Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studies - Heinecke, Lowella; Proud, David; Sanders, Scherer; Schleimer, Robert P.; Kim, Jean (Journal of allergy and clinical immunology, 2008)
Keywords: Adult; Allergy and Immunology; Antigens, CD - biosynthesis; Asthma; B7 homologs; B7-1 Antigen - biosynthesis; B7-H1 Antigen; Biological and medical sciences; Bronchi - immunology; Bronchi - virology; cell-surface molecules; Cells, Cultured; Coculture Techniques; costimulatory ligands; Cytokines; double-stranded RNA; Epithelial Cells - immunology; Epithelial Cells - metabolism; Epithelial Cells - virology; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; human airway epithelial cells; Human subjects; Humans; Immune system; Immunopathology; Infections; Interferon-gamma - metabolism; Ligands; Lymphocytes; Male; Medical sciences; Middle Aged; Picornaviridae Infections - immunology; Programmed Cell Death 1 Ligand 2 Protein; Reverse Transcriptase Polymerase Chain Reaction; Rhinitis - immunology; Rhinitis - metabolism; Rhinitis - virology; Rhinovirus; rhinovirus infection; RNA, Double-Stranded; RNA, Messenger - analysis; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sinusitis - immunology; Sinusitis - metabolism; Sinusitis - virology; Th1 Cells - immunology; Toll-Like Receptor 3 - agonists; Viral infections; dsRNA; CRS; rhinovirus infection; B7 homologs; double-stranded RNA; JHMIRB; HRV; DMEM; PBEC; TCID 50; human airway epithelial cells; PNEC; cell-surface molecules; HBSS; costimulatory ligands; Chronic rhinosinusitis; Primary bronchial epithelial cell; Johns Hopkins Medicine Institutional Review Board; Human rhinovirus; Dulbecco modified Eagle medium; Hanks' balanced salt solution; Tissue culture infective dose; Primary nasal epithelial cell; Agonist; Double stranded RNA; Toll like receptor 3; Picornaviridae; Ligand; Respiratory system; Cell surface; Respiratory tract; Immunology; B7 molecule; Rhinovirus; Human; Immunopathology; Induction; In vitro; Costimulatory molecule; Virus; Infection; In vivo; Epithelial cell; B7-H1 molecule