Human keratinocyte-derived extracellular vesicles activate the MAPKinase pathway and promote cell migration and proliferation in vitro

• Published in: Inflammation and Regeneration Vol. 41; no. 1; pp. 4 - 9
• Main Authors: Glady, Azela, Vandebroek, Arno, Yasui, Masato
• Format: Journal Article
• Language: English
• Published: England BioMed Central 02.02.2021; BMC
• Subjects: Antibodies; Cell adhesion & migration; Cell growth; Cell migration; Cytokines; Extracellular vesicle; Extracellular vesicles; Fibroblast; Fibroblasts; Growth factors; Infections; Keratinocyte; Kinases; MAPKinase; Proteins; Skin; Software; Statistical analysis; Stem cells; Wound healing; Wound healing; P38; MAPKinase; Keratinocyte; Extracellular vesicle; Fibroblast; Cell migration; ERK

Wound healing is a complex biological process and complete skin regeneration is still a critical challenge. Extracellular vesicles (EVs) play essential roles in cell communication and cell regeneration, and recent studies have suggested that EVs may contribute to wound healing, though the molecular...