Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors

• Published in: Chemical & pharmaceutical bulletin Vol. 68; no. 12; pp. 1184 - 1192
• Main Authors: Peng, Zhiyun, Li, Yongjun, Liu, Wenjing, Wang, Guangcheng
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 01.12.2020; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Amines; anticancer; Anticancer properties; Apoptosis; Biotechnology; Cell cycle; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Cisplatin; Colchicine; Life Sciences & Biomedicine; Molecular modelling; naphthalene; Pharmacology & Pharmacy; Physical Sciences; Polymerization; pyrimidine; Science & Technology; Tubulin; tubulin polymerization inhibitor; Tumor cell lines; POTENTIAL ANTICANCER AGENTS; PYRIMIDINE-DERIVATIVES; naphthalene; MECHANISMS; IDENTIFICATION; pyrimidine; tubulin polymerization inhibitor; BINDING; anticancer
• ISSN: 0009-2363; 1347-5223; 1347-5223
• DOI: 10.1248/cpb.c20-00575

A novel series of 4-(4-methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines were designed, synthesized, and evaluated for their anticancer activities. Most of the synthesized compounds exhibited moderate to high antiproliferative activity in comparison to the standard drug cisplatin. Among them, 5i bear...