Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/ cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1 - Cui, Kai; Luan, Yang; Wang, Tao; Zhuan, Li; Rao, Ke; Wang, Shao-Gang; Ye, Zhang-Qun; Liu, Ji-Hong; Wang, Dao-Wen (Asian journal of andrology, 2017)
Keywords: Actin Depolymerizing Factors - metabolism; Age; aged; corporal fibrosis; erectile dysfunction; gene therapy; hKLK1; Aging - metabolism; Aging - pathology; Animals; Animals, Genetically Modified; Blotting, Western; Collagen - metabolism; Deoxyribonucleic acid; DNA; Erectile Dysfunction - metabolism; Erectile Dysfunction - pathology; Experiments; Fibrosis; Health aspects; Immunohistochemistry; Impotence; Kinases; Laboratory animals; Lim Kinases - metabolism; Male; Medical research; Myocytes, Smooth Muscle - pathology; Original; Penis - pathology; Phosphoproteins; Phosphotransferases; Prevention; Protein Phosphatase 1 - metabolism; Proteins; Rats; Rats, Sprague-Dawley; rho-Associated Kinases - metabolism; rhoA GTP-Binding Protein - metabolism; Rodents; Signal Transduction; Smooth muscle; Studies; Tissue Kallikreins - genetics; Transforming Growth Factor beta1 - metabolism