The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

• Published in: Nature (London) Vol. 583; no. 7818; pp. 830 - 833
• Main Authors: Bao, Linlin, Deng, Wei, Huang, Baoying, Gao, Hong, Liu, Jiangning, Ren, Lili, Wei, Qiang, Yu, Pin, Xu, Yanfeng, Qi, Feifei, Qu, Yajin, Li, Fengdi, Lv, Qi, Wang, Wenling, Xue, Jing, Gong, Shuran, Liu, Mingya, Wang, Guanpeng, Wang, Shunyi, Song, Zhiqi, Zhao, Linna, Liu, Peipei, Zhao, Li, Ye, Fei, Wang, Huijuan, Zhou, Weimin, Zhu, Na, Zhen, Wei, Yu, Haisheng, Zhang, Xiaojuan, Guo, Li, Chen, Lan, Wang, Conghui, Wang, Ying, Wang, Xinming, Xiao, Yan, Sun, Qiangming, Liu, Hongqi, Zhu, Fanli, Ma, Chunxia, Yan, Lingmei, Yang, Mengli, Han, Jun, Xu, Wenbo, Tan, Wenjie, Peng, Xiaozhong, Jin, Qi, Wu, Guizhen, Qin, Chuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.07.2020; Nature Publishing Group
• Subjects: 13/51; 38/77; 631/326/596/2078; 631/326/596/4130; 64/110; 692/420/254; ACE2; Alveoli; Analysis; Angiotensin; Angiotensin converting enzyme; Angiotensin-Converting Enzyme 2; Animals; Antigens; Antigens, Viral - immunology; Antigens, Viral - metabolism; Antiviral drugs; Betacoronavirus - immunology; Betacoronavirus - metabolism; Betacoronavirus - pathogenicity; Bronchi - pathology; Bronchi - virology; Chemical compounds; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - virology; Coronaviruses; COVID-19; Disease Models, Animal; Epithelial cells; Epithelial Cells - pathology; Epithelial Cells - virology; Fatalities; Female; Genetic aspects; Genetically modified mice; Histopathology; Humanities and Social Sciences; Humans; Immunoglobulin G - immunology; Infections; Lung - immunology; Lung - pathology; Lung - virology; Lungs; Lymphocytes; Lymphocytes - immunology; Macrophages; Macrophages, Alveolar - immunology; Macrophages, Alveolar - virology; Male; Mice; Mice, Transgenic; multidisciplinary; Neutrophils; Pandemics; Pathogenesis; Pathogenicity; Pathogens; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Pharmacology; Pneumonia; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Public health; Receptors, Complement 3d - genetics; Receptors, Complement 3d - metabolism; Respiratory diseases; Rodents; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Transgenes; Transgenic animals; Transgenic mice; Vaccines; Viral diseases; Viroids; Virus Replication; Viruses; Weight Loss; United States; China

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which has become a public health emergency of international concern 1 . Angiotensin-converting enzyme 2 (ACE2) is the cell-entry receptor for severe acute respiratory syndrome coronaviru...