A guide to the composition and functions of the extracellular matrix

• Published in: The FEBS journal Vol. 288; no. 24; pp. 6850 - 6912
• Main Authors: Karamanos, Nikos K., Theocharis, Achilleas D., Piperigkou, Zoi, Manou, Dimitra, Passi, Alberto, Skandalis, Spyros S., Vynios, Demitrios H., Orian‐Rousseau, Véronique, Ricard‐Blum, Sylvie, Schmelzer, Christian E.H., Duca, Laurent, Durbeej, Madeleine, Afratis, Nikolaos A., Troeberg, Linda, Franchi, Marco, Masola, Valentina, Onisto, Maurizio
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2021; Wiley
• Subjects: Angiogenesis; Animals; Autophagy; Basic Medicine; Bioaccumulation; CD44 antigen; Cell adhesion; Cell and Molecular Biology; Cell differentiation; Cell migration; Cell proliferation; Cell signaling; Cell surface; Cell survival; Cell- och molekylärbiologi; Collagen; collagens; Composition; Cytology; disease progression; Elastin; Extracellular matrix; Extracellular Matrix - chemistry; Extracellular Matrix - metabolism; Glycoproteins; Glycosaminoglycans; Glycosidases; heparanase; human health; Humans; hyaluronan; Hyaluronic acid; hyaluronidases; immunity; Integrins; laminin; laminins; Life Sciences; Macromolecules; Matrix metalloproteinase; Matrix metalloproteinases; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; metalloproteinases; organogenesis; Phagocytosis; Proteoglycans; tenascins; therapeutics; glycosaminoglycans; proteoglycans; integrins; collagens; tenascins; hyaluronan; laminins; heparanase; hyaluronidases; elastin; matrix metalloproteinases; extracellular matrix

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated knowledge clearly demonstrated over the last decade that ECM plays key regulatory roles since it orchestrates cell signaling, functions, properties...