Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination - Leroux-Roels, Geert; Van Belle, Pascale; Vandepapeliere, Pierre; Horsmans, Yves; Janssens, Michel; Carletti, Isabelle; Garçon, Nathalie; Wettendorff, Martine; Van Mechelen, Marcelle (Vaccine, 2015)
Keywords: Adjuvant system; Adjuvants; Adjuvants, Immunologic; Adult; Allergy and Immunology; antibodies; B-lymphocytes; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; blood sampling; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; cell-mediated immunity; Cellular immunity; emulsions; Female; Follow-Up Studies; Hepatitis; Hepatitis B - immunology; Hepatitis B - prevention & control; Hepatitis B Antibodies - blood; Hepatitis B Antibodies - immunology; hepatitis B antigens; Hepatitis B Surface Antigens - immunology; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - adverse effects; Hepatitis B Vaccines - immunology; Hepatitis B virus; HIV; Human immunodeficiency virus; Humans; humoral immunity; Immune response; Immune system; Immunity, Cellular; Immunity, Humoral; Immunologic Memory; interferon-gamma; interleukin-2; Laboratories; lipid A; Lipid A - analogs & derivatives; Lipid A - immunology; Lymphocyte Count; Male; memory; MPL; Peptides; QS-21; Saponins - immunology; Studies; subunit vaccines; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; tumor necrosis factor-alpha; Vaccination; Vaccine; Vaccines; Young Adult; Belgium; IFNγ; TNFα; MPL; Adjuvants; HBsAg; Cellular immunity; Vaccine; Adjuvant system; ELISPOT; PBMC; IL2; GMT; QS-21; AS; HIV; ICS; DTH; 3- O-desacyl-4′-monophosphoryl lipid A; geometric mean antibody titre; interleukin 2; enzyme-linked immunosorbent spot; tumour necrosis factor alpha; peripheral blood mononuclear cells; interferon gamma; hepatitis B surface antigen; intracellular cytokine staining; delayed-type hypersensitivity; Quillaja saponaria Molina fraction 21; human immunodeficiency virus