Natural selection on protein-coding genes in the human genome

• Published in: Nature (London) Vol. 437; no. 7062; pp. 1153 - 1157
• Main Authors: Bustamante, Carlos D., Fledel-Alon, Adi, Williamson, Scott, Nielsen, Rasmus, Todd Hubisz, Melissa, Glanowski, Stephen, Tanenbaum, David M., White, Thomas J., Sninsky, John J., Hernandez, Ryan D., Civello, Daniel, Adams, Mark D., Cargill, Michele, Clark, Andrew G.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.10.2005; Nature Publishing; Nature Publishing Group
• Subjects: Amino Acid Substitution - genetics; Amino acids; Animals; Biological and medical sciences; Computational Biology; Cytoskeleton - metabolism; Deoxyribonucleic acid; Disease; DNA; Evolution; Evolution, Molecular; Fundamental and applied biological sciences. Psychology; Genes; Genes. Genome; Genetic Predisposition to Disease - genetics; Genome, Human; Genomics; Humanities and Social Sciences; Humans; letter; Male; Molecular and cellular biology; Molecular genetics; multidisciplinary; Pan troglodytes - genetics; Polymorphism, Genetic - genetics; Proteins; Proteins - genetics; Racial Groups - genetics; Science; Science (multidisciplinary); Selection, Genetic; Human; Molecular evolution; Gene; Genome; Protein; Polymorphism; Natural selection

Go forth and evolve Are we still evolving? The simple answer is yes. A comparison of the sequences of over 11,000 genes from 39 human individuals and from chimpanzees reveals more than 1,139 genes that show evidence of either positive or weak negative selection. Certain gene types (such as transcrip...