A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis - Marcoux, Julien; Mangione, P Patrizia; Porcari, Riccardo; Degiacomi, Matteo T; Verona, Guglielmo; Taylor, Graham W; Giorgetti, Sofia; Raimondi, Sara; Sanglier‐Cianférani, Sarah; Benesch, Justin LP; Cecconi, Ciro; Naqvi, Mohsin M; et al. (EMBO molecular medicine, 2015)
Keywords: Amyloid; Amyloid Neuropathies, Familial - etiology; Amyloid Neuropathies, Familial - metabolism; Amyloidogenesis; Amyloidosis; Binding sites; Biochemistry, Molecular Biology; Chromatography; EMBO16; Fibrillogenesis; Fluid flow; Heart; Humans; Life Sciences; mechano‐enzymatic cleavage; Mutation; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Peptides; Physiology; Prealbumin - chemistry; Prealbumin - metabolism; Proteins; Proteolysis; Research Article; Structural Biology; Transthyretin; transthyretin; mechano‐enzymatic cleavage; amyloid; transthyretin Subject Categories Genetics; mechano-enzymatic cleavage; Gene Therapy & Genetic Disease