Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells

• Published in: American journal of human genetics Vol. 90; no. 2; pp. 217 - 228
• Main Authors: Forsberg, Lars A., Rasi, Chiara, Razzaghian, Hamid R., Pakalapati, Geeta, Waite, Lindsay, Thilbeault, Krista Stanton, Ronowicz, Anna, Wineinger, Nathan E., Tiwari, Hemant K., Boomsma, Dorret, Westerman, Maxwell P., Harris, Jennifer R., Lyle, Robert, Essand, Magnus, Eriksson, Fredrik, Assimes, Themistocles L., Iribarren, Carlos, Strachan, Eric, O'Hanlon, Terrance P., Rider, Lisa G., Miller, Frederick W., Giedraitis, Vilmantas, Lannfelt, Lars, Ingelsson, Martin, Piotrowski, Arkadiusz, Pedersen, Nancy L., Absher, Devin, Dumanski, Jan P.
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 10.02.2012; Cell Press; Elsevier
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; Biological and medical sciences; Blood Cells - physiology; Cells; Child; Cloning; Cohort Studies; DNA Copy Number Variations - genetics; Female; Fundamental and applied biological sciences. Psychology; General aspects. Genetic counseling; Genetic research; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human; Genomes; Humans; Individuality; Longitudinal Studies; Medical genetics; Medical sciences; Middle Aged; Molecular and cellular biology; Mutation; Mutation - genetics; Myelodysplastic Syndromes - blood; Myelodysplastic Syndromes - genetics; Twins, Monozygotic - genetics; Young Adult; Human; Blood cell; Somatic cell; Genetics; Change; Genome; Age

Structural variations are among the most frequent interindividual genetic differences in the human genome. The frequency and distribution of de novo somatic structural variants in normal cells is, however, poorly explored. Using age-stratified cohorts of 318 monozygotic (MZ) twins and 296 single-bor...