Integrative Analysis of Transcriptomic and Proteomic Data: Challenges, Solutions and Applications

• Published in: Critical reviews in biotechnology Vol. 27; no. 2; pp. 63 - 75
• Main Authors: Nie, Lei, Wu, Gang, Culley, David E., Scholten, Johannes C. M., Zhang, Weiwen
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.04.2007; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Animals; Data collection; Data Interpretation, Statistical; DNA microarrays; gene expression; genomics; Humans; integration; messenger RNA; monitoring; proteome; proteomics; Proteomics - methods; RNA, Messenger - metabolism; statistical; Transcription, Genetic; transcriptome; transcriptomics

ABSTRACT Recent advances in high-throughput technologies enable quantitative monitoring of the abundance of various biological molecules and allow determination of their variation between biological states on a genomic scale. Two popular platforms are DNA microarrays that measure messenger RNA trans...