Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

• Published in: Lancet neurology Vol. 11; no. 12; pp. 1048 - 1056
• Main Authors: Reiman, Eric M, Quiroz, Yakeel T, Fleisher, Adam S, Chen, Kewei, Velez-Pardo, Carlos, Jimenez-Del-Rio, Marlene, Fagan, Anne M, Shah, Aarti R, Alvarez, Sergio, Arbelaez, Andrés, Giraldo, Margarita, Acosta-Baena, Natalia, Sperling, Reisa A, Dickerson, Brad, Stern, Chantal E, Tirado, Victoria, Munoz, Claudia, Reiman, Rebecca A, Huentelman, Matthew J, Alexander, Gene E, Langbaum, Jessica BS, Kosik, Kenneth S, Tariot, Pierre N, Lopera, Francisco
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2012; Elsevier Limited
• Subjects: Adolescent; Adult; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - blood; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Brain - pathology; Case-Control Studies; Cross-Sectional Studies; Female; Genes, Dominant; Genetic Predisposition to Disease - genetics; Humans; Magnetic Resonance Imaging - methods; Male; Medical imaging; Mutation; Mutation - genetics; Neuroimaging; Neurology; Peptide Fragments - blood; Peptide Fragments - cerebrospinal fluid; Presenilin-1 - blood; Presenilin-1 - cerebrospinal fluid; Presenilin-1 - genetics; Risk Factors; Young Adult; Young adults

We have previously characterised functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's disease. To gain further knowledge on the preclinical phase of Alzheimer's disease, we sought to characterise structural and functional MRI, CSF, and plasma biomarkers...