Molecular mechanisms of cancer cachexia‐related loss of skeletal muscle mass: data analysis from preclinical and clinical studies

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 14; no. 3; pp. 1150 - 1167
• Main Authors: Martin, Agnès, Gallot, Yann S., Freyssenet, Damien
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.06.2023; Wiley Open Access/Springer Verlag; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Apoptosis; Autophagy–lysosome; Cachexia - metabolism; Cancer; Cancer cachexia; Data Analysis; Enzymes; Glucocorticoids; Humans; Inflammation; Life Sciences; Muscle, Skeletal - metabolism; Musculoskeletal system; Myostatin; Myostatin - metabolism; Neoplasms - complications; Neoplasms - metabolism; Oxidative stress; Proteasome Endopeptidase Complex - metabolism; Protein synthesis; Proteins; Proteostasis; Quality of Life; Review; Reviews; Skeletal muscle; Ubiquitins - metabolism; Ubiquitins - pharmacology; Ubiquitins - therapeutic use; Ubiquitin–proteasome; Oxidative stress; Cancer cachexia; Autophagy-lysosome; Proteostasis; Glucocorticoids; Myostatin; Inflammation; Skeletal muscle; Ubiquitin-proteasome

Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the quality of life of cancer patients, decreases the efficiency of therapeutic strategies and ultimately contributes to decrease their lifespan. The depletion of skeletal muscle compartment, which represents the prima...