Peripheral nerve regeneration and intraneural revascularization

• Published in: Neural regeneration research Vol. 14; no. 1; pp. 24 - 33
• Main Authors: Caillaud, Martial, Richard, Laurence, Vallat, Jean-Michel, Desmoulière, Alexis, Billet, Fabrice
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; University of Limoges, Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, Limoges, France%University Hospital of Limoges, Department of Neurology, "Reference Center for Rare Peripheral Neuropathies", Department of Neurology, Limoges, France; Publishing House of Neural Regeneration Research; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Classification; compression; crush; transection; Sunderland′s classification; Wallerian degeneration; angiogenesis; traumatic; glycerol; Diagnosis; Electrophysiology; Injuries; Ischemia; Laboratory animals; Life Sciences; Nervous system; Peripheral nerve diseases; Peripheral neuropathy; Review; traumatic; crush; Wallerian degeneration; angiogenesis; Sunderland's classification; compression; glycerol; transection; Angiogenesis; Compression; Traumatic; Transection; Glycerol; Crush
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.243699

Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. The current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.