transcription factor ATF5: role in neurodevelopment and neural tumors

• Published in: Journal of neurochemistry Vol. 108; no. 1; pp. 11 - 22
• Main Authors: Greene, Lloyd A, Lee, Hae Young, Angelastro, James M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.01.2009; Blackwell Publishing Ltd; Wiley-Blackwell
• Subjects: Activating Transcription Factors; Activating Transcription Factors - genetics; Activating Transcription Factors - metabolism; Animals; ATF5; Biochemistry; Biological and medical sciences; Cell Differentiation; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cellular biology; development; Developmental biology; drug effects; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Neoplastic - physiology; genetics; Glioblastoma; Glioblastoma - genetics; Glioblastoma - metabolism; Glioblastoma - pathology; glioma; growth & development; Humans; Medical sciences; metabolism; Molecular and cellular biology; Molecular genetics; Nervous System; Nervous System - growth & development; Nervous System - metabolism; Nervous System Neoplasms; Nervous System Neoplasms - genetics; Nervous System Neoplasms - metabolism; Nervous System Neoplasms - pathology; neural progenitor; Neurology; neurotrophic factors; neurotrophins; pathology; physiology; transcription factor; Transcription. Transcription factor. Splicing. Rna processing; Tumors; Tumors of the nervous system. Phacomatoses; Cell proliferation; Neuroglia; Nervous system; Review; Leucine; Malignant glioma; Basic protein; Development; Transcription factor; Nervous system diseases; neural progenitor; Malignant tumor; Cell differentiation; In vitro; Survival; Cerebral disorder; Neuron; Medulloblastoma; neurotrophic factors; Central nervous system disease; glioma; Autonomic neuropathy; Differentiation; ATF5; Cancer

We review recent findings regarding the properties of ATF5 and the major roles that this transcription factor plays in development of the nervous system and in survival of neural tumors. ATF5 is a widely expressed basic leucine zipper protein that has been subject to limited characterization. It is...