Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging

• Published in: Nature structural & molecular biology Vol. 23; no. 6; pp. 566 - 573
• Main Authors: Labrie, Viviane, Buske, Orion J, Oh, Edward, Jeremian, Richie, Ptak, Carolyn, Gasiūnas, Giedrius, Maleckas, Almantas, Petereit, Rūta, Žvirbliene, Aida, Adamonis, Kęstutis, Kriukienė, Edita, Koncevičius, Karolis, Gordevičius, Juozas, Nair, Akhil, Zhang, Aiping, Ebrahimi, Sasha, Oh, Gabriel, Šikšnys, Virginijus, Kupčinskas, Limas, Brudno, Michael, Petronis, Arturas
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2016; Nature Publishing Group
• Subjects: 38/77; 45/23; 45/61; 45/90; 49/22; 631/208/176; 631/337/176/1988; 64/60; 96/106; Adult; Age factors in disease; Aged; Aging; Aging (Biology); Analysis; Animals; Biochemistry; Biological Microscopy; Chromosomes - genetics; CRISPR-Cas Systems; Deoxyribonucleic acid; DNA; DNA Methylation; Enzymes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Genetic aspects; Genetic factors; Haplotypes; Health aspects; Human populations; Humans; Jejunum - enzymology; Jejunum - metabolism; Lactase; Lactase - genetics; Lactose Intolerance - enzymology; Lactose Intolerance - genetics; Life Sciences; Mammals; Membrane Biology; Mice; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Phenotypes; Promoter Regions, Genetic; Properties; Protein Structure; RNA, Messenger - genetics; Young Adult

Age-dependent epigenetic changes that are influenced by genetic factors contribute to lactase nonpersistence, which is linked to the inability of adult mammals to digest lactose. The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain hum...