Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects
•Detyrosinated tubulin is able to inhibit the NKA activity.•Erythrocytes of hypertensive subjects have a reduced content and activity of TTL.•GluTub levels and NKA activity are related to erythrocyte deformability.•The mechanism explains involvement of tubulin in hypertension. Formation of tubulin/N...
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| Published in | FEBS letters Vol. 589; no. 3; pp. 364 - 373 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
30.01.2015
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| Abstract | •Detyrosinated tubulin is able to inhibit the NKA activity.•Erythrocytes of hypertensive subjects have a reduced content and activity of TTL.•GluTub levels and NKA activity are related to erythrocyte deformability.•The mechanism explains involvement of tubulin in hypertension.
Formation of tubulin/Na+,K+-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development. |
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| AbstractList | Formation of tubulin/Na
+
,K
+
‐ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
Detyrosinated tubulin is able to inhibit the NKA activity.
Erythrocytes of hypertensive subjects have a reduced content and activity of TTL.
GluTub levels and NKA activity are related to erythrocyte deformability.
The mechanism explains involvement of tubulin in hypertension. Formation of tubulin/Na+,K+‐ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development. Detyrosinated tubulin is able to inhibit the NKA activity. Erythrocytes of hypertensive subjects have a reduced content and activity of TTL. GluTub levels and NKA activity are related to erythrocyte deformability. The mechanism explains involvement of tubulin in hypertension. Formation of tubulin/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development. •Detyrosinated tubulin is able to inhibit the NKA activity.•Erythrocytes of hypertensive subjects have a reduced content and activity of TTL.•GluTub levels and NKA activity are related to erythrocyte deformability.•The mechanism explains involvement of tubulin in hypertension. Formation of tubulin/Na+,K+-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development. Formation of tubulin/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.Formation of tubulin/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development. |
| Author | Casale, Cesar H. Nigra, Ayelen D. Santander, Verónica S. Pie, Juan Amaiden, Marina R. Monesterolo, Noelia E. Rivelli, Juan F. Campetelli, Alexis N. |
| Author_xml | – sequence: 1 givenname: Marina R. surname: Amaiden fullname: Amaiden, Marina R. organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina – sequence: 2 givenname: Verónica S. surname: Santander fullname: Santander, Verónica S. email: vsantander@exa.unrc.edu.ar organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina – sequence: 3 givenname: Noelia E. surname: Monesterolo fullname: Monesterolo, Noelia E. organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina – sequence: 4 givenname: Ayelen D. surname: Nigra fullname: Nigra, Ayelen D. organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina – sequence: 5 givenname: Juan F. surname: Rivelli fullname: Rivelli, Juan F. organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina – sequence: 6 givenname: Alexis N. surname: Campetelli fullname: Campetelli, Alexis N. organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina – sequence: 7 givenname: Juan surname: Pie fullname: Pie, Juan organization: Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology and Physiology, Medical School, University of Zaragoza, Spain – sequence: 8 givenname: Cesar H. surname: Casale fullname: Casale, Cesar H. organization: Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina |
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| Copyright | 2014 Federation of European Biochemical Societies FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
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| Keywords | Hypertension GluTub TyrTub Na+,K+-ATPase NKA TTCP PAGE TTL Human erythrocytes PMSF Detyrosinated tubulin AcTub Erythrocyte deformability Na(+),K(+)-ATPase |
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Estudio en diabéticos e hipertensos publication-title: Acta Bioquim. Clin. Latinoam. |
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| Snippet | •Detyrosinated tubulin is able to inhibit the NKA activity.•Erythrocytes of hypertensive subjects have a reduced content and activity of TTL.•GluTub levels and... Formation of tubulin/Na+,K+‐ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that... Formation of tubulin/Na + ,K + ‐ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here... Formation of tubulin/Na(+),K(+)-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here... Formation of tubulin/Na+,K+-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that... |
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| SubjectTerms | acetylated tubulin AcTub Adult Detyrosinated tubulin enzyme activity Erythrocyte deformability Erythrocyte Deformability - genetics erythrocytes Erythrocytes - enzymology Erythrocytes - pathology Female GluTub Human erythrocytes Humans Hypertension Hypertension - genetics Hypertension - metabolism Hypertension - pathology Male Middle Aged Na+,K+-ATPase NKA PAGE phenylmethylsulfonyl fluoride PMSF polyacrylamide gel electrophoresis sodium-potassium-exchanging ATPase Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism TTCP TTL tubulin Tubulin - metabolism tubulin tyrosine carboxypeptidase tubulin tyrosine ligase tyrosinated tubulin tyrosine Tyrosine - metabolism TyrTub |
| Title | Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects |
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