Comparative Antioxidant Activities of Curcumin and Its Demethoxy and Hydrogenated Derivatives

• Published in: Biological & Pharmaceutical Bulletin Vol. 30; no. 1; pp. 74 - 78
• Main Authors: Somparn, Poorichaya, Phisalaphong, Chada, Nakornchai, Somjai, Unchern, Supeenun, Morales, Noppawan Phumala
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 2007; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Amidines - chemistry; antioxidant activity; Antioxidants - chemistry; Antioxidants - pharmacology; Biphenyl Compounds; Chromans - pharmacology; curcumin; Curcumin - analogs & derivatives; Curcumin - chemistry; Curcumin - pharmacology; Diarylheptanoids; Erythrocyte Membrane - drug effects; Free Radical Scavengers - pharmacology; Free Radicals - chemistry; Hemolysis - drug effects; hexahydrocurcumin; Humans; Hydrogenation; In Vitro Techniques; Linoleic Acid - chemistry; Lipid Peroxidation - drug effects; Molecular Structure; octahydrocurcumin; Oxidants - chemistry; Picrates - chemistry; Structure-Activity Relationship; tetrahydrocurcumin; Time Factors

The antioxidant activities of curcumin, its natural demethoxy derivatives (demethoxycurcumin, Dmc and bisdemethoxycurcumin, Bdmc) and metabolite hydrogenated derivatives (tetrahydrocurcumin, THC; hexahydrocurcumin, HHC; octahydrocurcumin; OHC) were comparatively studied using 2,2-diphenyl-1-picrylhy...