Lactase nonpersistence is directed by DNA-variation-dependent epigenetic aging - Labrie, Viviane; Buske, Orion J; Oh, Edward; Jeremian, Richie; Ptak, Carolyn; Gasiūnas, Giedrius; Maleckas, Almantas; Petereit, Rūta; Žvirbliene, Aida; Adamonis, Kęstutis; Kriukienė, Edita; Koncevičius, Karolis; et al. (Nature structural & molecular biology, 2016)
Keywords: 38/77; 45/23; 45/61; 45/90; 49/22; 631/208/176; 631/337/176/1988; 64/60; 96/106; Adult; Age factors in disease; Aged; Aging; Aging (Biology); Analysis; Animals; Biochemistry; Biological Microscopy; Chromosomes - genetics; CRISPR-Cas Systems; Deoxyribonucleic acid; DNA; DNA Methylation; Enzymes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Genetic aspects; Genetic factors; Haplotypes; Health aspects; Human populations; Humans; Jejunum - enzymology; Jejunum - metabolism; Lactase; Lactase - genetics; Lactose Intolerance - enzymology; Lactose Intolerance - genetics; Life Sciences; Mammals; Membrane Biology; Mice; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Phenotypes; Promoter Regions, Genetic; Properties; Protein Structure; RNA, Messenger - genetics; Young Adult