Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats

• Published in: Neurobiology of aging Vol. 32; no. 5; pp. 864 - 874
• Main Authors: Cekic, Milos, Cutler, Sarah M., VanLandingham, Jacob W., Stein, Donald G.
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.05.2011; Elsevier
• Subjects: 1,25-Dihydroxyvitamin D 3; Aging; Aging - drug effects; Aging - metabolism; Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Brain Injuries - drug therapy; Brain Injuries - metabolism; Cytokines - metabolism; Development. Senescence. Regeneration. Transplantation; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Inflammation; Injuries of the nervous system and the skull. Diseases due to physical agents; Internal Medicine; Male; Medical sciences; Neurology; Progesterone; Progesterone - therapeutic use; Rats; Rats, Inbred F344; Traumas. Diseases due to physical agents; Traumatic brain injury; Vertebrates: nervous system and sense organs; Vitamin D deficiency; Vitamin D Deficiency - drug therapy; Vitamin D Deficiency - metabolism; Vitamin D Deficiency - physiopathology; Aging; Vitamin D deficiency; Inflammation; 1,25-Dihydroxyvitamin D 3; Traumatic brain injury; Progesterone; Senescence; Rat; Steroid hormone; Cholecalciferol(1,25-dihydroxy); Rodentia; Central nervous system; Trauma; Ovarian hormone; Encephalon; Micronutrient; Vertebrata; Mammalia; Vitamin D; Animal; 1,25-Dihydroxyvitamin D; Lesion; Sex steroid hormone

Administration of the neurosteroid progesterone (PROG) has been shown to be beneficial in a number of brain injury models and in two recent clinical trials. Given widespread vitamin D deficiency and increasing traumatic brain injuries (TBIs) in the elderly, we investigated the interaction of vitamin...