Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects

• Published in: FEBS letters Vol. 589; no. 3; pp. 364 - 373
• Main Authors: Amaiden, Marina R., Santander, Verónica S., Monesterolo, Noelia E., Nigra, Ayelen D., Rivelli, Juan F., Campetelli, Alexis N., Pie, Juan, Casale, Cesar H.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 30.01.2015
• Subjects: acetylated tubulin; AcTub; Adult; Detyrosinated tubulin; enzyme activity; Erythrocyte deformability; Erythrocyte Deformability - genetics; erythrocytes; Erythrocytes - enzymology; Erythrocytes - pathology; Female; GluTub; Human erythrocytes; Humans; Hypertension; Hypertension - genetics; Hypertension - metabolism; Hypertension - pathology; Male; Middle Aged; Na+,K+-ATPase; NKA; PAGE; phenylmethylsulfonyl fluoride; PMSF; polyacrylamide gel electrophoresis; sodium-potassium-exchanging ATPase; Sodium-Potassium-Exchanging ATPase - genetics; Sodium-Potassium-Exchanging ATPase - metabolism; TTCP; TTL; tubulin; Tubulin - metabolism; tubulin tyrosine carboxypeptidase; tubulin tyrosine ligase; tyrosinated tubulin; tyrosine; Tyrosine - metabolism; TyrTub; Hypertension; GluTub; TyrTub; Na+,K+-ATPase; NKA; TTCP; PAGE; TTL; Human erythrocytes; PMSF; Detyrosinated tubulin; AcTub; Erythrocyte deformability; Na(+),K(+)-ATPase

•Detyrosinated tubulin is able to inhibit the NKA activity.•Erythrocytes of hypertensive subjects have a reduced content and activity of TTL.•GluTub levels and NKA activity are related to erythrocyte deformability.•The mechanism explains involvement of tubulin in hypertension. Formation of tubulin/N...