Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation

• Published in: Brain, behavior, and immunity Vol. 52; no. oct 26; pp. 153 - 160
• Main Authors: Bersani, Francesco Saverio, Wolkowitz, Owen M., Lindqvist, Daniel, Yehuda, Rachel, Flory, Janine, Bierer, Linda M., Makotine, Iouri, Abu-Amara, Duna, Coy, Michelle, Reus, Victor I., Epel, Elissa S., Marmar, Charles, Mellon, Synthia H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2016
• Subjects: Adult; Allergy and Immunology; Arginine - blood; Biological Availability; Biomarkers - blood; C-Reactive Protein - metabolism; Case-Control Studies; Citrulline - blood; Clinical Medicine; Depressive Disorder - blood; Global arginine bioavailability ratio; Humans; Inflammation; Inflammation - blood; Interleukin-1beta - blood; Interleukin-6 - blood; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Nitric oxide; Nitric Oxide - biosynthesis; Ornithine - blood; Posttraumatic stress disorder; Psychiatric Status Rating Scales; Psychiatry; Psykiatri; Stress Disorders, Post-Traumatic - blood; Stress Disorders, Post-Traumatic - metabolism; Veterans - psychology; Global arginine bioavailability ratio; Posttraumatic stress disorder; Inflammation; Nitric oxide

•The “global arginine bioavailability ratio” (GABR) is a marker of nitric oxide production.•The GABR is decreased in male war veterans with PTSD.•The GABR is inversely associated with markers of inflammation.•The GABR is inversely associated with psychopathological severity. Psychiatric, physical an...