The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory

• Published in: Nature immunology Vol. 16; no. 10; pp. 1034 - 1043
• Main Authors: Yoshida, Keisuke, Maekawa, Toshio, Zhu, Yujuan, Renard-Guillet, Claire, Chatton, Bruno, Inoue, Kentaro, Uchiyama, Takeru, Ishibashi, Ken-ichi, Yamada, Takuji, Ohno, Naohito, Shirahige, Katsuhiko, Okada-Hatakeyama, Mariko, Ishii, Shunsuke
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2015; Nature Publishing Group
• Subjects: 45; 45/15; 45/61; 631/250/2502/2170; 64; 64/60; 692/699/249/2510/9; Activating Transcription Factors - genetics; Activating Transcription Factors - metabolism; Animals; Bacterial diseases; Biomedicine; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - immunology; Genetic aspects; Growth; Health aspects; Immune response; Immune system; Immunologic Memory - genetics; Immunologic Memory - immunology; Immunology; Infectious Diseases; Lipopolysaccharides - pharmacology; Lymphocytes; Macrophages; Macrophages - immunology; Mice; Reverse Transcriptase Polymerase Chain Reaction; Transcription factors

The role of the stress-induced transcription factor ATF7 in immunity is largely unknown. Ishii and colleagues show that ATF7 represses select innate immunity–related genes, but activity is downregulated during the induction of macrophage memory. Immunological memory is thought to be mediated exclusi...