MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis

• Published in: Oncogene Vol. 33; no. 36; pp. 4496 - 4507
• Main Authors: Chan, S-H, Huang, W-C, Chang, J-W, Chang, K-J, Kuo, W-H, Wang, M-Y, Lin, K-Y, Uen, Y-H, Hou, M-F, Lin, C-M, Jang, T-H, Tu, C-W, Lee, Y-R, Lee, Y-H, Tien, M-T, Wang, L-H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.09.2014; Nature Publishing Group
• Subjects: 631/337/384/331; 631/80/86; 692/699/67/1347; 692/699/67/322; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Apoptosis; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell adhesion & migration; Cell Biology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Development and progression; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genetic aspects; Human Genetics; Humans; Integrins; Integrins - genetics; Integrins - metabolism; Internal Medicine; Medicine; Medicine & Public Health; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplasm Invasiveness - pathology; Neoplasm Metastasis - pathology; Oncology; Original; original-article; Properties; Signal Transduction; Tumor Cells, Cultured

Metastasis is the predominant cause of death in breast cancer patients. Several lines of evidence have shown that microRNAs (miRs) can have an important role in cancer metastasis. Using isogenic pairs of low and high metastatic lines derived from a human breast cancer line, we have identified miR-14...