: Metabolic effects of dietary fiber consumption and prevention of diabetes
  publication-title: J Nutr
  doi: 10.1093/jn/138.3.439
– volume: 15
  start-page: 1415
  year: 2009
  end-page: 1427
  ident: CR42
  article-title: Studying the human gut microbiota in the trans-omics era—focus on metagenomics and metabonomics
  publication-title: Curr Pharm Des
  doi: 10.2174/138161209788168182
– volume: 115
  start-page: 138
  year: 2008
  end-page: 143
  ident: CR24
  article-title: Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells
  publication-title: Immunol Lett
  doi: 10.1016/j.imlet.2007.10.016
– volume: 52
  start-page: 146
  year: 2008
  end-page: 163
  ident: CR43
  article-title: Bifidobacterium carbohydrases-their role in breakdown and synthesis of (potential) prebiotics
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.200700121
– volume: 17
  start-page: 541
  year: 2007
  end-page: 552
  ident: CR14
  article-title: A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwm014
– volume: 23
  start-page: 415
  year: 2009
  end-page: 424
  ident: CR19
  article-title: Recognition of galactan components of pectin by galectin-3
  publication-title: FASEB J
  doi: 10.1096/fj.08-106617
– volume: 4
  start-page: 101
  year: 2009
  end-page: 109
  ident: CR28
  article-title: Yeast-derived beta-glucan in combination with anti-tumor monoclonal antibody therapy in cancer
  publication-title: Recent Pat Anticancer Drug Discov
  doi: 10.2174/157489209788452858
– volume: 85
  start-page: 331
  year: 2003
  end-page: 352
  ident: CR5
  article-title: Regulation of the intestinal glycoprotein glycosylation during postnatal development: role of hormonal and nutritional factors
  publication-title: Biochimie
  doi: 10.1016/S0300-9084(03)00039-7
– volume: 320
  start-page: 373
  year: 2008
  end-page: 376
  ident: CR2
  article-title: Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
  publication-title: Science
  doi: 10.1126/science.1154315
– volume: 301
  start-page: 173
  year: 2007
  end-page: 179
  ident: CR20
  article-title: Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-006-9409-y
– volume: 690
  start-page: 50
  year: 2010
  end-page: 56
  ident: CR38
  article-title: The inflammatory status of the elderly: the intestinal contribution
  publication-title: Mutat Res
  doi: 10.1016/j.mrfmmm.2009.07.011
– volume: 111
  start-page: 1
  year: 2008
  end-page: 66
  ident: CR16
  article-title: Probiotics, prebiotics, and synbiotics
  publication-title: Adv Biochem Eng Biotechnol
– volume: 9
  start-page: 49
  year: 2009
  ident: CR9
  article-title: Oral administration of PPC enhances antigen-specific CD8+ T cell responses while reducing IgE levels in sensitized mice
  publication-title: BMC Complement Altern Med
  doi: 10.1186/1472-6882-9-49
– volume: 2
  start-page: 25
  year: 2009
  ident: CR10
  article-title: The effects of beta-glucan on human immune and cancer cells
  publication-title: J Hematol Oncol
  doi: 10.1186/1756-8722-2-25
– volume: 46
  start-page: 1288
  year: 2008
  end-page: 1297
  ident: CR33
  article-title: Extracts of dietary plants are efficient modulators of nuclear factor kappa B
  publication-title: Food Chem Toxicol
  doi: 10.1016/j.fct.2007.09.103
– volume: 73
  start-page: 753
  year: 2009
  end-page: 756
  ident: CR3
  article-title: Colonic fermentation—more than meets the nose
  publication-title: Med Hypotheses
  doi: 10.1016/j.mehy.2009.04.027
– volume: 28
  start-page: 156
  year: 2009
  end-page: 161
  ident: CR8
  article-title: A formula containing galacto- and fructo-oligosaccharides prevents intestinal and extra-intestinal infections: an observational study
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2009.01.008
– volume: 212
  start-page: 537
  year: 2007
  end-page: 550
  ident: CR21
  article-title: Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.21050
– volume: 20
  start-page: 4707
  year: 2000
  end-page: 4711
  ident: CR48
  article-title: Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers
  publication-title: Anticancer Res
– volume: 12
  start-page: 261
  year: 2009
  ident: BFejcn2010263_CR13
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2009.04.007
– volume: 109
  start-page: 525
  year: 2009
  ident: BFejcn2010263_CR23
  publication-title: J Pharmacol Sci
  doi: 10.1254/jphs.08204FP
– volume: 4
  start-page: 1023
  year: 2008
  ident: BFejcn2010263_CR35
  publication-title: Vasc Health Risk Manag
  doi: 10.2147/VHRM.S3512
– volume: 9
  start-page: 49
  year: 2009
  ident: BFejcn2010263_CR9
  publication-title: BMC Complement Altern Med
  doi: 10.1186/1472-6882-9-49
– volume: 25
  start-page: 384
  year: 2008
  ident: BFejcn2010263_CR15
  publication-title: Fish Shellfish Immunol
  doi: 10.1016/j.fsi.2008.04.008
– volume: 47
  start-page: 760
  year: 2008
  ident: BFejcn2010263_CR1
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/ken081
– volume: 15
  start-page: 1415
  year: 2009
  ident: BFejcn2010263_CR42
  publication-title: Curr Pharm Des
  doi: 10.2174/138161209788168182
– volume: 84
  start-page: 1062
  year: 2006
  ident: BFejcn2010263_CR6
  publication-title: Am J Clin Nutr
  doi: 10.1093/ajcn/84.5.1062
– volume: 24
  start-page: 941
  year: 2008
  ident: BFejcn2010263_CR30
  publication-title: Nutrition
  doi: 10.1016/j.nut.2008.04.005
– volume: 138
  start-page: 123
  year: 2008
  ident: BFejcn2010263_CR4
  publication-title: J Nutr
  doi: 10.1093/jn/138.1.123
– volume: 85
  start-page: 331
  year: 2003
  ident: BFejcn2010263_CR5
  publication-title: Biochimie
  doi: 10.1016/S0300-9084(03)00039-7
– volume: 10
  start-page: 41
  year: 2009
  ident: BFejcn2010263_CR22
  publication-title: Curr Drug Metab
  doi: 10.2174/138920009787048383
– volume: 9
  start-page: 1313
  year: 2009
  ident: BFejcn2010263_CR18
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2009.07.015
– volume: 115
  start-page: 138
  year: 2008
  ident: BFejcn2010263_CR24
  publication-title: Immunol Lett
  doi: 10.1016/j.imlet.2007.10.016
– volume: 27
  start-page: 97
  year: 2007
  ident: BFejcn2010263_CR46
  publication-title: Crit Rev Immunol
  doi: 10.1615/CritRevImmunol.v27.i2.10
– volume: 138
  start-page: 439
  year: 2008
  ident: BFejcn2010263_CR47
  publication-title: J Nutr
  doi: 10.1093/jn/138.3.439
– volume: 19
  start-page: 507
  year: 2009
  ident: BFejcn2010263_CR36
  publication-title: Curr Opin Struct Biol
  doi: 10.1016/j.sbi.2009.06.003
– volume: 212
  start-page: 537
  year: 2007
  ident: BFejcn2010263_CR21
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.21050
– volume: 104
  start-page: 305
  year: 2008
  ident: BFejcn2010263_CR31
  publication-title: J Appl Microbiol
– volume: 52
  start-page: 146
  year: 2008
  ident: BFejcn2010263_CR43
  publication-title: Mol Nutr Food Res
  doi: 10.1002/mnfr.200700121
– volume: 29
  start-page: 229
  year: 2009
  ident: BFejcn2010263_CR44
  publication-title: Nutr Res
  doi: 10.1016/j.nutres.2009.03.005
– volume: 63
  start-page: 582
  year: 2009
  ident: BFejcn2010263_CR17
  publication-title: J Epidemiol Community Health
  doi: 10.1136/jech.2008.082214
– volume: 98
  start-page: 50
  year: 1996
  ident: BFejcn2010263_CR45
  publication-title: J Clin Invest
  doi: 10.1172/JCI118777
– volume: 3
  start-page: 154
  year: 2009
  ident: BFejcn2010263_CR12
  publication-title: J Clin Lipidol
  doi: 10.1016/j.jacl.2009.04.054
– volume: 23
  start-page: 415
  year: 2009
  ident: BFejcn2010263_CR19
  publication-title: FASEB J
  doi: 10.1096/fj.08-106617
– volume: 61
  start-page: 121
  year: 2007
  ident: BFejcn2010263_CR11
  publication-title: FEMS Microbiol Ecol
  doi: 10.1111/j.1574-6941.2007.00314.x
– volume: 15
  start-page: 2051
  year: 2009
  ident: BFejcn2010263_CR34
  publication-title: Curr Pharm Des
  doi: 10.2174/138161209788489159
– volume: 6
  start-page: 317
  year: 2006
  ident: BFejcn2010263_CR37
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2005.10.005
– volume: 23
  start-page: 707
  year: 2009
  ident: BFejcn2010263_CR41
  publication-title: Phytother Res
  doi: 10.1002/ptr.2723
– volume: 4
  start-page: 101
  year: 2009
  ident: BFejcn2010263_CR28
  publication-title: Recent Pat Anticancer Drug Discov
  doi: 10.2174/157489209788452858
– volume: 111
  start-page: 1
  year: 2008
  ident: BFejcn2010263_CR16
  publication-title: Adv Biochem Eng Biotechnol
– volume: 108
  start-page: 259
  year: 2009
  ident: BFejcn2010263_CR40
  publication-title: Percept Mot Skills
  doi: 10.2466/pms.108.1.259-270
– volume: 301
  start-page: 173
  year: 2007
  ident: BFejcn2010263_CR20
  publication-title: Mol Cell Biochem
  doi: 10.1007/s11010-006-9409-y
– volume: 55
  start-page: 1278
  year: 2010
  ident: BFejcn2010263_CR25
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-009-0848-7
– volume: 17
  start-page: 541
  year: 2007
  ident: BFejcn2010263_CR14
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwm014
– volume: 73
  start-page: 2324
  year: 2009
  ident: BFejcn2010263_CR32
  publication-title: Biosci Biotechnol Biochem
  doi: 10.1271/bbb.90326
– volume: 20
  start-page: 4707
  year: 2000
  ident: BFejcn2010263_CR48
  publication-title: Anticancer Res
– volume: 690
  start-page: 50
  year: 2010
  ident: BFejcn2010263_CR38
  publication-title: Mutat Res
  doi: 10.1016/j.mrfmmm.2009.07.011
– volume: 98
  start-page: 3499
  year: 2009
  ident: BFejcn2010263_CR7
  publication-title: J Pharm Sci
  doi: 10.1002/jps.21684
– volume: 28
  start-page: 156
  year: 2009
  ident: BFejcn2010263_CR8
  publication-title: Clin Nutr
  doi: 10.1016/j.clnu.2009.01.008
– volume: 22
  start-page: 299
  year: 2000
  ident: BFejcn2010263_CR26
  publication-title: Int J Immunopharmacol
  doi: 10.1016/S0192-0561(99)00085-5
– volume: 2
  start-page: 25
  year: 2009
  ident: BFejcn2010263_CR10
  publication-title: J Hematol Oncol
  doi: 10.1186/1756-8722-2-25
– volume: 46
  start-page: 1288
  year: 2008
  ident: BFejcn2010263_CR33
  publication-title: Food Chem Toxicol
  doi: 10.1016/j.fct.2007.09.103
– volume: 73
  start-page: 753
  year: 2009
  ident: BFejcn2010263_CR3
  publication-title: Med Hypotheses
  doi: 10.1016/j.mehy.2009.04.027
– volume: 101
  start-page: 633
  year: 2009
  ident: BFejcn2010263_CR29
  publication-title: Br J Nutr
  doi: 10.1017/S0007114508055608
– volume: 2
  start-page: 97
  year: 2007
  ident: BFejcn2010263_CR39
  publication-title: Int J Probiotics Prebiotics
– volume: 320
  start-page: 373
  year: 2008
  ident: BFejcn2010263_CR2
  publication-title: Science
  doi: 10.1126/science.1154315
– volume: 105
  start-page: 101
  year: 2006
  ident: BFejcn2010263_CR27
  publication-title: Immunol Lett
  doi: 10.1016/j.imlet.2006.01.009
– reference: 17296677 - Glycobiology. 2007 May;17(5):541-52
– reference: 19671448 - Int Immunopharmacol. 2009 Oct;9(11):1313-22
– reference: 19231042 - Clin Nutr. 2009 Apr;28(2):156-61
– reference: 19410973 - Nutr Res. 2009 Apr;29(4):229-37
– reference: 19372635 - J Pharmacol Sci. 2009 Apr;109(4):525-31
– reference: 17093158 - Am J Clin Nutr. 2006 Nov;84(5):1062-9
– reference: 19199295 - J Pharm Sci. 2009 Oct;98(10):3499-508
– reference: 17219061 - Mol Cell Biochem. 2007 Jul;301(1-2):173-9
– reference: 17980947 - Food Chem Toxicol. 2008 Apr;46(4):1288-97
– reference: 19183750 - Vasc Health Risk Manag. 2008;4(5):1023-33
– reference: 18814803 - Br J Nutr. 2009 Mar;101(5):633-58
– reference: 18040988 - Mol Nutr Food Res. 2008 Jan;52(1):146-63
– reference: 19948039 - BMC Complement Altern Med. 2009;9:49
– reference: 8690804 - J Clin Invest. 1996 Jul 1;98(1):50-61
– reference: 17474083 - J Cell Physiol. 2007 Aug;212(2):537-50
– reference: 19442166 - Curr Pharm Des. 2009;15(13):1415-27
– reference: 16428067 - Int Immunopharmacol. 2006 Mar;6(3):317-33
– reference: 19809164 - Biosci Biotechnol Biochem. 2009 Oct;73(10):2324-5
– reference: 11205205 - Anticancer Res. 2000 Nov-Dec;20(6C):4707-11
– reference: 19699080 - Curr Opin Struct Biol. 2009 Oct;19(5):507-14
– reference: 18156414 - J Nutr. 2008 Jan;138(1):123-9
– reference: 19467920 - Curr Opin Microbiol. 2009 Jun;12(3):261-73
– reference: 19425467 - Percept Mot Skills. 2009 Feb;108(1):259-70
– reference: 18461293 - Adv Biochem Eng Biotechnol. 2008;111:1-66
– reference: 16554097 - Immunol Lett. 2006 Jun 15;105(2):101-14
– reference: 18562168 - Nutrition. 2008 Oct;24(10):941-9
– reference: 10689103 - Int J Immunopharmacol. 2000 Apr;22(4):299-308
– reference: 18606550 - Fish Shellfish Immunol. 2008 Oct;25(4):384-96
– reference: 19107862 - Phytother Res. 2009 May;23(5):707-12
– reference: 17725499 - Crit Rev Immunol. 2007;27(2):97-140
– reference: 19473773 - Med Hypotheses. 2009 Nov;73(5):753-6
– reference: 21291810 - J Clin Lipidol. 2009 May-Jun;3(3):154-8
– reference: 19666034 - Mutat Res. 2010 Aug 7;690(1-2):50-6
– reference: 18375404 - Rheumatology (Oxford). 2008 Jun;47(6):760-70
– reference: 19513840 - Dig Dis Sci. 2010 May;55(5):1278-85
– reference: 19515245 - J Hematol Oncol. 2009;2:25
– reference: 19149512 - Curr Drug Metab. 2009 Jan;10(1):41-54
– reference: 19289389 - J Epidemiol Community Health. 2009 Jul;63(7):582-8
– reference: 17391327 - FEMS Microbiol Ecol. 2007 Jul;61(1):121-31
– reference: 18287346 - J Nutr. 2008 Mar;138(3):439-42
– reference: 18077003 - Immunol Lett. 2008 Jan 29;115(2):138-43
– reference: 18215222 - J Appl Microbiol. 2008 Feb;104(2):305-44
– reference: 19519443 - Curr Pharm Des. 2009;15(18):2051-65
– reference: 18832596 - FASEB J. 2009 Feb;23(2):415-24
– reference: 12770772 - Biochimie. 2003 Mar-Apr;85(3-4):331-52
– reference: 19519533 - Recent Pat Anticancer Drug Discov. 2009 Jun;4(2):101-9
– reference: 18420934 - Science. 2008 Apr 18;320(5874):373-6
SSID ssj0014772
Score 2.0364
Snippet Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science....
The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science. In-vitro and...
Background: The functional role of dietary carbohydrates in nutrition is one of the most complex and at times controversial areas in nutritional science....
European Journal of Clinical Nutrition (2011) 65, 648-656; doi: 10.1038/ejcn.2010.263; published online 12 January 2011
SourceID pubmedcentral
hal
proquest
gale
pubmed
pascalfrancis
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 648
SubjectTerms 631/45/72/1201
631/92/436
692/700/459/1994
Adult
Biological and medical sciences
Biopolymers
blood proteins
blood serum
Carbohydrates
Clinical Nutrition
dietary carbohydrate
Dietary Carbohydrates - administration & dosage
Dietary fiber
Dietary supplements
Dietary Supplements - adverse effects
dose response
Dose-Response Relationship, Drug
Epidemiology
Feeding. Feeding behavior
Female
Flowers & plants
Fluctuations
Food safety
Fundamental and applied biological sciences. Psychology
Glycoproteins
Glycoproteins - blood
Glycosylation
Health aspects
Humans
immunomodulators
Ingestion
Internal Medicine
Male
Mass spectrometry
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Nutrition research
Original
original-article
Physiological aspects
Pilot Projects
Plants - chemistry
Polysaccharides
Polysaccharides - administration & dosage
Polysaccharides - blood
Public Health
Regression analysis
Saccharides
Safety
Vertebrates: anatomy and physiology, studies on body, several organs or systems
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELfYeEFCCDY-wsY4ENpeiJY0buI8oQqYKgR9YlLfIsd2tk5ZUpZ2Uv42_jnuHDdToEN9iy_-qM-Xu_Pd7xj7YFSoZBwrX0ie-jwaaR-V-twvogKthQIVDk4Jzj9m8fScf5uP5y42p3FhlRuZaAW1rhX5yE9FzGNkl1B8Wv7yqWgUXa66Cho77CEhl1FEVzLv7a2QJ7Z2EyoR5PwPEgexGUTi1FypqovrGsXR4JPkBPPOJcVFPl7KBv-qoqtxsU0J_TeW8q8LVfudOnvKnjgFEyYdRzxjD0y1x_YnFRrX1y0cgw35tL70PeZ9WZgVPnPgoCXMNtj8--z3pAIqreUjm5gSdE1OBbBotLCqwaGEG0AFEhpZmFULstLg4kOgLkCCxu7lTQvLEvfP18jst0bDsi7bRirK91pofJnqilonJdSV7W7mX5Stqpu2i9MDSnpa2y7xvKyvwbZagIlF1cCigi6Zs8WucnIrNc_Z-dnXn5-nvqv04KtYjFd-ynnEkwKHNkEep-FIBWM1MnxcGPwVsigSnSKzjZTMpYzSKBC54mjqaIP6HjfRC7Zb1ZV5xYAbYfJIJyJHChFrGY_HMQ-1RsVXBirw2MfNZmfKwaBTNY4ys9fxkciINzLijQx5w2PHPfmyw_-4j_AtcU7WrbiXG9lkRHg9aNThyCeWgiQHjqikS4DAeRMG14DyeEB50SGQbyM8HBCiaFCD5vfIxv28CUl8Ovme0TPC4UHlJL0NPXY04PKeHHU7i37nsYMN22dOwDVZfxw99q5vpeEpZq8y9brJbBKYtdE9BvfQYDdob0cCB3nZnaO74enOV8T4cjI4YYPlDFuqxaUFSCeUS0ETP9mcxbuJb9281_9d4gF71N0kUJjrIdtd3azNG1RFV_mRFTh_ADB9jX4
  priority: 102
  providerName: ProQuest
Title An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects
URI https://link.springer.com/article/10.1038/ejcn.2010.263
https://www.ncbi.nlm.nih.gov/pubmed/21224866
https://www.proquest.com/docview/864631918
https://www.proquest.com/docview/2000600426
https://www.proquest.com/docview/864966385
https://hal.science/hal-00608019
https://pubmed.ncbi.nlm.nih.gov/PMC3087895
Volume 65
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fa9swEBdrC2NQxpbuj9cuu43RvszUiRVbecyyljDWMMYKfTOyJLcZqR3qpODPti-3O0lJ8dbCCOTBOusk--580t39xNhHo3pKJokKheTDkMd9HaJTn4dFXOBqoUCHg1OB89k0mZzzrxeDC1-sXvu0Sgdpac30Ojvs2PxSpUvE6ifxFtsh1HYS6HEy3gQNeGrPakKngTb7o9RDakaxaN_e-gR5Q7x1RXmQuwtZ46Mp3JkW9zmd_-ZO_hVAtd-l02fsqXcoYeSm8Jw9MmWH7Y1wdtV1A4dgUzzt3nmHBV9mZonXPBjoHKZrLP4Oe3zmo-wdtuv28sCVKO2x36MS6JStECXGzEFXtL8AFpgWlhV4wHAD6EtCLQuzbECWGnyqCFQFSNDIWd40sJjjqww1yv2t0bCo5k0tFZV-zTTeTEeM2v1KqErb3TS8nDeqqhuXsgdU_7SyXaLqrK7BtlqsiVlZw6wEV9fZYFc57TDVL9j56cnP8ST0hz6EKhGDZTjkPOZpgaxNlCfDXl9FA9U3fFAY_BWyKFI9RLnrK5lLGQ_jSOSK46pHG3T9uIlfsu2yKs1rBtwIk8c6FTlSiETLZDBIeE9r9IFlpKKAfVrLQaY8IjodzDHPbGQ-FhmJTUZik6HYBOxwQ75wUCAPEb4jocrcjDcmJBv1CboH13fI-chSkBFBjkr6WggcN8FxtSgPW5SXDoz8PsKDFiFaCdVq_oASvhk3gYpPRt8yukaQPOinDG97Aeu2FGBDjm6eBcIL2P5aIzJv6-pMJDxBQ94TAXu_aSX2lL5XmmpVZ7YezC7XAwYP0GA3uPSOBTJ55VTsjj2Ff0WCN6ct5WtNp91Szq4sVjoBXgoa-NFaTe8Gfu_Le_PflPvsiQswUPbrAdte3qzMW_RQl3mXbaUXKf6Lca_Ldj6fTL__6Fpb9QfSe5X2
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF616QEkhKDlYVraAUF7wapjbxzngFCgrVLaRgi1Um9mvbtuglI71EmRfxS_gD_HzPpRGVJulW_e8T60345nZ2e_YeyNlm0pfF_ageA9m3uustGoj-zYi3G3EKPBwemC88nQH5zxz-ed8yX2q7oLQ2GVlU40ilqlknzku4HPfYRLO_gw_WFT0ig6XK0yaBSoONL5T9yxZe8P93B637ruwf7pp4FdJhWwpR90ZnaPc493YyGldiK_13al05Gu5p1Y4xOLOO6qHo7LlSISwut5ThBJjla10mhacO1hvctshXu4k2mxlY_7wy9f62ML3jXZotBsoeMGp1uSejpesKu_y6SIJHN9r_ETLH8FyyOKxHwwFRlOTlxk1Vhk9v4bvfnXEa75Mx48Yg9Lkxb6BQYfsyWdrLK1foLb-csctsEEmRrv_Sqz9sZ6hu9KOtIJDKtsAGvsdz8BSuZlIzD1BFRKbgww_LcwS6HkJdeAJitkItazHESioIxIgTQGAQqrF1c5TCeIGFvh8rrWCqbpJM9wLkbiaqzwY8pkatyikCamuqF9McllmuVFZCDQNau5qRJX6PwSTKmhtBgnGYwTKK6P5lhVRI6s7Ak7uxMYPGWtJE30cwZcBzryVDeIUCLwlfA7HZ-3lUJTWzjSsdi7arJDWRKvU_6PSWgCALwgJGyEhI0QsWGx7Vp8WjCO3Ca4RcgJixHXmirsu8QQhNtIbHnHSJCuwhalKK9cYL-J9ashud2QvCg4zxcJbjQEURnJRvFrhHHdb-IuH_SPQ3pHzD9oDvWu2xbbbKC8Fkdr0vDtWWy9gn1YqtQsrBWAxV7VpdQ8RQkmOp1nobl2ZrwCFoNbZLAa3OF7ATbyrFhHN83TKXPg48fdxgprDKdZkoxHhpKdeDUD6vhOtRZvOr5w8l78d4hb7N7g9OQ4PD4cHq2z-8U5BgXZbrDW7GquX6IhPIs2S_UD7Ntda7w_gL3Okw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbaIiEkhKDlEVraAUF7Ido8nMceEFpRqpaWFQcq9RYc22kXbZOl2S3KT0P8OWacRxVouVW5xRM_5M-TGXv8DWOvtXSlCENpx4IPbe57ykajPrUzP0NvIUODg9MF58_jcP-YfzoJTpbYr_YuDIVVtjrRKGpVSNojH8QhDxEubjzImqiIL7t772c_bEogRQetbTaNGiGHuvqJ3lv57mAXp_qN5-19_Pph324SDNgyjIO5PeTc51EmpNROGg5dTzqB9DQPMo1PJrIsUkMcoydFKoQ_9J04lRwtbKXRzODax3qX2Z3ID1xaYtFJ5-u5PDJ5o9CAoYMHJ2roPR0_HujvMq9jyrzQ7_0Om5_C8hnFZN6fiRKnKavza1xnAP8bx_nXYa75R-49ZA8a4xZGNRofsSWdr7K1UY6O_XkF22DCTc0-_iqzdid6ju8aYtIpjNu8AGvs9ygHSutlI0T1FFRBGxpgmHBhXkDDUK4BjVcoRabnFYhcQRObAkUGAhRWLy4qmE0RO7bChXapFcyKaVXiTJyJi4nCjymnqdkghSI31Y3t02kli7KqYwSBLlwtTJW4VhfnYEoNucUkL2GSQ32RtMKqUtrSKh-z41sBwRO2khe5fsaA61invoriFCXiUIkwCELuKoVGt3CkY7G37WQnsqFgp0wg08SEAvhxQthICBsJYsNi2534rOYeuUlwi5CT1CPudFYy8ogrCB1KbHnHSJDWwhalaC5fYL-J_6snud2TPK3Zz68T3OgJolqSveJXCOOu38Rivj86SugdcQChYTS8dC222UN5J452pWHes9h6C_ukUa5l0qkCi73sSql5ihfMdbEoE3MBzewPWAxukMFq0Nf3Y2zkab2Orpqn8-Y4xI-j3grrDadfkk_ODDk7MWzG1PGddi1edfzayXv-3yFusbuo55Kjg_HhOrtXH2hQtO0GW5lfLPQLtIjn6abRPcC-3bay-wNJhNFj
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+open-label+dosing+study+to+evaluate+the+safety+and+effects+of+a+dietary+plant-derived+polysaccharide+supplement+on+the+N-glycosylation+status+of+serum+glycoproteins+in+healthy+subjects&rft.jtitle=European+journal+of+clinical+nutrition&rft.au=Alavi%2C+A&rft.au=Fraser%2C+O&rft.au=Tarelli%2C+E&rft.au=Bland%2C+M&rft.date=2011-05-01&rft.pub=Nature+Publishing+Group&rft.issn=0954-3007&rft.eissn=1476-5640&rft.volume=65&rft.issue=5&rft.spage=648&rft.epage=656&rft_id=info:doi/10.1038%2Fejcn.2010.263&rft_id=info%3Apmid%2F21224866&rft.externalDocID=PMC3087895
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0954-3007&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0954-3007&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0954-3007&client=summon