Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

• Published in: Diabetes (New York, N.Y.) Vol. 56; no. 5; pp. 1376 - 1381
• Main Authors: Befroy, Douglas E., Petersen, Kitt Falk, Dufour, Sylvie, Mason, Graeme F., de Graaf, Robin A., Rothman, Douglas L., Shulman, Gerald I.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2007
• Subjects: Adult; Biological and medical sciences; Body Mass Index; Carbon Isotopes; Chemical properties; Citric Acid Cycle; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty acids; Female; Glucose Tolerance Test; Health aspects; Humans; Hypotheses; Insulin resistance; Insulin Resistance - physiology; Kinases; Kinetics; Life Style; Lipids; Magnetic Resonance Spectroscopy; Male; Medical sciences; Metabolism; Metabolites; Mitochondria, Muscle - metabolism; Models, Biological; Musculoskeletal system; Nuclear Family; Oxidation; Oxidation-Reduction; Oxidation-reduction reaction; Oxidation-reduction reactions; Pathogenesis; Phosphorylation; Physiological aspects; Spectrum analysis; Type 2 diabetes; United States; Endocrinopathy; Type 2 diabetes; Human; Pancreatic hormone; Mitochondria; Metabolic diseases; Muscle; Oxidation; Insulin

Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients Douglas E. Befroy 1 , Kitt Falk Petersen 1 , Sylvie Dufour 2 , Graeme F. Mason 3 , Robin A. de Graaf 3 , Douglas L. Rothman 3 and Gerald I. Shulman 1 2 4 1 Department of Internal Medicine,...