Protective effect of ginsenosides Rk3 and Rh4 on cisplatin-induced acute kidney injury in vitro and in vivo

• Published in: Journal of ginseng research Vol. 41; no. 3; pp. 233 - 239
• Main Authors: Baek, Seung-Hoon, Shin, Byong-kyu, Kim, Nam Jae, Chang, Sun-Young, Park, Jeong Hill
• Format: Journal Article
• Language: English
• Published: Korea (South) Elsevier B.V 01.07.2017; 고려인삼학회; Elsevier
• Subjects: acute kidney injury; adverse effects; animal models; antioxidant activity; antioxidant enzymes; blood serum; catalase; cell viability; cisplatin; creatinine; cytotoxicity; drug therapy; edema; enzyme activity; epithelium; ginsenoside Rh4; ginsenoside Rk3; ginsenosides; glutathione-disulfide reductase; heat; histopathology; intraperitoneal injection; kidneys; nephrotoxicity; oxidative toxicity; Panax ginseng; protective effect; reactive oxygen species; renal function; superoxide dismutase; swine; urea nitrogen; 기타의약학; acute kidney injury; ginsenoside Rh4; cisplatin; Panax ginseng; ginsenoside Rk3

Nephrotoxicity is the major side effect in cisplatin chemotherapy. Previously, we reported that the ginsenosides Rk3 and Rh4 reduced cisplatin toxicity on porcine renal proximal epithelial tubular cells (LLC-PK1). Here, we aimed to evaluate the protective effect of ginsenosides Rk3 and Rh4 on kidney...