Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

• Published in: Diabetes (New York, N.Y.) Vol. 57; no. 11; pp. 2943 - 2949
• Main Authors: Phielix, Esther, Schrauwen-Hinderling, Vera B., Mensink, Marco, Lenaers, Ellen, Meex, Ruth, Hoeks, Joris, Kooi, Marianne Eline, Moonen-Kornips, Esther, Sels, Jean-Pierre, Hesselink, Matthijs K.C., Schrauwen, Patrick
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.11.2008
• Subjects: Adenosine Diphosphate - metabolism; Age; Biological and medical sciences; Carbohydrate Metabolism - drug effects; Cell Respiration - physiology; Complications and side effects; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise; Glucose; Glucose - metabolism; Health aspects; Humans; Insulin - pharmacology; Insulin resistance; Lipid Metabolism - drug effects; Lipids; Male; Medical sciences; Metabolism; Methods; Middle Aged; Mitochondria, Muscle - drug effects; Mitochondria, Muscle - metabolism; Muscle cells; Musculoskeletal system; Physical fitness; Research design; Respiration; Spectrum analysis; Type 2 diabetes; United States; Endocrinopathy; Type 2 diabetes; Human; In vivo; Mitochondria; Dysfunction; Metabolic diseases; Male; Muscle; Respiration; ADP

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients Esther Phielix 1 , Vera B. Schrauwen-Hinderling 1 2 , Marco Mensink 1 , Ellen Lenaers 3 , Ruth Meex 3 , Joris Hoeks 1 , Marianne Eline Kooi 2 , Esther Moone...