Human umbilical cord blood-derived stem cells and brain-derived neurotrophic factor protect injured optic nerve：viscoelasticity characterization

• Published in: Neural regeneration research Vol. 11; no. 4; pp. 652 - 656
• Main Authors: Lv, Xue-man, Liu, Yan, Wu, Fei, Yuan, Yi, Luo, Min
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 01.04.2016; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of 0phthalmology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China%Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China%Department of Gynaecology and 0bstetrics, Second Hospital of Jilin University, Changchun, Jilin Province, China%Department of Pain Management, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Analysis; Brain-derived neurotrophic factor; Laboratory animals; Medical research; nerve regeneration; optic nerve injury; human umbilical cord blood-derived stem cells; brain-derived neurotrophic factors; creep; histomorphology; stress relaxation; viscoelasticity; neural regeneration; Neurotrophins; Optic nerve; Optics; Rabbits; Retina; Stem cells; Umbilical cord; Viscoelasticity; 应力松弛; 弹性特性; 损伤模型; 神经保护; 脐带血干细胞; 脑源性神经营养因子; 蠕变性能; 视神经损伤; China; Japan; neural regeneration; brain-derived neurotrophic factors; viscoelasticity; human umbilical cord blood-derived stem cells; creep; optic nerve injury; nerve regeneration; histomorphology; stress relaxation

The optic nerve is a viscoelastic solid-like biomaterial.Its normal stress relaxation and creep properties enable the nerve to resist constant strain and protect it from injury.We hypothesized that stress relaxation and creep properties of the optic nerve change after injury.Moreover,human brain-der...