Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

Common Variation in the Fat Mass and Obesity-Associated ( FTO ) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population Yi-Cheng Chang 1 , Pi-Hua Liu 2 , Wei-Jei Lee 3 , Tien-Jyun Chang 4 , Yi-Der Jiang 4 , Hung-Yuan Li 4 , Shan-Shan Kuo 4 , Kuang-Chin Lee 4 and Lee-Ming Chuang 4 5...

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Published inDiabetes (New York, N.Y.) Vol. 57; no. 8; pp. 2245 - 2252
Main Authors Chang, Yi-Cheng, Liu, Pi-Hua, Lee, Wei-Jei, Chang, Tien-Jyun, Jiang, Yi-Der, Li, Hung-Yuan, Kuo, Shan-Shan, Lee, Kuang-Chin, Chuang, Lee-Ming
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.08.2008
Subjects
Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Asian People - genetics
Biological and medical sciences
Body Mass Index
China
Cytoskeletal Proteins
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Gastrointestinal surgery
Gene Frequency
Genes
Genetic aspects
Genetic Predisposition to Disease
Genetics
Genomes
Genotype
Genotype & phenotype
Glucose
Health aspects
Homeostasis
Hospitals
Humans
Insulin resistance
Male
Medical sciences
Medical screening
Metabolic diseases
Metabolism
Middle Aged
Obesity
Obesity - ethnology
Obesity - genetics
Obesity - physiopathology
Plasma
Polymorphism, Single Nucleotide
Proteins - genetics
Proteins - physiology
Research design
Risk Factors
Single nucleotide polymorphisms
Software
Type 2 diabetes
China
Japan
Taiwan
Endocrinopathy
Obesity
Gene
Diabetes mellitus
Nutrition disorder
Risk factor
Chinese
Fat mass
Nutritional status
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Abstract Common Variation in the Fat Mass and Obesity-Associated ( FTO ) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population Yi-Cheng Chang 1 , Pi-Hua Liu 2 , Wei-Jei Lee 3 , Tien-Jyun Chang 4 , Yi-Der Jiang 4 , Hung-Yuan Li 4 , Shan-Shan Kuo 4 , Kuang-Chin Lee 4 and Lee-Ming Chuang 4 5 1 Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan 2 Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 3 Department of Surgery, Ming-Sheng General Hospital, Taoyuan, Taiwan 4 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan 5 Graduate Institute of Clinical Medicine, National Taiwan University Medical College, Taipei, Taiwan Corresponding author: Lee-Ming Chuang, leeming{at}ntu.edu.tw Abstract OBJECTIVE— Genetic variants in the fat mass and obesity-associated ( FTO ) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. RESEARCH DESIGN AND METHODS— We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3′ end of the neighboring RPGRIP1L gene to the 5′ flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. RESULTS— Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity ( P = 7.0 × 10 −4 ) and BMI ( P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24–5.46) ( P = 0.011) for the AA genotype and 1.32 (1.05–1.66) ( P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of ∼0.37 kg/m 2 . The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. CONCLUSIONS— Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population. Footnotes Published ahead of print at http://diabetes.diabetesjournals.org on 13 May 2008. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Accepted May 8, 2008. Received March 17, 2008. DIABETES
AbstractList OBJECTIVE— Genetic variants in the fat mass and obesity-associated ( FTO ) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. RESEARCH DESIGN AND METHODS— We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3′ end of the neighboring RPGRIP1L gene to the 5′ flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. RESULTS— Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity ( P = 7.0 × 10 −4 ) and BMI ( P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24–5.46) ( P = 0.011) for the AA genotype and 1.32 (1.05–1.66) ( P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of ∼0.37 kg/m 2 . The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. CONCLUSIONS— Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.
Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3' end of the neighboring RPGRIP1L gene to the 5' flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 x 10(-4)) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24-5.46) (P = 0.011) for the AA genotype and 1.32 (1.05-1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of approximately 0.37 kg/m(2). The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.
Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population.OBJECTIVEGenetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population.We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3' end of the neighboring RPGRIP1L gene to the 5' flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects.RESEARCH DESIGN AND METHODSWe genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3' end of the neighboring RPGRIP1L gene to the 5' flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects.Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 x 10(-4)) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24-5.46) (P = 0.011) for the AA genotype and 1.32 (1.05-1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of approximately 0.37 kg/m(2). The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits.RESULTSAmong the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 x 10(-4)) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24-5.46) (P = 0.011) for the AA genotype and 1.32 (1.05-1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of approximately 0.37 kg/m(2). The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits.Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.CONCLUSIONSGenetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.
Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3' end of the neighboring RPGRIP1L gene to the 5' flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 x 10(-4)) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24-5.46) (P = 0.011) for the AA genotype and 1.32 (1.05-1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of approximately 0.37 kg/m(2). The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.
OBJECTIVE— Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. RESEARCH DESIGN AND METHODS— We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3′ end of the neighboring RPGRIP1L gene to the 5′ flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. RESULTS— Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity (P = 7.0 × 10−4) and BMI (P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24–5.46) (P = 0.011) for the AA genotype and 1.32 (1.05–1.66) (P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of ∼0.37 kg/m2. The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. CONCLUSIONS— Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population.
Common Variation in the Fat Mass and Obesity-Associated ( FTO ) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population Yi-Cheng Chang 1 , Pi-Hua Liu 2 , Wei-Jei Lee 3 , Tien-Jyun Chang 4 , Yi-Der Jiang 4 , Hung-Yuan Li 4 , Shan-Shan Kuo 4 , Kuang-Chin Lee 4 and Lee-Ming Chuang 4 5 1 Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan 2 Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan 3 Department of Surgery, Ming-Sheng General Hospital, Taoyuan, Taiwan 4 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan 5 Graduate Institute of Clinical Medicine, National Taiwan University Medical College, Taipei, Taiwan Corresponding author: Lee-Ming Chuang, leeming{at}ntu.edu.tw Abstract OBJECTIVE— Genetic variants in the fat mass and obesity-associated ( FTO ) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test the role of FTO genetic variants in obesity and type 2 diabetes in the Chinese population. RESEARCH DESIGN AND METHODS— We genotyped 19 single-nucleotide polymorphisms (SNPs) spanning from the 3′ end of the neighboring RPGRIP1L gene to the 5′ flanking region of the FTO gene. We analyzed their associations with obesity (638 case and 1,610 control subjects), type 2 diabetes (759 case and 784 control subjects), and obesity-related traits in nondiabetic subjects. RESULTS— Among the 19 SNPs, the rs9939609 A allele was strongly associated with obesity ( P = 7.0 × 10 −4 ) and BMI ( P = 0.0024) in the Chinese population. The odds ratio for obesity was 2.60 (95% CI 1.24–5.46) ( P = 0.011) for the AA genotype and 1.32 (1.05–1.66) ( P = 0.018) for the AT genotype compared with the TT genotype. Each additional copy of the rs9936609 A allele was associated with a BMI increase of ∼0.37 kg/m 2 . The rs9939609 A allele was substantially less common in the Chinese population than in the European population (12.6 vs. 45%). We did not find significant associations of the 19 SNPs with type 2 diabetes or other obesity-related traits. CONCLUSIONS— Genetic variation in the FTO gene is strongly associated with obesity and BMI in the Chinese population. The risk variant is less common in the Chinese population, but its effect size on BMI is comparable with that in the European population. Footnotes Published ahead of print at http://diabetes.diabetesjournals.org on 13 May 2008. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Accepted May 8, 2008. Received March 17, 2008. DIABETES
Audience Professional
Author Pi-Hua Liu
Lee-Ming Chuang
Yi-Cheng Chang
Shan-Shan Kuo
Kuang-Chin Lee
Tien-Jyun Chang
Yi-Der Jiang
Wei-Jei Lee
Hung-Yuan Li
AuthorAffiliation 2 Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
5 Graduate Institute of Clinical Medicine, National Taiwan University Medical College, Taipei, Taiwan
3 Department of Surgery, Ming-Sheng General Hospital, Taoyuan, Taiwan
1 Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
4 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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  organization: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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  organization: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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  givenname: Hung-Yuan
  surname: Li
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  organization: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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  surname: Kuo
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  organization: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
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Issue 8
Keywords Endocrinopathy
Obesity
Gene
Diabetes mellitus
Nutrition disorder
Risk factor
Chinese
Fat mass
Nutritional status
Language English
License CC BY 4.0
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
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content type line 14
content type line 23
Published ahead of print at http://diabetes.diabetesjournals.org on 13 May 2008.
Corresponding author: Lee-Ming Chuang, leeming@ntu.edu.tw
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC2494679
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PublicationTitle Diabetes (New York, N.Y.)
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Snippet Common Variation in the Fat Mass and Obesity-Associated ( FTO ) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population Yi-Cheng Chang 1 ,...
OBJECTIVE— Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We...
Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations. We aimed to test...
OBJECTIVE— Genetic variants in the fat mass and obesity-associated ( FTO ) gene have been linked with obesity and type 2 diabetes in European populations. We...
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SubjectTerms Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Asian People - genetics
Biological and medical sciences
Body Mass Index
China
Cytoskeletal Proteins
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Gastrointestinal surgery
Gene Frequency
Genes
Genetic aspects
Genetic Predisposition to Disease
Genetics
Genomes
Genotype
Genotype & phenotype
Glucose
Health aspects
Homeostasis
Hospitals
Humans
Insulin resistance
Male
Medical sciences
Medical screening
Metabolic diseases
Metabolism
Middle Aged
Obesity
Obesity - ethnology
Obesity - genetics
Obesity - physiopathology
Plasma
Polymorphism, Single Nucleotide
Proteins - genetics
Proteins - physiology
Research design
Risk Factors
Single nucleotide polymorphisms
Software
Type 2 diabetes
Title Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population
URI http://diabetes.diabetesjournals.org/content/57/8/2245.abstract
https://www.ncbi.nlm.nih.gov/pubmed/18487448
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Volume 57
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