MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers

• Published in: Journal of allergy and clinical immunology Vol. 129; no. 4; pp. 1064 - 1075.e9
• Main Authors: Lu, Thomas X., Sherrill, Joseph D., Wen, Ting, Plassard, Andrew J., Besse, John A., Abonia, Juan Pablo, Franciosi, James P., Putnam, Philip E., Eby, Michael, Martin, Lisa J., Aronow, Bruce J., Rothenberg, Marc E.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2012; Elsevier; Elsevier Limited
• Subjects: adaptive immunity; Allergy and Immunology; Bioinformatics; Biological and medical sciences; biomarkers; Biopsy; Cell Count; Cluster Analysis; Disease; DNA methylation; Eosinophilia; Eosinophilic esophagitis; Eosinophilic Esophagitis - genetics; Eosinophilic Esophagitis - immunology; Eosinophils - immunology; Eosinophils - metabolism; esophageal diseases; Esophagitis; Esophagus; Esophagus - pathology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Gene expression; Gene Expression Profiling; gene expression regulation; Gene Expression Regulation - drug effects; Gene Regulatory Networks; Genetic Markers; glucocorticoid; Glucocorticoids; Glucocorticoids - pharmacology; Humans; Immunity; Immunopathology; Leukocytes (eosinophilic); Medical sciences; messenger RNA; microRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; miRNA; Other diseases. Semiology; patients; Polarization; Remission; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; transcriptome; Translation; microRNA; miRNA; glucocorticoid; EoE; Eosinophilic esophagitis; biomarkers; Human; Immunopathology; RNA interference; Esophageal disease; Micro RNA; Biological marker; Esophagitis; Glucocorticoid; Eosinophil; Gene silencing; Immunology; Digestive diseases; Reversibility

The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored. We aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers. Esophagea...