Major Depressive Disorder Is Associated With Abnormal Interoceptive Activity and Functional Connectivity in the Insula

• Published in: Biological psychiatry (1969) Vol. 76; no. 3; pp. 258 - 266
• Main Authors: Avery, Jason A., Drevets, Wayne C., Moseman, Scott E., Bodurka, Jerzy, Barcalow, Joel C., Simmons, W. Kyle
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Attention - physiology; Biological and medical sciences; Brain - physiopathology; Brain Mapping; Cerebral Cortex - physiopathology; Depression; Depression severity; Depressive Disorder, Major - physiopathology; Female; fMRI; functional connectivity; Humans; insula; interoception; Interoception - physiology; Magnetic Resonance Imaging; major depressive disorder; Male; Medical sciences; Middle Aged; Miscellaneous; Mood disorders; Nerve Net - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Young Adult; fMRI; Depression severity; functional connectivity; interoception; major depressive disorder; insula; Mood disorder; Functional connectivity; Interoception; Central nervous system; Activity; Depression; Nuclear magnetic resonance imaging; Encephalon; Functional magnetic resonance imaging; Medical imagery; Perception; Severity score; Insular cortex; Functional imaging

Somatic complaints and altered interoceptive awareness are common features in the clinical presentation of major depressive disorder (MDD). Recently, neurobiological evidence has accumulated demonstrating that the insula is one of the primary cortical structures underlying interoceptive awareness. A...