Evaluation and comparison of the potential of two ferritins as anti-tick vaccines against Haemaphysalis longicornis

• Published in: Parasites & vectors Vol. 7; no. 1; p. 482
• Main Authors: Galay, Remil Linggatong, Miyata, Takeshi, Umemiya-Shirafuji, Rika, Maeda, Hiroki, Kusakisako, Kodai, Tsuji, Naotoshi, Mochizuki, Masami, Fujisaki, Kozo, Tanaka, Tetsuya
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 12.10.2014; BioMed Central Ltd; BioMed Central; BMC
• Subjects: acaricides; Animals; antibodies; Antibodies - blood; Antigen-antibody reactions; Antigens; antiserum; Arachnids; biomarkers; blood serum; body weight; Comparative analysis; Control; cost effectiveness; cross reaction; Disease transmission; Eggs; enzyme-linked immunosorbent assay; Experiments; Female; Ferritin; Ferritins - immunology; Ferritins - metabolism; Haemaphysalis longicornis; hatching; Health aspects; humans; Immunization; Industrial development; Infectious diseases; Iron metabolism; Ixodidae; Ixodidae - metabolism; Laboratories; Larva - immunology; larvae; Lyme disease; Medical research; Methods; midgut; oviposition; Ovum - immunology; Oxidative stress; Prevention; Proteins; Rabbits; Recombinant Proteins; RNA interference; Science; Studies; tick control; tick infestations; Tick Infestations - parasitology; Tick Infestations - prevention & control; Tick-borne diseases; Ticks; Vaccine; vaccines; Vaccines - immunology; Vaccines, Synthetic; Veterinary medicine; Western blotting; Japan

BACKGROUND: Tick control is an essential aspect of controlling the spread of tick-borne diseases affecting humans and animals, but it presently faces several challenges. Development of an anti-tick vaccine is aimed at designing cost-effective and environmentally friendly protection against ticks and...