Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy

• Published in: Journal of allergy and clinical immunology Vol. 130; no. 1; pp. 215 - 224.e7
• Main Authors: Swamy, Ravi S., Reshamwala, Neha, Hunter, Tessa, Vissamsetti, Soujanya, Santos, Carah B., Baroody, Fuad M., Hwang, Peter H., Hoyte, Elisabeth G., Garcia, Marco A., Nadeau, Kari C.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.07.2012; Elsevier; Elsevier Limited
• Subjects: Administration, Sublingual; Adult; adults; allergens; Allergens - immunology; Allergies; Allergy and Immunology; Animals; Asthma; Biological and medical sciences; Bronchi - cytology; Bronchi - immunology; Child; Child, Preschool; children; Cytokines - metabolism; Dermatophagoides; Desensitization, Immunologic - methods; DNA methylation; Double-Blind Method; drug therapy; Dust - immunology; dust mites; epigenetics; Epigenomics; Epithelial Cells - immunology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene expression; Humans; hypersensitivity; immunoglobulin E; immunoglobulin G; Immunopathology; immunotherapy; Interleukin-1 - metabolism; loci; Lymphocytes; Male; Mast Cells - immunology; Medical sciences; Mites - immunology; nose; patients; Phleum - immunology; Phleum pratense; placebos; regulatory T cell; Respiratory allergies; Rhinitis, Allergic, Seasonal - immunology; Rhinitis, Allergic, Seasonal - therapy; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; sublingual immunotherapy; T-lymphocytes; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Th2 Cells - immunology; Treatment Outcome; Respiratory allergies; GITR; SLIT; Treg; DM; regulatory T cell; GPS; NDC; epigenetics; TG; Teff; CTLA-4; sublingual immunotherapy; Foxp3; PD-1; Glucocorticoid-induced TNF receptor; Programmed death 1; Forkhead box protein 3; Regulatory T; Timothy grass; Cytotoxic T-lymphocyte antigen 4; Grass pollen season; CD4 + effector T; Dust mite; Nasal disk challenge; Human; Allergy; Immunopathology; Modification; Desensitization; Sublingual administration; Respiratory system; Immunology; T-Lymphocyte; Epigenetics; Regulatory cell

Allergen-specific immunotherapy is the only mode of therapy that has been demonstrated to offer a cure in patients with IgE-mediated respiratory allergies. We sought to demonstrate the safety and efficacy of timothy grass (TG) and dust mite (DM) dual sublingual immunotherapy (SLIT) and to begin to i...