Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fib...
Saved in:
| Published in | Nature biotechnology Vol. 28; no. 8; pp. 848 - 855 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Nature Publishing Group
01.08.2010
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences. Our results suggest that early-passage iPSCs retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages. |
|---|---|
| AbstractList | Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences. Our results suggest that early-passage iPSCs retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages. Polo et al. show that early-passage induced pluripotent stem cells retain an epigenetic memory of their cell type of origin. These epigenetic differences affect the cells' differentiation potential and might be exploited to generate particular cell types of interest. Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences. Our results suggest that early-passage iPSCs retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages. Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies and different hematopoietic cell types. Notably, continuous passaging of iPSCs largely attenuates these differences. Our results suggest that early-passage iPSCs retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations may influence ongoing attempts to use iPSCs for disease modeling and could also be exploited in potential therapeutic applications to enhance differentiation into desired cell lineages. [PUBLICATION ABSTRACT] |
| Audience | Academic |
| Author | Figueroa, Maria Eugenia Kulalert, Warakorn Tan, Kah Yong Melnick, Ari Li, Yushan Polo, Jose M Wagers, Amy J Liu, Susanna Shioda, Toshi Apostolou, Effie Hochedlinger, Konrad Eminli, Sarah Natesan, Sridaran Evans, Todd Stadtfeld, Matthias |
| AuthorAffiliation | 2 Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA 4 Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 7 Joslin Diabetes Center, Boston, Massachusetts, USA 8 Sanofi-Aventis Cambridge Genomics Center, Cambridge, Massachusetts, USA 1 Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, Massachusetts, USA 3 Massachusetts General Hospital Center for Regenerative Medicine, Boston, Massachusetts, USA 5 Department of Surgery, Weill Cornell Medical College, New York, New York, USA 6 Department of Medicine, Hematology Oncology Division, Weill Cornell Medical College, New York, New York, USA |
| AuthorAffiliation_xml | – name: 8 Sanofi-Aventis Cambridge Genomics Center, Cambridge, Massachusetts, USA – name: 7 Joslin Diabetes Center, Boston, Massachusetts, USA – name: 4 Harvard Stem Cell Institute, Cambridge, Massachusetts, USA – name: 6 Department of Medicine, Hematology Oncology Division, Weill Cornell Medical College, New York, New York, USA – name: 2 Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA – name: 3 Massachusetts General Hospital Center for Regenerative Medicine, Boston, Massachusetts, USA – name: 1 Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, Massachusetts, USA – name: 5 Department of Surgery, Weill Cornell Medical College, New York, New York, USA |
| Author_xml | – givenname: Amy J surname: Wagers fullname: Wagers, Amy J organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Harvard Stem Cell Institute Joslin Diabetes Center – givenname: Sarah surname: Eminli fullname: Eminli, Sarah organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Massachusetts General Hospital Cancer Center Massachusetts General Hospital Center for Regenerative Medicine Harvard Stem Cell Institute – givenname: Todd surname: Evans fullname: Evans, Todd organization: Department of Surgery, Weill Cornell Medical College – givenname: Susanna surname: Liu fullname: Liu, Susanna organization: Department of Surgery, Weill Cornell Medical College – givenname: Warakorn surname: Kulalert fullname: Kulalert, Warakorn organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Massachusetts General Hospital Cancer Center Massachusetts General Hospital Center for Regenerative Medicine Harvard Stem Cell Institute – givenname: Yushan surname: Li fullname: Li, Yushan organization: Department of Medicine, Hematology Oncology Division, Weill Cornell Medical College – givenname: Effie surname: Apostolou fullname: Apostolou, Effie organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Massachusetts General Hospital Cancer Center Massachusetts General Hospital Center for Regenerative Medicine Harvard Stem Cell Institute – givenname: Kah Yong surname: Tan fullname: Tan, Kah Yong organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Harvard Stem Cell Institute Joslin Diabetes Center – givenname: Sridaran surname: Natesan fullname: Natesan, Sridaran organization: Sanofi-Aventis Cambridge Genomics Center – givenname: Ari surname: Melnick fullname: Melnick, Ari organization: Department of Medicine, Hematology Oncology Division, Weill Cornell Medical College – givenname: Jose M surname: Polo fullname: Polo, Jose M organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Massachusetts General Hospital Cancer Center Massachusetts General Hospital Center for Regenerative Medicine Harvard Stem Cell Institute – givenname: Toshi surname: Shioda fullname: Shioda, Toshi organization: Massachusetts General Hospital Cancer Center – givenname: Konrad surname: Hochedlinger fullname: Hochedlinger, Konrad organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Massachusetts General Hospital Cancer Center Massachusetts General Hospital Center for Regenerative Medicine Harvard Stem Cell Institute – givenname: Matthias surname: Stadtfeld fullname: Stadtfeld, Matthias organization: Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School Massachusetts General Hospital Cancer Center Massachusetts General Hospital Center for Regenerative Medicine Harvard Stem Cell Institute – givenname: Maria Eugenia surname: Figueroa fullname: Figueroa, Maria Eugenia organization: Department of Medicine, Hematology Oncology Division, Weill Cornell Medical College |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23147048$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20644536$$D View this record in MEDLINE/PubMed |
| BookMark | eNqN0llr3DAQAGBTUpqjhf6CIlpKW-imki3L8kshLD0CgUCvVyHL410FWXJ0lOTfR2a3m2xf2hdboG9GGs0cFwfWWSiK5wSfElzxD7aLp4Sx5lFxRGrKFoS17CCvMW8WmNTssDgO4QpjzChjT4rDMi9oXbGjwi7BGBRvJ0BuQM7rlbZI28EksAoCimtAozOgkpEeSdujIVkVtbPSoMm7CXzU2eXg0aUAObZPCno0meT15CLYiEKEEal8UHhaPB6kCfBs-z8pfn7-9GP5dXFx-eV8eXaxUIyXcQEtb1kDVUdbyWVT90MvVa8oq5iqBw6dKivedoNScxmdbMtB1l1HecehJD2rToqPm7xT6kboVb6Fl0ZMXo_S3wontdjfsXotVu63qAjlDNc5wZttAu-uE4QoRh3mEqSFXKfgDSW84mX7T9lQ3maGZ_nyL3nlks8POSNCq9zJJqNXG7SSBkTuhMv3U3NKccZKwlnTcJrVuz2lnI1wE1cyhSDOv3_7f3v5a9--f2C7FLSFkD9Br9YxbEL2-NsNV96F4GHYvTDBYp5MkSdTzJOZ6YuHHdnBP6OYwestkEFJM3hplQ73LnemwZTfJ7IyJg87sDvpDiI2-Bs |
| CODEN | NABIF9 |
| CitedBy_id | crossref_primary_10_1093_molehr_gat054 crossref_primary_10_1002_stem_1340 crossref_primary_10_1016_j_aanat_2011_06_004 crossref_primary_10_1016_j_celrep_2020_107870 crossref_primary_10_1016_j_devcel_2010_10_014 crossref_primary_10_1371_journal_pone_0085138 crossref_primary_10_1016_j_semcdb_2017_10_031 crossref_primary_10_1089_cell_2011_0002 crossref_primary_10_1016_j_molmed_2012_06_002 crossref_primary_10_3390_cells10061470 crossref_primary_10_1101_gad_1963910 crossref_primary_10_1016_j_scr_2014_03_007 crossref_primary_10_1016_j_gde_2012_05_005 crossref_primary_10_1016_j_theriogenology_2012_05_030 crossref_primary_10_12691_ajbr_1_3_2 crossref_primary_10_1016_j_bbrc_2011_12_052 crossref_primary_10_1038_nrm2962 crossref_primary_10_1007_s11033_012_2445_7 crossref_primary_10_1038_nrc3034 crossref_primary_10_1371_journal_pone_0108350 crossref_primary_10_1016_j_scr_2021_102287 crossref_primary_10_1016_j_toxrep_2014_11_016 crossref_primary_10_5339_gcsp_2014_44 crossref_primary_10_1016_j_celrep_2017_12_098 crossref_primary_10_1371_journal_pgen_1004432 crossref_primary_10_1093_stmcls_sxac020 crossref_primary_10_1155_2019_4252514 crossref_primary_10_1016_j_gpb_2013_09_006 crossref_primary_10_1371_journal_pone_0061396 crossref_primary_10_1093_humrep_des204 crossref_primary_10_4061_2011_765378 crossref_primary_10_1038_nbt_2658 crossref_primary_10_1111_j_1600_0765_2011_01358_x crossref_primary_10_1155_2012_434529 crossref_primary_10_1002_jcb_24436 crossref_primary_10_3724_SP_J_1005_2011_00449 crossref_primary_10_1155_2014_768391 crossref_primary_10_1038_473272a crossref_primary_10_1371_journal_pone_0157974 crossref_primary_10_1093_hmg_ddq542 crossref_primary_10_1371_journal_pgen_1003574 crossref_primary_10_2217_fnl_16_7 crossref_primary_10_1186_scrt85 crossref_primary_10_1080_15265161_2011_593683 crossref_primary_10_1016_j_cell_2011_01_032 crossref_primary_10_1111_acel_12182 crossref_primary_10_1186_s40880_018_0313_0 crossref_primary_10_1007_s11936_014_0320_7 crossref_primary_10_1089_ten_teb_2018_0124 crossref_primary_10_1016_j_stemcr_2017_05_009 crossref_primary_10_3390_dj4020019 crossref_primary_10_1242_dev_097170 crossref_primary_10_5021_ad_2017_29_6_667 crossref_primary_10_1007_s11892_017_0901_4 crossref_primary_10_1186_s13041_016_0267_6 crossref_primary_10_1155_2017_7492914 crossref_primary_10_1042_EBC20190029 crossref_primary_10_1007_s12033_013_9702_4 crossref_primary_10_1089_cell_2012_0043 crossref_primary_10_1093_carcin_bgw092 crossref_primary_10_1084_jem_20200474 crossref_primary_10_1007_s11934_013_0379_9 crossref_primary_10_1007_s00335_020_09849_x crossref_primary_10_1038_nrg2849 crossref_primary_10_3727_096368915X688632 crossref_primary_10_1371_journal_pone_0030234 crossref_primary_10_3390_genes14061143 crossref_primary_10_1186_scrt185 crossref_primary_10_1016_j_ddmod_2012_04_002 crossref_primary_10_1089_cell_2012_0037 crossref_primary_10_1186_scrt99 crossref_primary_10_3390_ijms241512433 crossref_primary_10_1146_annurev_bioeng_071910_124715 crossref_primary_10_1590_1806_9282_63_02_180 crossref_primary_10_1172_jci_insight_85558 crossref_primary_10_1111_j_1749_6632_2011_06038_x crossref_primary_10_3892_ijmm_2023_5273 crossref_primary_10_1111_cpr_13248 crossref_primary_10_1152_ajplung_00255_2011 crossref_primary_10_1007_s13770_023_00554_9 crossref_primary_10_1186_s13287_021_02364_z crossref_primary_10_1371_journal_pgen_1005793 crossref_primary_10_1016_j_ceb_2012_10_004 crossref_primary_10_1111_cpr_13486 crossref_primary_10_1038_s41598_018_30784_0 crossref_primary_10_1089_cell_2012_0060 crossref_primary_10_1098_rstb_2014_0367 crossref_primary_10_2217_epi_11_66 crossref_primary_10_1080_15592294_2021_1900027 crossref_primary_10_1016_j_stem_2011_09_002 crossref_primary_10_1089_scd_2013_0111 crossref_primary_10_3390_cells12222635 crossref_primary_10_1016_j_stem_2011_09_004 crossref_primary_10_1155_2017_1376151 crossref_primary_10_1042_BCJ20160008 crossref_primary_10_1093_nar_gkz005 crossref_primary_10_1038_nmeth_1699 crossref_primary_10_9794_jspccs_31_138 crossref_primary_10_1089_scd_2017_0055 crossref_primary_10_1038_ncomms14477 crossref_primary_10_1073_pnas_2300839120 crossref_primary_10_1096_fj_202301182R crossref_primary_10_1155_2016_7235757 crossref_primary_10_1371_journal_pone_0149291 crossref_primary_10_3727_096368912X662453 crossref_primary_10_1016_j_biomaterials_2014_10_055 crossref_primary_10_1038_jid_2011_436 crossref_primary_10_1002_jcb_25596 crossref_primary_10_1002_jcb_25355 crossref_primary_10_1089_scd_2011_0283 crossref_primary_10_1371_journal_pone_0091416 crossref_primary_10_1016_j_mad_2018_05_009 crossref_primary_10_1177_2155179017733172 crossref_primary_10_1177_2155179017733177 crossref_primary_10_1111_jcmm_14316 crossref_primary_10_1186_1471_2202_12_82 crossref_primary_10_1155_2017_8073721 crossref_primary_10_1155_2019_7858796 crossref_primary_10_1101_cshperspect_a041371 crossref_primary_10_1007_s12015_023_10627_w crossref_primary_10_1002_stem_1734 crossref_primary_10_1089_scd_2014_0110 crossref_primary_10_1681_ASN_2012121199 crossref_primary_10_1089_scd_2011_0026 crossref_primary_10_1182_blood_2013_01_478412 crossref_primary_10_1038_nrg3563 crossref_primary_10_1517_14712598_2011_558837 crossref_primary_10_1038_ncomms6613 crossref_primary_10_1371_journal_pone_0017829 crossref_primary_10_1016_j_nbt_2011_03_011 crossref_primary_10_1111_j_1749_6632_2011_06093_x crossref_primary_10_1038_ncomms6605 crossref_primary_10_1002_jcp_22450 crossref_primary_10_3389_fcell_2023_1188905 crossref_primary_10_1016_j_coph_2011_05_007 crossref_primary_10_1016_j_mam_2012_08_002 crossref_primary_10_1089_scd_2014_0120 crossref_primary_10_1371_journal_pone_0028719 crossref_primary_10_1371_journal_pone_0163580 crossref_primary_10_1093_toxsci_kfq370 crossref_primary_10_1146_annurev_genom_082410_101506 crossref_primary_10_1371_journal_pone_0106110 crossref_primary_10_1586_erc_10_121 crossref_primary_10_1073_pnas_1516394112 crossref_primary_10_1177_2472630317712220 crossref_primary_10_1681_ASN_2010101022 crossref_primary_10_1089_scd_2011_0010 crossref_primary_10_1172_JCI43853 crossref_primary_10_1111_j_1476_5381_2012_01965_x crossref_primary_10_1016_j_celrep_2018_01_075 crossref_primary_10_1242_dev_114249 crossref_primary_10_1242_dev_182170 crossref_primary_10_1038_mt_2011_165 crossref_primary_10_1242_dev_091439 crossref_primary_10_1016_j_stem_2012_05_019 crossref_primary_10_1038_nbt_1933 crossref_primary_10_1002_sctm_16_0029 crossref_primary_10_1016_j_semnephrol_2012_07_011 crossref_primary_10_1038_ncb0511_523 crossref_primary_10_1172_JCI85002 crossref_primary_10_1038_s41598_018_35546_6 crossref_primary_10_1242_jcs_099192 crossref_primary_10_15311_selcukdentj_305565 crossref_primary_10_1126_scitranslmed_3002376 crossref_primary_10_1038_cr_2011_28 crossref_primary_10_1038_cr_2013_1 crossref_primary_10_3390_ijms19040930 crossref_primary_10_1089_scd_2014_0395 crossref_primary_10_5966_sctm_2014_0076 crossref_primary_10_1089_scd_2021_0316 crossref_primary_10_5194_pb_4_153_2017 crossref_primary_10_1038_cddis_2014_499 crossref_primary_10_1016_j_preteyeres_2018_04_006 crossref_primary_10_1038_mt_2011_140 crossref_primary_10_1002_ange_201306722 crossref_primary_10_1038_s41420_018_0102_1 crossref_primary_10_1155_2016_9451492 crossref_primary_10_1038_aps_2013_21 crossref_primary_10_4061_2011_212487 crossref_primary_10_2492_inflammregen_31_33 crossref_primary_10_1186_2044_5040_2_4 crossref_primary_10_1016_j_bbamcr_2014_07_013 crossref_primary_10_1016_j_molcel_2019_02_024 crossref_primary_10_1007_s12015_015_9622_8 crossref_primary_10_1161_CIRCRESAHA_115_301517 crossref_primary_10_1016_j_stem_2017_03_003 crossref_primary_10_1038_leu_2012_363 crossref_primary_10_1016_j_tibtech_2016_05_010 crossref_primary_10_1016_j_stem_2014_07_003 crossref_primary_10_1177_1074248414527641 crossref_primary_10_1038_cr_2011_201 crossref_primary_10_1038_474165a crossref_primary_10_1038_nbt_1946 crossref_primary_10_1016_j_yjmcc_2013_04_022 crossref_primary_10_1101_gr_155960_113 crossref_primary_10_1016_j_diff_2011_01_003 crossref_primary_10_1038_emm_2017_10 crossref_primary_10_1371_journal_pone_0158046 crossref_primary_10_1038_s41467_021_25249_4 crossref_primary_10_1002_cphg_26 crossref_primary_10_1089_scd_2015_0235 crossref_primary_10_1016_j_diff_2014_09_001 crossref_primary_10_1016_j_celrep_2014_08_014 crossref_primary_10_1016_j_biomaterials_2012_03_011 crossref_primary_10_1038_s41598_022_19018_6 crossref_primary_10_1016_j_semnephrol_2014_06_012 crossref_primary_10_1177_0022034515599769 crossref_primary_10_1016_j_bbagen_2012_10_014 crossref_primary_10_1016_j_nbd_2018_04_021 crossref_primary_10_1371_journal_pone_0038833 crossref_primary_10_1155_2016_3451807 crossref_primary_10_3233_JHD_160199 crossref_primary_10_1038_cdd_2011_205 crossref_primary_10_1681_ASN_2011050501 crossref_primary_10_1038_467280a crossref_primary_10_1186_s12967_016_1101_8 crossref_primary_10_1098_rsob_210268 crossref_primary_10_1161_CIRCRESAHA_111_250126 crossref_primary_10_1007_s12015_020_09956_x crossref_primary_10_1002_anie_201306722 crossref_primary_10_1089_scd_2015_0248 crossref_primary_10_1093_nar_gkr1015 crossref_primary_10_1101_gad_295741_116 crossref_primary_10_1016_j_gde_2021_04_007 crossref_primary_10_1186_s13059_021_02293_3 crossref_primary_10_1016_j_stem_2011_06_007 crossref_primary_10_1007_s12015_013_9487_7 crossref_primary_10_1186_2045_9769_1_5 crossref_primary_10_1038_nrm3584 crossref_primary_10_1111_joim_12033 crossref_primary_10_1186_s13148_024_01639_5 crossref_primary_10_3390_cells9030756 crossref_primary_10_1016_j_ddmod_2012_06_002 crossref_primary_10_1111_febs_13763 crossref_primary_10_1016_j_molcel_2012_09_008 crossref_primary_10_1007_s11434_015_0796_x crossref_primary_10_1007_s13238_011_1025_2 crossref_primary_10_1038_s41598_018_32116_8 crossref_primary_10_1161_CIRCRESAHA_114_300556 crossref_primary_10_1155_2019_7360121 crossref_primary_10_1016_j_cell_2010_12_032 crossref_primary_10_1038_s41598_021_85230_5 crossref_primary_10_1016_j_addr_2017_10_007 crossref_primary_10_3389_fendo_2020_614234 crossref_primary_10_3390_jcm9092838 crossref_primary_10_1007_s12013_012_9487_2 crossref_primary_10_1016_j_stem_2013_09_014 crossref_primary_10_1007_s13238_012_2922_8 crossref_primary_10_1021_acsami_4c04451 crossref_primary_10_1146_annurev_med_050311_163324 crossref_primary_10_1186_2045_9769_1_7 crossref_primary_10_1371_journal_pone_0123193 crossref_primary_10_1093_brain_awaa268 crossref_primary_10_5966_sctm_2011_0025 crossref_primary_10_1002_jor_24493 crossref_primary_10_1016_j_brainres_2018_02_045 crossref_primary_10_1007_s12072_011_9300_0 crossref_primary_10_1016_j_cell_2010_10_008 crossref_primary_10_1016_j_stem_2012_01_005 crossref_primary_10_1002_jcb_29351 crossref_primary_10_1101_gad_230318_113 crossref_primary_10_3390_ijms17020199 crossref_primary_10_1586_epr_10_100 crossref_primary_10_1002_path_4551 crossref_primary_10_1016_j_stemcr_2018_12_018 crossref_primary_10_1007_s10522_013_9455_2 crossref_primary_10_1093_eurheartj_ehs203 crossref_primary_10_1007_s00774_013_0547_5 crossref_primary_10_1161_CIRCRESAHA_117_311080 crossref_primary_10_1089_scd_2014_0540 crossref_primary_10_3390_ijms21238910 crossref_primary_10_1073_pnas_1211175109 crossref_primary_10_1016_j_bbamcr_2013_03_025 crossref_primary_10_1177_1073858420912404 crossref_primary_10_3390_ijms17010141 crossref_primary_10_1016_j_stemcr_2020_09_002 crossref_primary_10_1530_REP_14_0410 crossref_primary_10_1016_j_stem_2011_05_012 crossref_primary_10_3390_cells8060571 crossref_primary_10_3390_ijms19103119 crossref_primary_10_1371_journal_pone_0018293 crossref_primary_10_1371_journal_pone_0221762 crossref_primary_10_1016_j_jdsr_2022_03_002 crossref_primary_10_1007_s12015_011_9294_y crossref_primary_10_1021_acs_chemrestox_6b00150 crossref_primary_10_1016_j_bbcan_2020_188349 crossref_primary_10_1007_s13238_011_1012_7 crossref_primary_10_1016_j_stem_2014_05_002 crossref_primary_10_4252_wjsc_v13_i7_914 crossref_primary_10_1002_jcp_24437 crossref_primary_10_1016_j_fertnstert_2019_10_012 crossref_primary_10_1371_journal_pone_0243769 crossref_primary_10_1002_cphg_47 crossref_primary_10_1007_s11357_020_00284_z crossref_primary_10_3109_03009734_2012_665096 crossref_primary_10_3389_fphys_2014_00119 crossref_primary_10_1016_j_scr_2011_09_001 crossref_primary_10_3390_pharmaceutics13060780 crossref_primary_10_1093_hmg_dds471 crossref_primary_10_2217_epi_2017_0098 crossref_primary_10_1038_nrg3473 crossref_primary_10_1016_j_intimp_2014_06_011 crossref_primary_10_1016_j_stemcr_2017_09_020 crossref_primary_10_1038_nm1010_1082 crossref_primary_10_1016_j_stemcr_2017_09_024 crossref_primary_10_3389_fcell_2014_00046 crossref_primary_10_1089_ten_teb_2013_0301 crossref_primary_10_1074_jbc_M113_466144 crossref_primary_10_1016_j_pbiomolbio_2012_07_013 crossref_primary_10_1158_2159_8290_CD_12_0208 crossref_primary_10_1155_2011_412743 crossref_primary_10_4161_cc_26952 crossref_primary_10_1556_ABiol_65_2014_3_9 crossref_primary_10_1016_j_stem_2022_07_004 crossref_primary_10_1038_nature13551 crossref_primary_10_1002_stem_3353 crossref_primary_10_1186_s13619_015_0024_9 crossref_primary_10_2217_rme_12_20 crossref_primary_10_1161_CIRCRESAHA_111_240374 crossref_primary_10_1089_cell_2013_0083 crossref_primary_10_1016_j_semcancer_2015_07_001 crossref_primary_10_1038_cmi_2013_62 crossref_primary_10_1038_nrd3263 crossref_primary_10_1089_cell_2023_0073 crossref_primary_10_1089_scd_2010_0574 crossref_primary_10_1182_blood_2012_11_469080 crossref_primary_10_1371_journal_pone_0056095 crossref_primary_10_1016_j_arr_2017_09_002 crossref_primary_10_1016_j_stem_2014_02_003 crossref_primary_10_1007_s13238_012_2920_x crossref_primary_10_1016_j_arr_2013_01_001 crossref_primary_10_1016_j_cmet_2013_08_010 crossref_primary_10_1038_nbt_2052 crossref_primary_10_1016_j_addr_2018_03_002 crossref_primary_10_1016_j_ypmed_2011_11_013 crossref_primary_10_1089_scd_2011_0707 crossref_primary_10_1002_cyto_a_23163 crossref_primary_10_1002_sctm_19_0344 crossref_primary_10_1371_journal_pgen_1002085 crossref_primary_10_3727_096368911X627507 crossref_primary_10_1038_nn_3425 crossref_primary_10_1098_rstb_2013_0511 crossref_primary_10_1007_s12015_015_9594_8 crossref_primary_10_1007_s00204_010_0641_6 crossref_primary_10_1186_s13287_018_0947_5 crossref_primary_10_1007_s40778_014_0009_6 crossref_primary_10_1111_pcmr_13092 crossref_primary_10_1089_scd_2012_0461 crossref_primary_10_1186_1471_2156_14_32 crossref_primary_10_4161_org_7_2_15783 crossref_primary_10_3390_diseases9040068 crossref_primary_10_1016_j_ymeth_2015_08_015 crossref_primary_10_1016_j_tibtech_2011_09_002 crossref_primary_10_3727_215517914X685178 crossref_primary_10_1002_cyto_a_22069 crossref_primary_10_1016_j_jbior_2023_100993 crossref_primary_10_1007_s13577_016_0139_5 crossref_primary_10_1016_j_gde_2012_07_003 crossref_primary_10_1016_j_stem_2010_10_009 crossref_primary_10_1557_jmr_2018_132 crossref_primary_10_1042_BJ20140400 crossref_primary_10_2217_rme_13_100 crossref_primary_10_2217_nnm_2017_0001 crossref_primary_10_1016_j_stem_2010_11_018 crossref_primary_10_3390_ph10020054 crossref_primary_10_1002_sctm_17_0021 crossref_primary_10_1016_j_ddmod_2012_02_003 crossref_primary_10_1016_j_ddmod_2012_02_004 crossref_primary_10_1126_science_1199006 crossref_primary_10_1098_rstb_2011_0042 crossref_primary_10_2478_s13380_012_0016_y crossref_primary_10_1016_j_gde_2017_06_007 crossref_primary_10_1155_2016_5961342 crossref_primary_10_5045_br_2013_48_2_76 crossref_primary_10_1038_nrm_2016_6 crossref_primary_10_1016_j_nbd_2016_11_007 crossref_primary_10_1371_journal_pone_0119275 crossref_primary_10_1371_journal_pone_0064503 crossref_primary_10_3390_biomedicines10061358 crossref_primary_10_1371_journal_pone_0017128 crossref_primary_10_3727_096368912X655208 crossref_primary_10_1152_physrev_00039_2017 crossref_primary_10_1016_j_tips_2011_03_002 crossref_primary_10_1002_stem_1138 crossref_primary_10_4061_2011_348960 crossref_primary_10_1098_rstb_2011_0017 crossref_primary_10_1016_j_stemcr_2017_06_004 crossref_primary_10_1089_ten_teb_2010_0549 crossref_primary_10_1098_rstb_2011_0016 crossref_primary_10_1186_2045_8118_10_2 crossref_primary_10_1124_mol_112_080697 crossref_primary_10_1016_j_stem_2011_07_006 crossref_primary_10_1038_nrm3543 crossref_primary_10_1093_hmg_ddy186 crossref_primary_10_1186_s12929_023_00970_y crossref_primary_10_1002_bies_201400072 crossref_primary_10_3390_ijms21114115 crossref_primary_10_1016_j_biomaterials_2012_04_001 crossref_primary_10_1002_jcb_30164 crossref_primary_10_1002_stem_1169 crossref_primary_10_1016_j_stem_2016_06_019 crossref_primary_10_1098_rstb_2011_0026 crossref_primary_10_1016_j_stem_2016_06_017 crossref_primary_10_1053_j_gastro_2012_01_004 crossref_primary_10_1242_jcs_203018 crossref_primary_10_1073_pnas_1209979109 crossref_primary_10_1007_s12015_011_9324_9 crossref_primary_10_7554_eLife_83138 crossref_primary_10_1038_s41598_019_46359_6 crossref_primary_10_1111_ans_12419 crossref_primary_10_3390_cells10071565 crossref_primary_10_1038_s41598_022_24581_z crossref_primary_10_1016_j_neuropharm_2011_02_021 crossref_primary_10_1186_2045_9769_3_4 crossref_primary_10_1111_hepr_12329 crossref_primary_10_1007_s00109_012_0913_0 crossref_primary_10_3390_ijms18091952 crossref_primary_10_1126_scitranslmed_3003920 crossref_primary_10_1111_jcmm_12646 crossref_primary_10_1111_ajt_15900 crossref_primary_10_1007_s00018_012_0942_4 crossref_primary_10_1155_2018_5653787 crossref_primary_10_1093_hmg_ddq404 crossref_primary_10_1002_stem_2795 crossref_primary_10_1038_s41467_017_01077_3 crossref_primary_10_1016_j_compbiolchem_2020_107227 crossref_primary_10_7554_eLife_58178 crossref_primary_10_1002_hipo_23502 crossref_primary_10_1371_journal_pcbi_1007910 crossref_primary_10_1038_nrgastro_2012_140 crossref_primary_10_1074_jbc_M115_683466 crossref_primary_10_3390_cells11091404 crossref_primary_10_3389_fnins_2017_00494 crossref_primary_10_1038_s41467_018_06398_5 crossref_primary_10_1371_journal_pone_0120585 crossref_primary_10_1038_nature12299 crossref_primary_10_1002_stem_2303 crossref_primary_10_1016_j_drudis_2011_04_007 crossref_primary_10_1038_mp_2017_40 crossref_primary_10_1038_nbt_1684 crossref_primary_10_1186_2049_1891_3_5 crossref_primary_10_1002_1873_3468_13656 crossref_primary_10_1038_mt_2010_269 crossref_primary_10_1155_2021_5511630 crossref_primary_10_3390_ijms21124354 crossref_primary_10_1089_scd_2013_0206 crossref_primary_10_4252_wjsc_v8_i2_32 crossref_primary_10_1016_j_cell_2012_11_039 crossref_primary_10_1371_journal_pone_0017557 crossref_primary_10_3389_fncel_2021_660748 crossref_primary_10_1074_jbc_M113_502492 crossref_primary_10_1128_MCB_00027_15 crossref_primary_10_1016_j_diff_2014_05_003 crossref_primary_10_1089_cell_2015_0013 crossref_primary_10_1016_j_jpor_2012_06_001 crossref_primary_10_1038_clpt_2011_1 crossref_primary_10_1134_S0026893319050042 crossref_primary_10_1161_ATVBAHA_122_318723 crossref_primary_10_1242_dev_086165 crossref_primary_10_1242_jcs_124925 crossref_primary_10_1155_2016_8415010 crossref_primary_10_1242_bio_022111 crossref_primary_10_1016_j_compbiolchem_2011_05_002 crossref_primary_10_1186_s13287_020_01907_0 crossref_primary_10_1016_j_semcdb_2016_01_028 crossref_primary_10_1089_scd_2017_0162 crossref_primary_10_3389_fbioe_2023_1108340 crossref_primary_10_1016_j_bbagrm_2011_06_009 crossref_primary_10_1016_j_celrep_2016_11_080 crossref_primary_10_1038_nature14046 crossref_primary_10_1002_1873_3468_13681 crossref_primary_10_1038_nature14047 crossref_primary_10_1073_pnas_1413481111 crossref_primary_10_1371_journal_pone_0015590 crossref_primary_10_1016_j_eururo_2013_03_054 crossref_primary_10_1038_s41467_022_35180_x crossref_primary_10_1242_dmm_012054 crossref_primary_10_1007_s13238_010_0142_7 crossref_primary_10_1016_j_molmed_2011_05_001 crossref_primary_10_1002_stem_1425 crossref_primary_10_1111_j_1445_2197_2012_06282_x crossref_primary_10_1038_nm_4238 crossref_primary_10_1007_s12015_014_9538_8 crossref_primary_10_1016_j_nbas_2023_100101 crossref_primary_10_4236_jbise_2016_94017 crossref_primary_10_5527_wjn_v5_i1_43 crossref_primary_10_1016_j_stem_2011_11_003 crossref_primary_10_1002_sctm_18_0283 crossref_primary_10_2217_rme_13_37 crossref_primary_10_1186_s13287_015_0005_5 crossref_primary_10_1038_nrg2955 crossref_primary_10_3390_ijms21165705 crossref_primary_10_1371_journal_pone_0041007 crossref_primary_10_1007_s11910_019_0920_4 crossref_primary_10_3390_cells9061527 crossref_primary_10_1139_y11_125 crossref_primary_10_1038_ncb0511_497 crossref_primary_10_3390_ijms241914408 crossref_primary_10_1096_fj_201900578RR crossref_primary_10_18632_oncotarget_26235 crossref_primary_10_1007_s12015_011_9320_0 crossref_primary_10_1016_j_stem_2016_04_006 crossref_primary_10_1016_j_stem_2016_04_004 crossref_primary_10_1038_cr_2011_177 crossref_primary_10_1016_j_ynpai_2020_100055 crossref_primary_10_1038_cr_2011_171 crossref_primary_10_3960_jslrt_54_67 crossref_primary_10_1093_molehr_gaq091 crossref_primary_10_4049_jimmunol_1601676 crossref_primary_10_1038_mt_2011_41 crossref_primary_10_1186_s41241_017_0015_y crossref_primary_10_1258_ebm_2011_011107 crossref_primary_10_1016_j_biopsych_2021_04_008 crossref_primary_10_1371_journal_pone_0035824 crossref_primary_10_1002_path_2845 crossref_primary_10_2217_rme_2016_0117 crossref_primary_10_1242_dev_138982 crossref_primary_10_3389_fvets_2015_00055 crossref_primary_10_3390_jcm10030454 crossref_primary_10_5966_sctm_2013_0138 crossref_primary_10_1146_annurev_cellbio_092910_154020 crossref_primary_10_1016_j_actbio_2015_02_011 crossref_primary_10_3390_ijgi9080479 crossref_primary_10_1016_j_bbrc_2015_10_012 crossref_primary_10_1016_j_jacc_2014_05_021 crossref_primary_10_1016_j_stem_2016_04_013 crossref_primary_10_1016_j_jgg_2019_10_003 crossref_primary_10_1126_scitranslmed_aaa1805 crossref_primary_10_1016_j_bbrc_2023_03_024 crossref_primary_10_1002_0471140856_tx1413s67 crossref_primary_10_1371_journal_pone_0141688 crossref_primary_10_1016_j_stem_2016_10_019 crossref_primary_10_1002_jcp_24771 crossref_primary_10_1042_CBI20100766 crossref_primary_10_1182_blood_2014_06_585513 crossref_primary_10_1002_jbm_a_35122 crossref_primary_10_1016_j_stemcr_2016_01_010 crossref_primary_10_1016_j_envpol_2022_120849 crossref_primary_10_1016_j_stemcr_2013_11_007 crossref_primary_10_1016_j_omtm_2019_01_011 crossref_primary_10_1038_nature11807 crossref_primary_10_1002_biot_201100356 crossref_primary_10_1002_stem_700 crossref_primary_10_1016_j_tcb_2015_12_003 crossref_primary_10_1016_j_stem_2013_07_001 crossref_primary_10_1371_journal_pone_0154770 crossref_primary_10_3389_fcell_2024_1306530 crossref_primary_10_1111_j_1476_5381_2012_01857_x crossref_primary_10_1016_j_cell_2012_02_031 crossref_primary_10_1016_j_jcyt_2020_06_001 crossref_primary_10_1038_nrg3209 crossref_primary_10_1007_s12257_017_0221_1 crossref_primary_10_3724_SP_J_1206_2010_00333 crossref_primary_10_1038_msb_2011_84 crossref_primary_10_1038_mt_2012_273 crossref_primary_10_2217_fnl_11_14 crossref_primary_10_1089_scd_2018_0112 crossref_primary_10_1002_mrd_22797 crossref_primary_10_1002_stem_735 crossref_primary_10_1038_cr_2012_175 crossref_primary_10_1111_gtc_12227 crossref_primary_10_1161_HCG_0000000000000043 crossref_primary_10_1371_journal_pone_0085089 crossref_primary_10_1016_j_addr_2015_05_004 crossref_primary_10_1038_cr_2011_133 crossref_primary_10_1007_s00018_012_1139_6 crossref_primary_10_1093_cvr_cvt167 crossref_primary_10_1016_j_placenta_2022_10_011 crossref_primary_10_1142_S1568558612300028 crossref_primary_10_1038_srep00592 crossref_primary_10_3390_ijms17040530 crossref_primary_10_1016_j_jbiosc_2011_07_005 crossref_primary_10_1089_scd_2016_0156 crossref_primary_10_3389_fnagi_2014_00090 crossref_primary_10_2217_rme_11_6 crossref_primary_10_1007_s13238_013_0003_2 crossref_primary_10_1002_stem_1879 crossref_primary_10_1002_ajmg_a_36455 crossref_primary_10_1007_s11434_011_4436_9 crossref_primary_10_1038_cr_2012_157 crossref_primary_10_1182_bloodadvances_2018017137 crossref_primary_10_2485_jhtb_30_151 crossref_primary_10_1016_j_gde_2013_04_007 crossref_primary_10_1098_rsif_2012_0169 crossref_primary_10_1007_s13770_023_00557_6 crossref_primary_10_1155_2013_420164 crossref_primary_10_1242_jcs_084822 crossref_primary_10_1016_j_ejphar_2016_06_059 crossref_primary_10_1016_j_stem_2016_01_012 crossref_primary_10_3389_fimmu_2021_633436 crossref_primary_10_1038_nature10761 crossref_primary_10_1038_labinvest_2011_85 crossref_primary_10_1016_j_stem_2015_08_005 crossref_primary_10_1093_bfgp_elw017 crossref_primary_10_3389_fphar_2020_00396 crossref_primary_10_1089_cell_2014_0050 crossref_primary_10_3389_fncel_2020_00121 crossref_primary_10_1007_s12035_018_1232_4 crossref_primary_10_3390_cells10113250 crossref_primary_10_1126_science_1218071 crossref_primary_10_1016_j_stem_2013_11_006 crossref_primary_10_1038_mt_2010_237 crossref_primary_10_1089_scd_2011_0599 crossref_primary_10_1016_j_bbagen_2012_08_008 crossref_primary_10_1038_nbt_1805 crossref_primary_10_1093_humupd_dmx042 crossref_primary_10_1177_2050312120966456 crossref_primary_10_1007_s12265_010_9250_2 crossref_primary_10_1186_s13287_016_0466_1 crossref_primary_10_1186_1471_2164_15_978 crossref_primary_10_1111_j_1742_4658_2010_07926_x crossref_primary_10_1016_j_stem_2016_01_007 crossref_primary_10_1371_journal_pone_0027956 crossref_primary_10_1002_jcp_24509 crossref_primary_10_1016_j_celrep_2023_113664 crossref_primary_10_1016_j_jacc_2014_04_056 crossref_primary_10_1016_j_jaci_2014_08_038 crossref_primary_10_2217_rme_15_41 crossref_primary_10_1371_journal_pone_0024687 crossref_primary_10_1002_stem_531 crossref_primary_10_21307_ane_2020_024 crossref_primary_10_1016_j_trre_2016_02_001 crossref_primary_10_1007_s00018_012_1137_8 crossref_primary_10_1042_BJ20101707 crossref_primary_10_1111_j_1479_8301_2011_00394_x crossref_primary_10_1016_j_joca_2016_11_015 crossref_primary_10_1016_j_cell_2014_04_006 crossref_primary_10_1002_stem_765 crossref_primary_10_1016_j_semcdb_2012_06_010 crossref_primary_10_4061_2011_924782 crossref_primary_10_1002_stem_760 crossref_primary_10_1002_stem_1838 crossref_primary_10_1002_jcb_25027 crossref_primary_10_1016_j_gene_2012_11_016 crossref_primary_10_1002_dvdy_22553 crossref_primary_10_1038_ncb2239 crossref_primary_10_1371_journal_pbio_1001099 crossref_primary_10_1111_ane_12545 crossref_primary_10_1007_s12015_011_9318_7 crossref_primary_10_1016_j_ebiom_2019_03_011 crossref_primary_10_3390_biology1020175 crossref_primary_10_1152_physrev_00001_2023 crossref_primary_10_1182_blood_2011_06_357996 crossref_primary_10_1007_s00296_013_2704_5 crossref_primary_10_2220_biomedres_38_135 crossref_primary_10_1186_s12929_024_01035_4 crossref_primary_10_4252_wjsc_v11_i12_1020 crossref_primary_10_1038_mt_2012_207 crossref_primary_10_1016_j_febslet_2012_07_024 crossref_primary_10_1051_medsci_20102611902 crossref_primary_10_1161_CIRCRESAHA_111_249235 crossref_primary_10_1016_j_stemcr_2014_03_001 crossref_primary_10_1089_scd_2015_0117 crossref_primary_10_3390_ijms19113489 crossref_primary_10_1007_s10517_013_2096_2 crossref_primary_10_1002_msj_20233 crossref_primary_10_1155_2017_4378947 crossref_primary_10_1093_jmcb_mjr031 crossref_primary_10_1002_stem_788 crossref_primary_10_1210_me_2015_1290 crossref_primary_10_1016_j_diff_2014_02_004 crossref_primary_10_1016_j_cell_2013_02_043 crossref_primary_10_1016_j_ebiom_2020_102848 crossref_primary_10_1016_j_celrep_2013_06_015 crossref_primary_10_1002_ar_22793 crossref_primary_10_1038_cr_2013_173 crossref_primary_10_1155_2016_1816525 crossref_primary_10_1016_j_ddstr_2012_08_001 crossref_primary_10_1016_j_stem_2015_05_004 crossref_primary_10_1038_nature09798 crossref_primary_10_3389_fimmu_2023_1325209 crossref_primary_10_5115_acb_2011_44_4_245 crossref_primary_10_1038_icb_2015_5 crossref_primary_10_1089_scd_2011_0665 crossref_primary_10_1038_470013a crossref_primary_10_1016_j_copbio_2013_05_008 crossref_primary_10_1016_j_yexcr_2014_09_013 crossref_primary_10_1177_1535370214538588 crossref_primary_10_1262_jrd_11_112H crossref_primary_10_2174_1566523220999200818115803 crossref_primary_10_1039_C5TB02645H crossref_primary_10_1074_jbc_M113_538702 crossref_primary_10_1002_stem_3095 crossref_primary_10_3390_genes2010081 crossref_primary_10_1186_s13148_015_0112_2 crossref_primary_10_1016_j_bcmd_2012_12_001 crossref_primary_10_1016_j_jcyt_2015_01_003 crossref_primary_10_1371_journal_pone_0251054 crossref_primary_10_1038_nm_2504 crossref_primary_10_3858_emm_2012_44_3_015 crossref_primary_10_1007_s40496_013_0001_8 crossref_primary_10_1016_j_biopsych_2022_01_004 crossref_primary_10_1002_bies_201200088 crossref_primary_10_1042_BST20140031 crossref_primary_10_1002_cne_23820 crossref_primary_10_1002_stem_598 crossref_primary_10_1007_s00432_016_2258_5 crossref_primary_10_3390_ijms20215495 crossref_primary_10_1155_2020_1941629 crossref_primary_10_3390_jcm4040696 crossref_primary_10_12688_f1000research_18926_1 crossref_primary_10_1371_journal_pone_0106916 crossref_primary_10_1016_j_eururo_2013_06_015 crossref_primary_10_1016_j_scr_2012_12_004 crossref_primary_10_3390_cells12070977 crossref_primary_10_1038_mt_2012_245 crossref_primary_10_1186_s13287_015_0262_3 crossref_primary_10_3390_cells8050403 crossref_primary_10_1016_j_tcm_2012_03_003 crossref_primary_10_1371_journal_pone_0051711 crossref_primary_10_1007_s11626_020_00505_x crossref_primary_10_1073_pnas_1202352109 crossref_primary_10_1146_annurev_pathol_020117_043634 crossref_primary_10_1016_j_stemcr_2015_12_009 crossref_primary_10_1093_carcin_bgab042 crossref_primary_10_1007_s00018_012_0994_5 crossref_primary_10_1016_j_stemcr_2017_10_022 crossref_primary_10_3389_fcell_2019_00128 crossref_primary_10_1016_j_heares_2016_12_011 crossref_primary_10_1093_bfgp_elt011 crossref_primary_10_1038_s41380_019_0495_0 crossref_primary_10_1002_jcp_25437 crossref_primary_10_1016_j_diff_2015_12_003 crossref_primary_10_1038_ncb2748 crossref_primary_10_1038_s41467_022_33013_5 crossref_primary_10_1016_j_yjmcc_2011_07_014 crossref_primary_10_1111_j_1872_034X_2011_00896_x crossref_primary_10_1073_pnas_1111733108 crossref_primary_10_1177_1559325819876799 crossref_primary_10_1007_s12015_010_9204_8 crossref_primary_10_1016_j_ceb_2013_01_006 crossref_primary_10_1371_journal_pone_0019012 crossref_primary_10_1371_journal_pone_0072435 crossref_primary_10_1089_scd_2012_0157 crossref_primary_10_1016_j_stem_2015_07_021 crossref_primary_10_1182_blood_2010_07_298331 crossref_primary_10_1016_j_stem_2014_11_005 crossref_primary_10_2174_1574888X18666221223104859 crossref_primary_10_1161_CIRCRESAHA_111_243709 crossref_primary_10_1016_j_ymthe_2018_02_014 crossref_primary_10_1093_jmcb_mjr012 crossref_primary_10_1016_j_celrep_2020_108474 crossref_primary_10_1186_s13287_023_03305_8 crossref_primary_10_1038_nrm3036 crossref_primary_10_1186_gm252 crossref_primary_10_1038_d41586_023_02381_3 crossref_primary_10_1371_journal_pone_0171300 crossref_primary_10_1074_jbc_M110_183392 crossref_primary_10_1016_j_molmed_2013_11_004 crossref_primary_10_1274_jmor_30_68 crossref_primary_10_1038_s41586_023_06424_7 crossref_primary_10_1038_cdd_2014_132 crossref_primary_10_1002_stem_1066 crossref_primary_10_1016_j_celrep_2013_05_043 crossref_primary_10_1016_j_stem_2011_12_013 crossref_primary_10_3389_fimmu_2017_01935 crossref_primary_10_1186_1471_2202_14_130 crossref_primary_10_3390_ijms18010206 crossref_primary_10_1111_j_1600_0625_2011_01282_x crossref_primary_10_1038_nmeth_1707 crossref_primary_10_1007_s12015_014_9574_4 crossref_primary_10_1016_j_scr_2017_11_015 crossref_primary_10_1016_j_reactfunctpolym_2022_105233 crossref_primary_10_1089_ten_teb_2015_0559 crossref_primary_10_1016_j_stemcr_2015_11_007 crossref_primary_10_2217_rme_2016_0134 crossref_primary_10_1172_JCI82735 crossref_primary_10_1038_ncomms1503 crossref_primary_10_1038_s41598_017_18352_4 crossref_primary_10_1186_1479_5876_11_53 crossref_primary_10_1016_j_tig_2011_08_002 crossref_primary_10_1002_stem_1057 crossref_primary_10_1002_stem_1084 crossref_primary_10_1002_stem_3023 crossref_primary_10_1371_journal_pone_0136314 crossref_primary_10_3389_fcell_2021_748576 crossref_primary_10_1007_s12185_012_1095_9 crossref_primary_10_1016_j_nbd_2020_105174 crossref_primary_10_1016_j_scr_2020_101880 crossref_primary_10_1186_gm284 crossref_primary_10_1002_bies_201100174 crossref_primary_10_1002_stem_3029 crossref_primary_10_1016_j_jconrel_2014_12_031 crossref_primary_10_1002_0471142905_hg2102s87 crossref_primary_10_1002_stem_1074 crossref_primary_10_1002_stem_3256 crossref_primary_10_1016_S1878_3317_10_60033_2 crossref_primary_10_2217_rme_11_37 crossref_primary_10_5966_sctm_2012_0117 crossref_primary_10_1080_10408398_2024_2342480 crossref_primary_10_1038_nature10135 crossref_primary_10_3390_cells9112517 crossref_primary_10_5812_rijm_17803 crossref_primary_10_3390_biomedicines10051204 crossref_primary_10_1016_j_stemcr_2016_04_015 crossref_primary_10_1016_j_scr_2019_101489 crossref_primary_10_1016_j_beha_2010_09_017 crossref_primary_10_1186_s13023_018_0857_8 crossref_primary_10_1038_nrd3577 crossref_primary_10_3390_ijms25063214 crossref_primary_10_1161_CIRCGENETICS_113_000298 crossref_primary_10_3390_cells10092335 crossref_primary_10_1016_j_exger_2020_110870 crossref_primary_10_1016_j_msec_2016_08_019 crossref_primary_10_1007_s12015_011_9249_3 crossref_primary_10_1007_s12015_019_09900_8 crossref_primary_10_3390_cells9020420 crossref_primary_10_1016_j_yjmcc_2010_10_027 crossref_primary_10_1002_biot_201200202 crossref_primary_10_1186_scrt102 crossref_primary_10_1016_j_gene_2013_02_037 crossref_primary_10_1038_labinvest_2017_56 crossref_primary_10_1073_pnas_1016297108 crossref_primary_10_1007_s12015_013_9429_4 crossref_primary_10_1007_s12265_010_9235_1 crossref_primary_10_1080_10106049_2021_1987535 crossref_primary_10_1371_journal_pone_0193949 crossref_primary_10_1517_14712598_2014_920813 crossref_primary_10_1038_celldisc_2015_15 crossref_primary_10_1080_15384101_2016_1152425 crossref_primary_10_1002_jcp_24155 crossref_primary_10_3390_jcm3041357 crossref_primary_10_1371_journal_pone_0053771 crossref_primary_10_1007_s12265_012_9413_4 crossref_primary_10_1007_s12035_014_9084_z crossref_primary_10_1155_2014_182737 crossref_primary_10_1089_ten_teb_2023_0005 crossref_primary_10_1186_scrt33 crossref_primary_10_3389_fmed_2021_644594 crossref_primary_10_2217_epi_2016_0032 crossref_primary_10_3390_cancers12123581 |
| Cites_doi | 10.1126/science.1154884 10.1016/j.stem.2009.11.009 10.1038/ncb1674 10.1073/pnas.96.6.3120 10.1126/science.1087573 10.1093/bioinformatics/btn096 10.1038/nbt.1503 10.1016/j.stem.2008.08.003 10.1038/nature08320 10.1016/j.cell.2009.01.001 10.1016/j.cell.2008.03.028 10.1126/science.1151526 10.1182/blood-2009-02-204800 10.1038/nbt.1554 10.1038/nature05934 10.1016/j.cell.2004.10.021 10.1038/nature07056 10.1073/pnas.0507816102 10.1038/nature07677 10.1016/j.cell.2006.07.024 10.1016/j.cub.2008.05.010 10.1016/j.cell.2007.11.019 10.1016/j.stem.2008.12.010 10.1002/stem.321 10.1016/j.cell.2008.07.041 10.1016/j.stem.2008.05.011 10.1093/bioinformatics/bti394 10.1634/stemcells.2008-0317 10.1038/nature09017 10.1038/ng.428 10.1002/gcc.20243 10.1371/journal.pbio.0060253 10.1016/j.cell.2008.05.049 10.1242/jcs.054783 10.1016/j.cell.2006.02.041 10.1371/journal.pone.0008975 10.1007/978-1-59745-418-6_20 10.1016/j.stem.2008.02.001 10.1038/nature09342 10.1038/nmeth.1409 10.1073/pnas.0910012107 10.1016/j.cell.2009.02.013 10.1016/j.stem.2009.06.008 10.1038/nature07061 10.1101/gad.966002 10.1038/nprot.2008.211 10.1073/pnas.0711983105 10.1038/nbt1483 10.1073/pnas.0409813102 10.1038/nature06534 10.1126/science.1158799 10.1242/dev.00366 |
| ContentType | Journal Article |
| Copyright | 2015 INIST-CNRS COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Aug 2010 2010 Nature America, Inc. All rights reserved. 2010 |
| Copyright_xml | – notice: 2015 INIST-CNRS – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Aug 2010 – notice: 2010 Nature America, Inc. All rights reserved. 2010 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION N95 XI7 IOV ISR 3V. 7QO 7QP 7QR 7T7 7TK 7TM 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AFKRA AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH HCIFZ K9. L6V LK8 M0S M1P M2O M2P M7P M7S MBDVC P64 PQEST PQQKQ PQUKI PTHSS Q9U RC3 7X8 5PM |
| DOI | 10.1038/nbt.1667 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Gale Business Insights Business Insights: Essentials Gale In Context: Opposing Viewpoints database Science in Context ProQuest Central (Corporate) Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) ProQuest Engineering Collection Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest_Research Library Science Database (ProQuest) Biological Science Database Engineering Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Natural Science Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) Engineering Collection Engineering Database ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Technology Collection Technology Research Database ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Central Basic ProQuest Science Journals ProQuest SciTech Collection ProQuest Medical Library Materials Science & Engineering Collection ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Engineering Research Database Research Library Prep MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Engineering Biology |
| EISSN | 1546-1696 |
| EndPage | 855 |
| ExternalDocumentID | 2106591181 A621867784 10_1038_nbt_1667 20644536 23147048 nbt.1667 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: R37 HL056182 – fundername: NICHD NIH HHS grantid: R01 HD058013 – fundername: NIDDK NIH HHS grantid: P30DK036836 – fundername: NHLBI NIH HHS grantid: R37 HL056182-15 – fundername: NHLBI NIH HHS grantid: HL056182 – fundername: NIDDK NIH HHS grantid: P30 DK036836 – fundername: NIH HHS grantid: DP2 OD004345 – fundername: Howard Hughes Medical Institute – fundername: NHLBI NIH HHS grantid: R01 HL056182 – fundername: NIH HHS grantid: DP2 OD004345-01 – fundername: National Heart, Lung, and Blood Institute : NHLBI grantid: R37 HL056182-15 || HL |
| GroupedDBID | - 08R 0R 123 1AW 29M 2XV 39C 3V. 4.4 4R4 53G 55 5BI 5M7 5RE 5S5 70F 7X7 88A 88E 88I 8AO 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 A8Z AADWK AAEEF AAIKC AAPBV AAYJO AAYOK AAZLF ABAWZ ABDBF ABEFU ABFLS ABGIJ ABJCF ABOCM ABPTK ABUWG ACBTR ACGFS ACGOD ACIWK ACPRK ADBBV ADBIT ADQMX AEDAW AENEX AFDAS AFFNX AFKRA AFRAH AFSHS AGEZK AGHTU AHBCP AHGBK AHMBA AHSBF ALFFA ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC BAAKF BBAFP BBNVY BENPR BGLVJ BHPHI BKKNO BKOMP BPHCQ BVXVI C0K D1J DB5 DU5 DWQXO EAD EAP EAS EBC EBS EE. EJD EMB EMK ESX EXGXG F5P FA8 FEDTE FQGFK FSGXE FYUFA G8K GJ GNUQQ GUQSH GX1 HCIFZ HVGLF HZ IAG IAO IEA IEP IH2 IHR INH INR IOV IPNFZ ISR ITC KM KOO L6V LK8 M0L M1P M2O M2P M7P M7S ML0 MVM N95 NEJ NNMJJ O9- P2P PADUT PQEST PQQKQ PQUKI PRINS PROAC PSQYO PTHSS Q2X QF4 QM4 QN7 QO4 RIG RNS RNT RNTTT RVV RXW SHXYY SIXXV SJN SNYQT SV3 TAE TAOOD TBHMF TDRGL TN5 TSG TUS U5U X X7M XFK XHC XI7 Y6R YZZ ZA5 ZGI ZHY ZXP --- -~X .55 .GJ 0R~ 2FS 36B AADEA AAEXX AAJMP AAMNW AAUGY ABEEJ ABLJU ABVXF ACBMV ACBRV ACBYP ACGFO ACIGE ACTTH ACVWB ADFRT ADMDM ADZGE AEFTE AGAYW AGGBP AHOSX AIBTJ AJDOV AMTXH CCPQU EMOBN ESTFP HZ~ IQODW NYICJ UKHRP XOL ~KM AAHBH AARCD ABJNI ACMJI AFBBN ALIPV CGR CUY CVF ECM EIF HMCUK LGEZI LOTEE NADUK NPM NXXTH ODYON AAYXX CITATION AGPPL 7QO 7QP 7QR 7T7 7TK 7TM 7XB 8FD 8FK C1K FR3 K9. MBDVC P64 Q9U RC3 7X8 5PM |
| ID | FETCH-LOGICAL-c682t-e98967e3b49a8a75dfdacdc4636c5f8ebc2389bfcc4453ba92fa5bb48b8e21d63 |
| IEDL.DBID | 7X7 |
| ISSN | 1087-0156 |
| IngestDate | Tue Sep 17 21:14:39 EDT 2024 Fri Aug 16 02:11:22 EDT 2024 Thu Aug 15 22:31:55 EDT 2024 Sat Oct 05 14:35:47 EDT 2024 Thu Feb 22 23:53:33 EST 2024 Thu Aug 01 20:09:29 EDT 2024 Thu Aug 01 19:45:20 EDT 2024 Tue Oct 08 15:02:58 EDT 2024 Thu Sep 12 19:38:20 EDT 2024 Sat Sep 28 07:51:48 EDT 2024 Sun Oct 22 16:06:45 EDT 2023 Tue Jun 15 14:02:51 EDT 2021 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | Origin Transcription Rodentia Induced pluripotent stem cell Somatic cell Cell differentiation Gene expression In vitro Vertebrata Mammalia Mouse Epigenetics Methylation |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c682t-e98967e3b49a8a75dfdacdc4636c5f8ebc2389bfcc4453ba92fa5bb48b8e21d63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148605 |
| PMID | 20644536 |
| PQID | 741430387 |
| PQPubID | 47191 |
| PageCount | 8 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3148605 proquest_miscellaneous_874183829 proquest_miscellaneous_748929309 proquest_journals_741430387 gale_infotracmisc_A621867784 gale_incontextgauss_ISR_A621867784 gale_incontextgauss_IOV_A621867784 gale_businessinsightsgauss_A621867784 crossref_primary_10_1038_nbt_1667 pubmed_primary_20644536 pascalfrancis_primary_23147048 nature_primary_nbt_1667 |
| ProviderPackageCode | AEDAW AAZLF AADWK AAYJO 70F ADQMX EE. RNTTT RVV ABGIJ DB5 RNT AHGBK |
| PublicationCentury | 2000 |
| PublicationDate | 2010-08-01 |
| PublicationDateYYYYMMDD | 2010-08-01 |
| PublicationDate_xml | – month: 08 year: 2010 text: 2010-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States – name: New York |
| PublicationTitle | Nature biotechnology |
| PublicationTitleAlternate | Nat Biotechnol |
| PublicationYear | 2010 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| References | Bortvin, A. (b38) 2003; 130 Okita, K., Ichisaka, T., Yamanaka, S. (b21) 2007; 448 Eminli, S., Utikal, J., Arnold, K., Jaenisch, R., Hochedlinger, K. (b3) 2008; 26 Hanna, J. (b4) 2008; 133 Takahashi, K. (b8) 2007; 131 Thompson, R.F. (b50) 2008; 24 Maherali, N. (b13) 2008; 3 Mikkelsen, T.S. (b34) 2008; 454 Stadtfeld, M., Maherali, N., Breault, D.T., Hochedlinger, K. (b29) 2008; 2 Sridharan, R. (b35) 2009; 136 Selzer, R.R. (b49) 2005; 44 Culhane, A.C., Thioulouse, J., Perriere, G., Higgins, D.G. (b51) 2005; 21 Miura, K. (b18) 2009; 27 Boiani, M., Eckardt, S., Scholer, H.R., McLaughlin, K.J. (b37) 2002; 16 Conboy, I.M., Conboy, M.J., Smythe, G.M., Rando, T.A. (b44) 2003; 302 Ehrich, M. (b52) 2005; 102 Aoi, T. (b1) 2008; 321 Loh, Y.H. (b11) 2009; 113 Aasen, T. (b12) 2008; 26 Stadtfeld, M., Maherali, N., Borkent, M., Hochedlinger, K. (b31) 2010; 7 Cerletti, M. (b30) 2008; 134 Figueroa, M.E., Melnick, A., Greally, J.M. (b48) 2009; 538 Yu, J. (b10) 2007; 318 Lee, G. (b27) 2009; 461 Kim, K. (10.1038/nature09342 b43) 19 July 2010 Wernig, M. (b28) 2008; 26 Huang, D.W. (b47) 2009; 4 Silva, J. (b17) 2008; 6 Ng, R.K., Gurdon, J.B. (b40) 2008; 10 Dimos, J.T. (b23) 2008; 321 Sherwood, R.I. (b45) 2004; 119 Marion, R.M. (b36) 2009; 4 Lowry, W.E. (b5) 2008; 105 Cheshier, S.H., Morrison, S.J., Liao, X., Weissman, I.L. (b46) 1999; 96 Ng, R.K., Gurdon, J.B. (b39) 2005; 102 Stadtfeld, M., Brennand, K., Hochedlinger, K. (b7) 2008; 18 Park, I.H. (b6) 2008; 451 Soldner, F. (b20) 2009; 136 Eminli, S. (b2) 2009; 41 Takahashi, K., Yamanaka, S. (b9) 2006; 126 Park, I.H. (b25) 2008; 134 Stadtfeld, M. (b22) 2010; 465 Saha, K., Jaenisch, R. (b26) 2009; 5 Kim, J.B. (b15) 2008; 454 Bernstein, B.E. (b33) 2006; 125 Utikal, J., Maherali, N., Kulalert, W., Hochedlinger, K. (b14) 2009; 122 Ghosh, Z. (b19) 2010; 5 Chin, M.H. (b32) 2009; 5 Shi, Y. (b16) 2008; 2 Ebert, A.D. (b24) 2009; 457 Hu, B.Y. (b42) 2010; 107 Feng, Q. (b41) 2010; 28 18522845 - Cell Stem Cell. 2008 Jun 5;2(6):525-8 18669821 - Science. 2008 Aug 29;321(5893):1218-21 19570518 - Cell Stem Cell. 2009 Jul 2;5(1):111-23 20717148 - Nat Rev Mol Cell Biol. 2010 Sep;11(9):601 19693009 - Nature. 2009 Sep 17;461(7262):402-6 18594515 - Nature. 2008 Jul 31;454(7204):646-50 20155819 - Stem Cells. 2010 Apr;28(4):704-12 20126639 - PLoS One. 2010;5(2):e8975 20418860 - Nature. 2010 May 13;465(7295):175-81 18287077 - Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2883-8 19200803 - Cell Stem Cell. 2009 Feb 6;4(2):141-54 18942890 - PLoS Biol. 2008 Oct 21;6(10):e253 20644535 - Nature. 2010 Sep 16;467(7313):285-90 20010832 - Nat Methods. 2010 Jan;7(1):53-5 20717151 - Nat Rev Genet. 2010 Sep;11(9):593 18035408 - Cell. 2007 Nov 30;131(5):861-72 19723802 - J Cell Sci. 2009 Oct 1;122(Pt 19):3502-10 19299331 - Blood. 2009 May 28;113(22):5476-9 19167336 - Cell. 2009 Jan 23;136(2):364-77 19668214 - Nat Genet. 2009 Sep;41(9):968-76 15684086 - Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1957-62 19098894 - Nature. 2009 Jan 15;457(7227):277-80 18614009 - Cell. 2008 Jul 11;134(1):37-47 19269371 - Cell. 2009 Mar 6;136(5):964-77 16904174 - Cell. 2006 Aug 25;126(4):663-76 19951687 - Cell Stem Cell. 2009 Dec 4;5(6):584-95 18066050 - Nat Cell Biol. 2008 Jan;10(1):102-9 18423197 - Cell. 2008 Apr 18;133(2):250-64 18786420 - Cell Stem Cell. 2008 Sep 11;3(3):340-5 18931654 - Nat Biotechnol. 2008 Nov;26(11):1276-84 18691744 - Cell. 2008 Sep 5;134(5):877-86 18635867 - Stem Cells. 2008 Oct;26(10):2467-74 18501604 - Curr Biol. 2008 Jun 24;18(12):890-4 18371448 - Cell Stem Cell. 2008 Mar 6;2(3):230-40 16630819 - Cell. 2006 Apr 21;125(2):315-26 17554338 - Nature. 2007 Jul 19;448(7151):313-7 12023300 - Genes Dev. 2002 May 15;16(10):1209-19 18594521 - Nat Biotechnol. 2008 Aug;26(8):916-24 18509334 - Nature. 2008 Jul 3;454(7200):49-55 18157115 - Nature. 2008 Jan 10;451(7175):141-6 19590502 - Nat Biotechnol. 2009 Aug;27(8):743-5 18029452 - Science. 2007 Dec 21;318(5858):1917-20 20160098 - Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4335-40 12620990 - Development. 2003 Apr;130(8):1673-80 18276851 - Science. 2008 Aug 1;321(5889):699-702 J Utikal (BFnbt1667_CR14) 2009; 122 R Sridharan (BFnbt1667_CR35) 2009; 136 MH Chin (BFnbt1667_CR32) 2009; 5 Q Feng (BFnbt1667_CR41) 2010; 28 Z Ghosh (BFnbt1667_CR19) 2010; 5 M Boiani (BFnbt1667_CR37) 2002; 16 M Ehrich (BFnbt1667_CR52) 2005; 102 JT Dimos (BFnbt1667_CR23) 2008; 321 K Miura (BFnbt1667_CR18) 2009; 27 BFnbt1667_CR43 RI Sherwood (BFnbt1667_CR45) 2004; 119 ME Figueroa (BFnbt1667_CR48) 2009; 538 DW Huang (BFnbt1667_CR47) 2009; 4 JB Kim (BFnbt1667_CR15) 2008; 454 WE Lowry (BFnbt1667_CR5) 2008; 105 Y Shi (BFnbt1667_CR16) 2008; 2 RK Ng (BFnbt1667_CR40) 2008; 10 IH Park (BFnbt1667_CR25) 2008; 134 S Eminli (BFnbt1667_CR2) 2009; 41 M Stadtfeld (BFnbt1667_CR7) 2008; 18 A Bortvin (BFnbt1667_CR38) 2003; 130 T Aasen (BFnbt1667_CR12) 2008; 26 M Stadtfeld (BFnbt1667_CR22) 2010; 465 M Stadtfeld (BFnbt1667_CR31) 2010; 7 RK Ng (BFnbt1667_CR39) 2005; 102 J Yu (BFnbt1667_CR10) 2007; 318 G Lee (BFnbt1667_CR27) 2009; 461 RR Selzer (BFnbt1667_CR49) 2005; 44 IM Conboy (BFnbt1667_CR44) 2003; 302 RF Thompson (BFnbt1667_CR50) 2008; 24 F Soldner (BFnbt1667_CR20) 2009; 136 BY Hu (BFnbt1667_CR42) 2010; 107 T Aoi (BFnbt1667_CR1) 2008; 321 S Eminli (BFnbt1667_CR3) 2008; 26 K Takahashi (BFnbt1667_CR8) 2007; 131 IH Park (BFnbt1667_CR6) 2008; 451 RM Marion (BFnbt1667_CR36) 2009; 4 AC Culhane (BFnbt1667_CR51) 2005; 21 SH Cheshier (BFnbt1667_CR46) 1999; 96 TS Mikkelsen (BFnbt1667_CR34) 2008; 454 N Maherali (BFnbt1667_CR13) 2008; 3 K Takahashi (BFnbt1667_CR9) 2006; 126 K Saha (BFnbt1667_CR26) 2009; 5 BE Bernstein (BFnbt1667_CR33) 2006; 125 J Silva (BFnbt1667_CR17) 2008; 6 AD Ebert (BFnbt1667_CR24) 2009; 457 YH Loh (BFnbt1667_CR11) 2009; 113 M Stadtfeld (BFnbt1667_CR29) 2008; 2 J Hanna (BFnbt1667_CR4) 2008; 133 K Okita (BFnbt1667_CR21) 2007; 448 M Cerletti (BFnbt1667_CR30) 2008; 134 M Wernig (BFnbt1667_CR28) 2008; 26 |
| References_xml | – volume: 451 start-page: 141 year: 2008 end-page: 146 ident: b6 publication-title: Nature contributor: fullname: Park, I.H. – volume: 102 start-page: 15785 year: 2005 end-page: 15790 ident: b52 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Ehrich, M. – volume: 125 start-page: 315 year: 2006 end-page: 326 ident: b33 publication-title: Cell contributor: fullname: Bernstein, B.E. – volume: 41 start-page: 968 year: 2009 end-page: 976 ident: b2 publication-title: Nat. Genet. contributor: fullname: Eminli, S. – volume: 21 start-page: 2789 year: 2005 end-page: 2790 ident: b51 publication-title: Bioinformatics contributor: fullname: Higgins, D.G. – volume: 119 start-page: 543 year: 2004 end-page: 554 ident: b45 publication-title: Cell contributor: fullname: Sherwood, R.I. – volume: 321 start-page: 699 year: 2008 end-page: 702 ident: b1 publication-title: Science contributor: fullname: Aoi, T. – volume: 16 start-page: 1209 year: 2002 end-page: 1219 ident: b37 publication-title: Genes Dev. contributor: fullname: McLaughlin, K.J. – volume: 6 start-page: e253 year: 2008 ident: b17 publication-title: PLoS Biol. contributor: fullname: Silva, J. – volume: 7 start-page: 53 year: 2010 end-page: 55 ident: b31 publication-title: Nat. Methods contributor: fullname: Hochedlinger, K. – volume: 131 start-page: 861 year: 2007 end-page: 872 ident: b8 publication-title: Cell contributor: fullname: Takahashi, K. – volume: 18 start-page: 890 year: 2008 end-page: 894 ident: b7 publication-title: Curr. Biol. contributor: fullname: Hochedlinger, K. – volume: 10 start-page: 102 year: 2008 end-page: 109 ident: b40 publication-title: Nat. Cell Biol. contributor: fullname: Gurdon, J.B. – volume: 136 start-page: 364 year: 2009 end-page: 377 ident: b35 publication-title: Cell contributor: fullname: Sridharan, R. – volume: 133 start-page: 250 year: 2008 end-page: 264 ident: b4 publication-title: Cell contributor: fullname: Hanna, J. – volume: 26 start-page: 1276 year: 2008 end-page: 1284 ident: b12 publication-title: Nat. Biotechnol. contributor: fullname: Aasen, T. – volume: 105 start-page: 2883 year: 2008 end-page: 2888 ident: b5 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Lowry, W.E. – volume: 96 start-page: 3120 year: 1999 end-page: 3125 ident: b46 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Weissman, I.L. – volume: 130 start-page: 1673 year: 2003 end-page: 1680 ident: b38 publication-title: Development contributor: fullname: Bortvin, A. – volume: 26 start-page: 2467 year: 2008 end-page: 2474 ident: b3 publication-title: Stem Cells contributor: fullname: Hochedlinger, K. – year: 19 July 2010 ident: 10.1038/nature09342 b43 publication-title: Nature contributor: fullname: Kim, K. – volume: 113 start-page: 5476 year: 2009 end-page: 5479 ident: b11 publication-title: Blood contributor: fullname: Loh, Y.H. – volume: 4 start-page: 44 year: 2009 end-page: 57 ident: b47 publication-title: Nat. Protoc. contributor: fullname: Huang, D.W. – volume: 102 start-page: 1957 year: 2005 end-page: 1962 ident: b39 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Gurdon, J.B. – volume: 28 start-page: 704 year: 2010 end-page: 712 ident: b41 publication-title: Stem Cells contributor: fullname: Feng, Q. – volume: 5 start-page: e8975 year: 2010 ident: b19 publication-title: PLoS One contributor: fullname: Ghosh, Z. – volume: 5 start-page: 584 year: 2009 end-page: 595 ident: b26 publication-title: Cell Stem Cell contributor: fullname: Jaenisch, R. – volume: 538 start-page: 395 year: 2009 end-page: 407 ident: b48 publication-title: Methods Mol. Biol. contributor: fullname: Greally, J.M. – volume: 454 start-page: 49 year: 2008 end-page: 55 ident: b34 publication-title: Nature contributor: fullname: Mikkelsen, T.S. – volume: 3 start-page: 340 year: 2008 end-page: 345 ident: b13 publication-title: Cell Stem Cell contributor: fullname: Maherali, N. – volume: 134 start-page: 877 year: 2008 end-page: 886 ident: b25 publication-title: Cell contributor: fullname: Park, I.H. – volume: 126 start-page: 663 year: 2006 end-page: 676 ident: b9 publication-title: Cell contributor: fullname: Yamanaka, S. – volume: 44 start-page: 305 year: 2005 end-page: 319 ident: b49 publication-title: Genes Chromosom. Cancer contributor: fullname: Selzer, R.R. – volume: 302 start-page: 1575 year: 2003 end-page: 1577 ident: b44 publication-title: Science contributor: fullname: Rando, T.A. – volume: 134 start-page: 37 year: 2008 end-page: 47 ident: b30 publication-title: Cell contributor: fullname: Cerletti, M. – volume: 454 start-page: 646 year: 2008 end-page: 650 ident: b15 publication-title: Nature contributor: fullname: Kim, J.B. – volume: 321 start-page: 1218 year: 2008 end-page: 1221 ident: b23 publication-title: Science contributor: fullname: Dimos, J.T. – volume: 2 start-page: 525 year: 2008 end-page: 528 ident: b16 publication-title: Cell Stem Cell contributor: fullname: Shi, Y. – volume: 107 start-page: 4335 year: 2010 end-page: 4340 ident: b42 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Hu, B.Y. – volume: 2 start-page: 230 year: 2008 end-page: 240 ident: b29 publication-title: Cell Stem Cell contributor: fullname: Hochedlinger, K. – volume: 27 start-page: 743 year: 2009 end-page: 745 ident: b18 publication-title: Nat. Biotechnol. contributor: fullname: Miura, K. – volume: 4 start-page: 141 year: 2009 end-page: 154 ident: b36 publication-title: Cell Stem Cell contributor: fullname: Marion, R.M. – volume: 24 start-page: 1161 year: 2008 end-page: 1167 ident: b50 publication-title: Bioinformatics contributor: fullname: Thompson, R.F. – volume: 461 start-page: 402 year: 2009 end-page: 406 ident: b27 publication-title: Nature contributor: fullname: Lee, G. – volume: 465 start-page: 175 year: 2010 end-page: 181 ident: b22 publication-title: Nature contributor: fullname: Stadtfeld, M. – volume: 457 start-page: 277 year: 2009 end-page: 280 ident: b24 publication-title: Nature contributor: fullname: Ebert, A.D. – volume: 122 start-page: 3502 year: 2009 end-page: 3510 ident: b14 publication-title: J. Cell Sci. contributor: fullname: Hochedlinger, K. – volume: 318 start-page: 1917 year: 2007 end-page: 1920 ident: b10 publication-title: Science contributor: fullname: Yu, J. – volume: 136 start-page: 964 year: 2009 end-page: 977 ident: b20 publication-title: Cell contributor: fullname: Soldner, F. – volume: 448 start-page: 313 year: 2007 end-page: 317 ident: b21 publication-title: Nature contributor: fullname: Yamanaka, S. – volume: 5 start-page: 111 year: 2009 end-page: 123 ident: b32 publication-title: Cell Stem Cell contributor: fullname: Chin, M.H. – volume: 26 start-page: 916 year: 2008 end-page: 924 ident: b28 publication-title: Nat. Biotechnol. contributor: fullname: Wernig, M. – volume: 321 start-page: 699 year: 2008 ident: BFnbt1667_CR1 publication-title: Science doi: 10.1126/science.1154884 contributor: fullname: T Aoi – volume: 5 start-page: 584 year: 2009 ident: BFnbt1667_CR26 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.11.009 contributor: fullname: K Saha – volume: 10 start-page: 102 year: 2008 ident: BFnbt1667_CR40 publication-title: Nat. Cell Biol. doi: 10.1038/ncb1674 contributor: fullname: RK Ng – volume: 96 start-page: 3120 year: 1999 ident: BFnbt1667_CR46 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.96.6.3120 contributor: fullname: SH Cheshier – volume: 302 start-page: 1575 year: 2003 ident: BFnbt1667_CR44 publication-title: Science doi: 10.1126/science.1087573 contributor: fullname: IM Conboy – volume: 24 start-page: 1161 year: 2008 ident: BFnbt1667_CR50 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn096 contributor: fullname: RF Thompson – volume: 26 start-page: 1276 year: 2008 ident: BFnbt1667_CR12 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1503 contributor: fullname: T Aasen – volume: 3 start-page: 340 year: 2008 ident: BFnbt1667_CR13 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.08.003 contributor: fullname: N Maherali – volume: 461 start-page: 402 year: 2009 ident: BFnbt1667_CR27 publication-title: Nature doi: 10.1038/nature08320 contributor: fullname: G Lee – volume: 136 start-page: 364 year: 2009 ident: BFnbt1667_CR35 publication-title: Cell doi: 10.1016/j.cell.2009.01.001 contributor: fullname: R Sridharan – volume: 133 start-page: 250 year: 2008 ident: BFnbt1667_CR4 publication-title: Cell doi: 10.1016/j.cell.2008.03.028 contributor: fullname: J Hanna – volume: 318 start-page: 1917 year: 2007 ident: BFnbt1667_CR10 publication-title: Science doi: 10.1126/science.1151526 contributor: fullname: J Yu – volume: 113 start-page: 5476 year: 2009 ident: BFnbt1667_CR11 publication-title: Blood doi: 10.1182/blood-2009-02-204800 contributor: fullname: YH Loh – volume: 27 start-page: 743 year: 2009 ident: BFnbt1667_CR18 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1554 contributor: fullname: K Miura – volume: 448 start-page: 313 year: 2007 ident: BFnbt1667_CR21 publication-title: Nature doi: 10.1038/nature05934 contributor: fullname: K Okita – volume: 119 start-page: 543 year: 2004 ident: BFnbt1667_CR45 publication-title: Cell doi: 10.1016/j.cell.2004.10.021 contributor: fullname: RI Sherwood – volume: 454 start-page: 49 year: 2008 ident: BFnbt1667_CR34 publication-title: Nature doi: 10.1038/nature07056 contributor: fullname: TS Mikkelsen – volume: 102 start-page: 15785 year: 2005 ident: BFnbt1667_CR52 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0507816102 contributor: fullname: M Ehrich – volume: 457 start-page: 277 year: 2009 ident: BFnbt1667_CR24 publication-title: Nature doi: 10.1038/nature07677 contributor: fullname: AD Ebert – volume: 126 start-page: 663 year: 2006 ident: BFnbt1667_CR9 publication-title: Cell doi: 10.1016/j.cell.2006.07.024 contributor: fullname: K Takahashi – volume: 18 start-page: 890 year: 2008 ident: BFnbt1667_CR7 publication-title: Curr. Biol. doi: 10.1016/j.cub.2008.05.010 contributor: fullname: M Stadtfeld – volume: 131 start-page: 861 year: 2007 ident: BFnbt1667_CR8 publication-title: Cell doi: 10.1016/j.cell.2007.11.019 contributor: fullname: K Takahashi – volume: 4 start-page: 141 year: 2009 ident: BFnbt1667_CR36 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.12.010 contributor: fullname: RM Marion – volume: 28 start-page: 704 year: 2010 ident: BFnbt1667_CR41 publication-title: Stem Cells doi: 10.1002/stem.321 contributor: fullname: Q Feng – volume: 134 start-page: 877 year: 2008 ident: BFnbt1667_CR25 publication-title: Cell doi: 10.1016/j.cell.2008.07.041 contributor: fullname: IH Park – volume: 2 start-page: 525 year: 2008 ident: BFnbt1667_CR16 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.05.011 contributor: fullname: Y Shi – volume: 21 start-page: 2789 year: 2005 ident: BFnbt1667_CR51 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti394 contributor: fullname: AC Culhane – volume: 26 start-page: 2467 year: 2008 ident: BFnbt1667_CR3 publication-title: Stem Cells doi: 10.1634/stemcells.2008-0317 contributor: fullname: S Eminli – volume: 465 start-page: 175 year: 2010 ident: BFnbt1667_CR22 publication-title: Nature doi: 10.1038/nature09017 contributor: fullname: M Stadtfeld – volume: 41 start-page: 968 year: 2009 ident: BFnbt1667_CR2 publication-title: Nat. Genet. doi: 10.1038/ng.428 contributor: fullname: S Eminli – volume: 44 start-page: 305 year: 2005 ident: BFnbt1667_CR49 publication-title: Genes Chromosom. Cancer doi: 10.1002/gcc.20243 contributor: fullname: RR Selzer – volume: 6 start-page: e253 year: 2008 ident: BFnbt1667_CR17 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0060253 contributor: fullname: J Silva – volume: 134 start-page: 37 year: 2008 ident: BFnbt1667_CR30 publication-title: Cell doi: 10.1016/j.cell.2008.05.049 contributor: fullname: M Cerletti – volume: 122 start-page: 3502 year: 2009 ident: BFnbt1667_CR14 publication-title: J. Cell Sci. doi: 10.1242/jcs.054783 contributor: fullname: J Utikal – volume: 125 start-page: 315 year: 2006 ident: BFnbt1667_CR33 publication-title: Cell doi: 10.1016/j.cell.2006.02.041 contributor: fullname: BE Bernstein – volume: 5 start-page: e8975 year: 2010 ident: BFnbt1667_CR19 publication-title: PLoS One doi: 10.1371/journal.pone.0008975 contributor: fullname: Z Ghosh – volume: 538 start-page: 395 year: 2009 ident: BFnbt1667_CR48 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-59745-418-6_20 contributor: fullname: ME Figueroa – volume: 2 start-page: 230 year: 2008 ident: BFnbt1667_CR29 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.02.001 contributor: fullname: M Stadtfeld – ident: BFnbt1667_CR43 doi: 10.1038/nature09342 – volume: 7 start-page: 53 year: 2010 ident: BFnbt1667_CR31 publication-title: Nat. Methods doi: 10.1038/nmeth.1409 contributor: fullname: M Stadtfeld – volume: 107 start-page: 4335 year: 2010 ident: BFnbt1667_CR42 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0910012107 contributor: fullname: BY Hu – volume: 136 start-page: 964 year: 2009 ident: BFnbt1667_CR20 publication-title: Cell doi: 10.1016/j.cell.2009.02.013 contributor: fullname: F Soldner – volume: 5 start-page: 111 year: 2009 ident: BFnbt1667_CR32 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.06.008 contributor: fullname: MH Chin – volume: 454 start-page: 646 year: 2008 ident: BFnbt1667_CR15 publication-title: Nature doi: 10.1038/nature07061 contributor: fullname: JB Kim – volume: 16 start-page: 1209 year: 2002 ident: BFnbt1667_CR37 publication-title: Genes Dev. doi: 10.1101/gad.966002 contributor: fullname: M Boiani – volume: 4 start-page: 44 year: 2009 ident: BFnbt1667_CR47 publication-title: Nat. Protoc. doi: 10.1038/nprot.2008.211 contributor: fullname: DW Huang – volume: 105 start-page: 2883 year: 2008 ident: BFnbt1667_CR5 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0711983105 contributor: fullname: WE Lowry – volume: 26 start-page: 916 year: 2008 ident: BFnbt1667_CR28 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1483 contributor: fullname: M Wernig – volume: 102 start-page: 1957 year: 2005 ident: BFnbt1667_CR39 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0409813102 contributor: fullname: RK Ng – volume: 451 start-page: 141 year: 2008 ident: BFnbt1667_CR6 publication-title: Nature doi: 10.1038/nature06534 contributor: fullname: IH Park – volume: 321 start-page: 1218 year: 2008 ident: BFnbt1667_CR23 publication-title: Science doi: 10.1126/science.1158799 contributor: fullname: JT Dimos – volume: 130 start-page: 1673 year: 2003 ident: BFnbt1667_CR38 publication-title: Development doi: 10.1242/dev.00366 contributor: fullname: A Bortvin |
| SSID | ssj0006466 |
| Score | 2.608974 |
| Snippet | Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains... Polo et al. show that early-passage induced pluripotent stem cells retain an epigenetic memory of their cell type of origin. These epigenetic differences... |
| SourceID | pubmedcentral proquest gale crossref pubmed pascalfrancis nature |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 848 |
| SubjectTerms | Analysis Animals B cells B-Lymphocytes - cytology Biological and medical sciences Biotechnology Cell Differentiation Cell Lineage Cells, Cultured Diseases Embryoid Bodies - cytology Embryoid Bodies - metabolism Epigenetic inheritance Epigenomics Fibroblasts - cytology Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genes Health. Pharmaceutical industry Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Industrial applications and implications. Economical aspects Mice Miscellaneous Molecular biology Muscle, Skeletal - cytology Polo Rodents Stem cells Stem Cells - cytology Transcription, Genetic |
| Title | Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells |
| URI | http://dx.doi.org/10.1038/nbt.1667 https://www.ncbi.nlm.nih.gov/pubmed/20644536 https://www.proquest.com/docview/741430387/abstract/ https://search.proquest.com/docview/748929309 https://search.proquest.com/docview/874183829 https://pubmed.ncbi.nlm.nih.gov/PMC3148605 |
| Volume | 28 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwED6NTSAQQlBghI3KIHgMXRLHcZ7QmNYOpA00GOpbZMc2TCpJWdIH_nvu8qsrAsRLpMoXxcqd7y531-8DeBm42DgXCz9W1vk8UKmvIyN94XRKcFnCNqXs0zNxcsHfz-P5Fsz6_8LQWGXvExtHbcqcauQTjHw8ol7rRGkqAuT15M3yh0_0UdRm7bg0bsBOEGJWgYadzIcvLwy7TdMyOJA0ZxmLHoU2kpNC168D0dDMr-NS550HcM27S1XhK3Mt18WfktHfZyqvBanpfbjXZZfssDWHB7BlixHcbPkmf47gzjX0wRHcOu366g-hOLKLBaNyLCsda8my2GXPX1IxzBLZ955Il6nCMIqHbRmRLamef0XArHQzlRIs3mvQZgxbLlbolUpMzGtGkNGMGgXVI7iYHn8-OvE7JgY_FzKsfZvKVCQ20jxVUiWoXqNykxPYWB47aXWOkT_VLs85jyOt0tCpWGsutbRhYET0GLaLsrBPgBGAGNcmcDrHr3Idpk4KwjTjziRpYKQHz3s9ZMsWcCNrGuWRzFBXGenKg1ekoKzj6cRLRZWM6qtaVVV2KMIGpU9yD140coRzUdAgTSvw7sOX_xD6dL4htN8JuZKMD89gvrG825rKsOX1VscbtjMIYF7NE3SfHuz1xpR17qPKBmP3gA2r9EyaiCssKjIj1CBM1Q7Sv4tIQiaKZIgiu61xrp-ORwI1JTxINsx2ECDU8c2V4vJbgz6O-5b4Dfz0n_veg9vtmAVNSu7Ddn21ss8we6v1uDmZeJXT2Rh23h6ffTzHX7N58AvgdUsX |
| link.rule.ids | 230,315,786,790,891,12083,12792,21416,27957,27958,31754,31755,33408,33409,33779,33780,43345,43635,43840,74102,74392,74659 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9NADLegE19CCAqMsDEOBI9hS3K5Xp7QmDZ1sBY0NrS3KPe1TSppWdoH_nvsXJKuCBAveTlHOcU-22dbvx_Am8ilxrlUhGlhXcijIgtVYmQonMoILkvYupQ9GovhKf94lp41szlVM1bZ-sTaUZupphr5NkY-nlCv9f3sR0ikUdRcbRg0bsIaT_Cm0oO1D_vjL8edKxa-WRntSJqvTEWLPpvI7VLN30WippdfxqPGK3egmvdnRYW_ynmOiz8lob_PUl4LTgcP4UGTVbJdbwaP4IYt-3DL80z-7MO9a6iDfbg9avrpj6Hcs5MJozIsmzrmSbLYZctbUjHMDtn3lkCXFaVhFAd9-ZDNqI5_RYCs9DKVECy-a9BWDJtNFuiNppiQzxlBRTNqEFRP4PRg_2RvGDYMDKEWMp6HNpOZGNhE8ayQxQDVagptNIGM6dRJqzRG_Ew5rTlPE1VksStSpbhU0saREclT6JXT0j4DRsBhXJnIKY23cRVnTgrCMuPODLLIyABetXrIZx5oI68b5InMUVc56SqAt6SgvOHnxEdFFYzqvFhUVb4r4hqdT_IAXtdyhG9R0gCNFzj8_O0_hL4erwhtNkJuiurVePb0yvK6N5Vuy8utbq3YTieA-TQfoNsMYKM1prxxG1XeGXkArFulb9IkXGlRkTmhBWGKtpP9XUQSIlEiYxRZ98a5_DoeCdSUCGCwYradAKGNr66Ulxc16jjuW-Ld9_k_9_0S7gxPRkf50eH40wbc9aMWNC25Cb351cK-wAxurraac_oL2-RIPw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9QwDLZgiAmEEBwwysYICB7LrW2aS5_QNDg2YAMBQ3urml9s0q13rHcP_PfYTdrbIUC89CWOGtWO7drW9wE8T1xunMtFnFfWxTypilhlRsbCqYLgsoRtS9mHR2L_mL87yU8CpFATxio7n9g6ajPVVCMfYuTjGfVahy5MRXx6PX41-xETgRQ1WgObxlW4Rjk2kRnI8dveKQvftkx2JE1a5qLDoc3ksFbzl4loieaXkSn45x5e89asavCjOc928ad09PepykthanwHbof8ku16g7gLV2w9gOuecfLnAG5ewh8cwPph6Kzfg3rPTiaMCrJs6piny2JnHYNJwzBPZOcdlS6rasMoIvpCIptRRf-CoFlpMxUTLO41aDWGzSYL9EtTTM3njECjGbUKmvtwPH7zdW8_DlwMsRYynce2kIUY2UzxopLVCBVsKm00wY3p3EmrNMb-QjmtOc8zVRWpq3KluFTSpokR2QNYq6e1fQiMIMS4MolTGv_LVVo4KQjVjDszKhIjI3ja6aGceciNsm2VZ7JEXZWkqwhekILKwNSJj4ZqGc33atE05a5IW5w-ySN41soR0kVNRuMFDj5--w-hL59XhLaCkJuiejXeQr2yvOFNpT_y8qjbK7bTC2BmzUfoQCPY7IypDA6kKXtzj4D1q_ROmomrLSqyJNwgTNZ2ir-LSMImymSKIhveOJdvxyuBmhIRjFbMthcg3PHVlfrstMUfx3NL_At-9M9zP4F1vKDlh4Oj95tww89c0NjkFqzNLxb2MaZyc7XdXtJfz0xLDg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cell+type+of+origin+influences+the+molecular+and+functional+properties+of+mouse+induced+pluripotent+stem+cells&rft.jtitle=Nature+biotechnology&rft.au=POLO%2C+Jose+M&rft.au=LIU%2C+Susanna&rft.au=NATESAN%2C+Sridaran&rft.au=WAGERS%2C+Amy+J&rft.date=2010-08-01&rft.pub=Nature+Publishing+Group&rft.issn=1087-0156&rft.eissn=1546-1696&rft.volume=28&rft.issue=8&rft.spage=848&rft.epage=855&rft_id=info:doi/10.1038%2Fnbt.1667&rft.externalDBID=n%2Fa&rft.externalDocID=23147048 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1087-0156&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1087-0156&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1087-0156&client=summon |