PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome
PDZ domains have long been thought to cluster into discrete functional classes defined by their peptide-binding preferences. We used protein microarrays and quantitative fluorescence polarization to characterize the binding selectivity of 157 mouse PDZ domains with respect to 217 genome-encoded pept...
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Published in | Science (American Association for the Advancement of Science) Vol. 317; no. 5836; pp. 364 - 369 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Association for the Advancement of Science
20.07.2007
The American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
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